Search results for "Computer Science Application"
showing 10 items of 3998 documents
MCR-ALS on metabolic networks: Obtaining more meaningful pathways
2015
[EN] With the aim of understanding the flux distributions across a metabolic network, i.e. within living cells, Principal Component Analysis (PCA) has been proposed to obtain a set of orthogonal components (pathways) capturing most of the variance in the flux data. The problems with this method are (i) that no additional information can be included in the model, and (ii) that orthogonality imposes a hard constraint, not always reasonably. To overcome these drawbacks, here we propose to use a more flexible approach such as Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) to obtain this set of biological pathways through the network. By using this method, different constraint…
Bayesian prediction inM/M/1 queues
1994
Simple queues with Poisson input and exponential service times are considered to illustrate how well-suited Bayesian methods are used to handle the common inferential aims that appear when dealing with queue problems. The emphasis will mainly be placed on prediction; in particular, we study the predictive distribution of usual measures of effectiveness in anM/M/1 queue system, such as the number of customers in the queue and in the system, the waiting time in the queue and in the system, the length of an idle period and the length of a busy period.
Scatter Search and Path Relinking
2011
Scatter search (SS) and path relinking (PR) are evolutionary methods that have been successfully applied to a wide range of hard optimization problems. The fundamental concepts and principles of the methods were first proposed in the 1970s and 1980s, and were based on formulations, dating back to the 1960s, for combining decision rules and problem constraints. The methods use strategies for search diversification and intensification that have proved effective in a variety of optimization problems and that have sometimes been embedded in other evolutionary methods to yield improved performance. This paper examines the scatter search and path relinking methodologies from both conceptual and p…
Adjoint-based sampling methods for electromagnetic scattering
2010
In this paper we investigate the efficient realization of sampling methods based on solutions of certain adjoint problems. This adjoint approach does not require the explicit knowledge of the Green's function for the background medium, and allows us to sample for all points and all dipole directions simultaneously; thus, several limitations of standard sampling methods are relieved. A detailed derivation of the adjoint approach is presented for two electromagnetic model problems, but the framework can be applied to a much wider class of problems. We also discuss a relation of the adjoint sampling method to standard backprojection algorithms, and present numerical tests that illustrate the e…
Sufficient conditions for coincidence in minisum multifacility location problems with a general metric
1991
It is a well observed fact that in minisum multifacility location problems the optimal locations of several facilities often tend to coincide. Some sufficient conditions for this phenomenon, involving only the weights and applicable to any metric, have been published previously. The objective of this paper is to show how these conditions may be extended further and to obtain a more complete description of their implications, in particular, in the case of certain locational constraints.
Estimation of the elastic parameters of human liver biomechanical models by means of medical images and evolutionary computation.
2013
This paper presents a method to computationally estimate the elastic parameters of two biomechanical models proposed for the human liver. The method is aimed at avoiding the invasive measurement of its mechanical response. The chosen models are a second order Mooney–Rivlin model and an Ogden model. A novel error function, the geometric similarity function (GSF), is formulated using similarity coefficients widely applied in the field of medical imaging (Jaccard coefficient and Hausdorff coefficient). This function is used to compare two 3D images. One of them corresponds to a reference deformation carried out over a finite element (FE) mesh of a human liver from a computer tomography image, …
On Optimal Solutions for the Optimal Communication Spanning Tree Problem
2009
This paper presents an experimental investigation into the properties of the optimal communication spanning tree (OCST) problem. The OCST problem seeks a spanning tree that connects all the nodes and satisfies their communication requirements at a minimum total cost. The paper compares the properties of random trees to the properties of the best solutions for the OCST problem that are found using an evolutionary algorithm. The results show, on average, that the optimal solution and the minimum spanning tree (MST) share a higher number of links than the optimal solution and a random tree. Furthermore, optimal solutions for OCST problems with randomly chosen distance weights share a higher n…
Optimal Impulse Control When Control Actions Have Random Consequences
1997
We consider a generalised impulse control model for controlling a process governed by a stochastic differential equation. The controller can only choose a parameter of the probability distribution of the consequence of his control action which is therefore random. We state optimality results relating the value function to quasi-variational inequalities and a formal optimal stopping problem. We also remark that the value function is a viscosity solution of the quasi-variational inequalities which could lead to developments and convergence proofs of numerical schemes. Further, we give some explicit examples and an application in financial mathematics, the optimal control of the exchange rate…
A novel technique for stochastic root-finding: Enhancing the search with adaptive d-ary search
2017
The most fundamental problem encountered in the field of stochastic optimization, is the Stochastic Root Finding (SRF) problem where the task is to locate an unknown point x∗ for which g(x∗) = 0 for a given function g that can only be observed in the presence of noise [15]. The vast majority of the state-of-the-art solutions to the SRF problem involve the theory of stochastic approximation. The premise of the latter family of algorithms is to oper ate by means of so-called “small-step”processesthat explorethe search space in a conservative manner. Using this paradigm, the point investigated at any time instant is in the proximity of the point investigated at the previous time instant, render…
Optimal Paths on Urban Networks Using Travelling Times Prevision
2012
We deal with an algorithm that, once origin and destination are fixed, individuates the route that permits to reach the destination in the shortest time, respecting an assigned maximal travel time, and with risks measure below a given threshold. A fluid dynamic model for road networks, according to initial car densities on roads and traffic coefficients at junctions, forecasts the future traffic evolution, giving dynamical weights to a constrained 𝐾 shortest path algorithm. Simulations are performed on a case study to test the efficiency of the proposed procedure.