Search results for "Computer Science Application"
showing 10 items of 3998 documents
In Vitro Phytotoxicity and Antioxidant Activity of Selected Flavonoids
2012
Made available in DSpace on 2013-09-27T14:54:27Z (GMT). No. of bitstreams: 1 WOS000306186200008.pdf: 228949 bytes, checksum: 818c9c7c18b61f5827cc5873d4eed670 (MD5) Previous issue date: 2012-05-01 Made available in DSpace on 2013-09-30T18:36:37Z (GMT). No. of bitstreams: 1 WOS000306186200008.pdf: 228949 bytes, checksum: 818c9c7c18b61f5827cc5873d4eed670 (MD5) Previous issue date: 2012-05-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:48:50Z No. of bitstreams: 1 WOS000306186200008.pdf: 228949 bytes, checksum: 818c9c7c18b61f5827cc5873d4eed670 (MD5) Made available in DSpace on 2014-05-20T13:48:50Z (GMT). No. of bitstreams: 1 WOS000306186200008.pdf: …
Theoretical Determination of the pK a Values of Betalamic Acid Related to the Free Radical Scavenger Capacity: Comparison Between Empirical and Quant…
2015
Health benefits of dietary phytochemicals have been suggested in recent years. Among 1000s of different compounds, Betalains, which occur in vegetables of the Cariophyllalae order (cactus pear fruits and red beet), have been considered because of reducing power and potential to affect redox-modulated cellular processes. The antioxidant power of Betalains is strictly due to the dissociation rate of the acid moieties present in all the molecules of this family of phytochemicals. Experimentally, only the pK a values of betanin were determined. Recently, it was evidenced it was evidenced as the acid dissociation, at different environmental pHs, affects on its electron-donating capacity, and fur…
Xenopus Oocyte’s Conductance for Bioactive Compounds Screening and Characterization
2019
Background: Astaxanthin (ATX) is a lipophilic compound found in many marine organisms. Studies have shown that ATX has many strong biological properties, including antioxidant, antiviral, anticancer, cardiovascular, anti-inflammatory, neuro-protective and anti-diabetic activities. However, no research has elucidated the effect of ATX on ionic channels. ATX can be extracted from shrimp by-products. Our work aims to characterize ATX cell targets to lend value to marine by-products. Methods: We used the Xenopus oocytes cell model to characterize the pharmacological target of ATX among endogenous Xenopus oocytes&rsquo
Antioxidant Properties of a Supercritical Fluid Extract of the Halophyte Mesembryanthemum nodiflorum L. from Sicilian Coasts: Nutraceutical and Cosme…
2020
The aim of this paper was to obtain different extracts from the aerial parts of Mesembryanthemum nodiflorum, comparing traditional extraction (using solvents with increasing polarity such as hexane, ethanol 80%, acetone 70% and water) with an eco-friendly technique (supercritical fluid extraction (SFE))
Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease.
2015
Cardiovascular disease is a leading cause of death and reduced quality of life worldwide. Arterial vessels are a primary target for endothelial dysfunction and atherosclerosis, which is accompanied or even driven by increased oxidative stress. Recent research in this field identified different sources of reactive oxygen and nitrogen species contributing to the pathogenesis of endothelial dysfunction. According to lessons from the past, improvement of endothelial function and prevention of cardiovascular disease by systemic, unspecific, oral antioxidant therapy are obviously too simplistic an approach. Source- and cell organelle-specific antioxidants as well as activators of intrinsic antiox…
Screening of antioxidant potentials and bioactive properties of the extracts obtained from two Centaurea L. species (C. kroumirensis coss. and C. sic…
2020
Herbal medicines, dietary supplements, or infusions with health promoting effects can note strong consumer demand. Hence, researchers and scientists have been increasingly focusing on the promotion of medicinal plants. In this respect, the present study has the evaluation of the biological properties of different extracts (hexane, chloroform, methanol, ultrasonic, essential oil, and supercritical) obtained from two Centaurea species (C. kroumirensis (Coss.) and C. sicula L. subsp sicula) as purpose. Antioxidative activities were assessed by in vitro assays including total phenolic content, free radical scavenging assay and ferric ion reducing power. Among the fourteen extracts examined, the…
Comparison of hemodynamic and structural indices of ascending thoracic aortic aneurysm as predicted by 2-way FSI, CFD rigid wall simulation and patie…
2018
Patient-specific computational modeling is increasingly being used to predict structural and hemodynamic parameters, especially when current clinical tools are not accessible. Indeed, pathophysiology of ascending thoracic aortic aneurysm (ATAA) has been simulated to quantify the risk of complications by novel prognostic parameters and thus to improve the clinical decision-making process related to the intervention of ATAAs. In this study, the relevance of aneurysmal wall elasticity in determining parameters of clinical importance, such as the wall shear stress (WSS), is discussed together with the significance of applying realistic boundary conditions to consider the aortic stretch and twis…
Binary Hamming codes and Boolean designs
2021
AbstractIn this paper we consider a finite-dimensional vector space $${\mathcal {P}}$$ P over the Galois field $${\text {GF}}(2),$$ GF ( 2 ) , and the family $${\mathcal {B}}_k$$ B k (respectively, $${\mathcal {B}}_k^*$$ B k ∗ ) of all the k-sets of elements of $$\mathcal {P}$$ P (respectively, of $${\mathcal {P}}^*= {\mathcal {P}} \setminus \{0\}$$ P ∗ = P \ { 0 } ) summing up to zero. We compute the parameters of the 3-design $$({\mathcal {P}},{\mathcal {B}}_k)$$ ( P , B k ) for any (necessarily even) k, and of the 2-design $$({\mathcal {P}}^{*},{\mathcal {B}}_k^{*})$$ ( P ∗ , B k ∗ ) for any k. Also, we find a new proof for the weight distribution of the binary Hamming code. Moreover, we…
Identification of multiplicatively acting modulatory mutational signatures in cancer
2022
Abstract Background A deep understanding of carcinogenesis at the DNA level underpins many advances in cancer prevention and treatment. Mutational signatures provide a breakthrough conceptualisation, as well as an analysis framework, that can be used to build such understanding. They capture somatic mutation patterns and at best identify their causes. Most studies in this context have focused on an inherently additive analysis, e.g. by non-negative matrix factorization, where the mutations within a cancer sample are explained by a linear combination of independent mutational signatures. However, other recent studies show that the mutational signatures exhibit non-additive interactions. Resu…