Search results for "Computer Science Applications"
showing 10 items of 3993 documents
The Effect of tRNA
2021
Transfer RNA[Ser]Sec carries multiple post-transcriptional modifications. The A37G mutation in tRNA[Ser]Sec abrogates isopentenylation of base 37 and has a profound effect on selenoprotein expression in mice. Patients with a homozygous pathogenic p.R323Q variant in tRNA-isopentenyl-transferase (TRIT1) show a severe neurological disorder, and hence we wondered whether selenoprotein expression was impaired. Patient fibroblasts with the homozygous p.R323Q variant did not show a general decrease in selenoprotein expression. However, recombinant human TRIT1R323Q had significantly diminished activities towards several tRNA substrates in vitro. We thus engineered mice conditionally deficient in Tr…
Test of the electric charge conservation law with Borexino detector
2015
International audience; The new limit on the electron lifetime is obtained from data of the Borexino experiment. The expected signal from the e → γν decay mode is a 256 keV photon detected in liquid scintillator. Because of the extremely low radioactive background level in the Borexino detector it was possible to improve the previous measurement by two orders of magnitude.
Clustering techniques for personal photo album management
2009
In this work we propose a novel approach for the automatic representation of pictures achieving at more effective organization of personal photo albums. Images are analyzed and described in multiple representation spaces, namely, faces, background and time of capture. Faces are automatically detected, rectified and represented projecting the face itself in a common low-dimensional eigenspace. Backgrounds are represented with low-level visual features based on RGB histogram and Gabor filter bank. Faces, time and background information of each image in the collection is automatically organized using a mean-shift clustering technique. Given the particular domain of personal photo libraries, wh…
Subjective Experience and Sociability in a Collaborative Serious Game
2013
The meaning of social dimension of gaming for enjoyable and engaging game experiences is supported by an increasing amount of research. Nonetheless, this issue has rarely been studied in the context of serious games. This study attempts to narrow the knowledge gap in the understanding of collaborative serious game experiences and the relationship between the social dimension of gaming and core game experiences. The aim of this study is to empirically investigate what kinds of game experiences are generated when playing collaborative serious game and how the sense of social presence and the sociability of the environment are connected to the core game experience. Findings reinforce the idea…
Game Mechanics in the Design of a Collaborative 3D Serious Game
2014
Background. This article investigates the potential of utilizing game mechanics in designing 3-D serious games for Computer-Supported Collaborative Learning (CSCL) and attempt to produce new information about designing collaborative serious games. Aim. This article has two aims: first, to clarify how theoretical knowledge of collaborative learning was related to game design in previous studies; and, second, to design a collaborative serious game based on theoretical knowledge of collaborative learning and game design. Results. The reviewed studies revealed the potential of using collaborative games in education. However, they showed that collaborative learning games were typically designed …
La perspectiva de género y el papel de la universidad en el siglo XXI
2015
El artículo presenta la línea de docencia e investigación emergentes que están desarrollando las autoras. Se parte de las necesidades percibidas por el estudiantado de dos universidades: la Universidad de Valencia y de la Universidad Autónoma del Estado de Morelos; y recogidas a través de un cuestionario (diseñado ad hoc y validado) y de varios grupos de discusión. La actuación del profesorado se considera elemento catalizador en la construcción de nuevas identidades profesionales y éticas capaces de responder a los retos del siglo XXI. Se exploran y señalan algunos retos para hacer posible el desarrollo de la docencia, la investigación y la gestión libres de sesgos de género. Se concluye r…
Argumentation in Secondary School Students' Structured and Unstructured Chat Discussions
2012
Joint construction of new knowledge demands that persons can express their statements in a convincing way and explore other people's arguments constructively. For this reason, more knowledge on different means to support collaborative argumentation is needed. This study clarifies whether structured interaction supports students' critical and elaborative argumentation. The study compares the quality of secondary school students' argumentation during structured and unstructured chat interaction. The data consist of 16 dyadic chat discussions: 8 discussions concerned vivisection and 8 gender equality. Half of the discussions were carried out through structured chat, and the other half through…
Dynamics of gene regulatory networks and their dependence on network topology and quantitative parameters – the case of phage λ
2019
Background Gene regulatory networks can be modelled in various ways depending on the level of detail required and biological questions addressed. One of the earliest formalisms used for modeling is a Boolean network, although these models cannot describe most temporal aspects of a biological system. Differential equation models have also been used to model gene regulatory networks, but these frameworks tend to be too detailed for large models and many quantitative parameters might not be deducible in practice. Hybrid models bridge the gap between these two model classes – these are useful when concentration changes are important while the information about precise concentrations and binding…
The “Janus” Role of C/EBPs Family Members in Cancer Progression
2020
CCAAT/enhancer-binding proteins (C/EBPs) constitute a family of transcription factors composed of six members that are critical for normal cellular differentiation in a variety of tissues. They promote the expression of genes through interaction with their promoters. Moreover, they have a key role in regulating cellular proliferation through interaction with cell cycle proteins. C/EBPs are considered to be tumor suppressor factors due to their ability to arrest cell growth (contributing to the terminal differentiation of several cell types) and for their role in cellular response to DNA damage, nutrient deprivation, hypoxia, and genotoxic agents. However, C/EBPs can elicit completely opposi…
Disparity between Inter-Patient Molecular Heterogeneity and Repertoires of Target Drugs Used for Different Types of Cancer in Clinical Oncology
2020
Inter-patient molecular heterogeneity is the major declared driver of an expanding variety of anticancer drugs and personalizing their prescriptions. Here, we compared interpatient molecular heterogeneities of tumors and repertoires of drugs or their molecular targets currently in use in clinical oncology. We estimated molecular heterogeneity using genomic (whole exome sequencing) and transcriptomic (RNA sequencing) data for 4890 tumors taken from The Cancer Genome Atlas database. For thirteen major cancer types, we compared heterogeneities at the levels of mutations and gene expression with the repertoires of targeted therapeutics and their molecular targets accepted by the current guideli…