Search results for "Computer aided"
showing 10 items of 93 documents
Automated classification of focal breast lesions according to S-detect: validation and role as a clinical and teaching tool
2018
Abstract PURPOSE: To assess the diagnostic performance and the potential as a teaching tool of S-detect in the assessment of focal breast lesions. METHODS: 61 patients (age 21-84 years) with benign breast lesions in follow-up or candidate to pathological sampling or with suspicious lesions candidate to biopsy were enrolled. The study was based on a prospective and on a retrospective phase. In the prospective phase, after completion of baseline US by an experienced breast radiologist and S-detect assessment, 5 operators with different experience and dedication to breast radiology performed elastographic exams. In the retrospective phase, the 5 operators performed a retrospective assessment a…
A Fuzzy-based Clinical Decision Support System for coeliac disease
2022
Coeliac disease (CD) is a permanent inflammatory disease of the small intestine characterized by the destruction of the mucous membrane of this intestinal tract. Coeliac disease represents the most frequent food intolerance and affects about 1% of the population, but it is severely underdiagnosed. Currently available guidelines require CD-specific serology and atrophic histology in duodenal biopsy samples to diagnose CD in adults. In paediatric CD, but recently in adults also, non-invasive diagnostic strategies have become increasingly popular. In order to increase the rates of correct diagnosis of the disease without the use of biopsy, researchers have recently been using approaches based …
Introduction to molecular topology: basic concepts and application to drug design.
2012
In this review it is dealt the use of molecular topology (MT) in the selection and design of new drugs. After an introduction of the actual methods used for drug design, the basic concepts of MT are defined, including examples of calculation of topological indices, which are numerical descriptors of molecular structures. The goal is making this calculation familiar to the potential students and allowing a straightforward comprehension of the topic. Finally, the achievements obtained in this field are detailed, so that the reader can figure out the great interest of this approach.
The CALMA system: an artificial neural network method for detecting masses and microcalcifications in digitized mammograms
2004
The CALMA (Computer Assisted Library for MAmmography) project is a five years plan developed in a physics research frame in collaboration between INFN (Istituto Nazionale di Fisica Nucleare) and many Italian hospitals. At present a large database of digitized mammographic images (more than 6000) was collected and a software based on neural network algorithms for the search of suspicious breast lesions was developed. Two tools are available: a microcalcification clusters hunter, based on supervised and unsupervised feedforward neural network, and a massive lesions searcher, based on a hibrid approach. Both the algorithms analyzed preprocessed digitized images by high frequency filters. Clini…
Negotiation mechanisms for capacity allocation in distributed enterprises
2003
Abstract The paper proposes an agent based approach for the capacity allocation in distributed enterprises, characterized by complex and articulated organizations and by geographically distributed production capacities contended by many product families. In such a scenario the process of allocating the production capacity to the single customer order is one the major bottlenecks of the production planning activity as far as many organizational decisional levels are involved and market turbulence implies a continuous retuning of the capacity allocation plan. A high grade of reactiveness is needed. Agent based approaches and negotiation models, by decentralizing the decisional control and sim…
Aims vs. technology: Pedagogical view to the use of educational applications in safety critical contexts
2011
Interactive technology for education has formed into a relatively independent domain of research and development. Interactive technology is often seen as a context independent tool. However, we argue that education in different contexts may have so different and incommensurable aims that no single technology can be announced as good or bad per se in terms of learning. The development of educational application should not be based on the technology to be applied, but by careful analysis of learning aims. When formulated in an appropriate way, learning aims work as a relevant basis in all stages of the design process of an educational application. The formulation of aims is therefore critical…
Introducing a novel mesh following technique for approximation-free robotic tool path trajectories
2017
Abstract Modern tools for designing and manufacturing of large components with complex geometries allow more flexible production with reduced cycle times. This is achieved through a combination of traditional subtractive approaches and new additive manufacturing processes. The problem of generating optimum tool-paths to perform specific actions (e.g. part manufacturing or inspection) on curved surface samples, through numerical control machinery or robotic manipulators, will be increasingly encountered. Part variability often precludes using original design CAD data directly for toolpath generation (especially for composite materials), instead surface mapping software is often used to gener…
Optimization of fluorescence enhancement for silicon-based microarrays
2008
An optical technique for the enhancement of fluorescence detection sensitivity on planar samples is presented. Such a technique is based on the simultaneous optimization of excitation and light collection by properly combining interference and reflectance from the sample holder. Comparative tests have been performed in microarray applications, by evaluating the proposed solution against commercial glass-based devices, using popular labeling dyes, such as Cy3 and Cy5. The proposed technique is implemented on a substrate built with standard silicon technology and is therefore well suited for integrated micro total analysis systems (microTAS) applications.
Highly stable Zerodur based optical benches for microgravity applications and other adverse environments
2019
A number of cold atom experiments are restrained by the impeding effects of gravity. While efforts have been made to overcome these limitations in a gravitational environment, another approach is placing the experiment in a microgravity environment, as can be found aboard sounding rockets, satellites or a space station. The cornerstone of such experiments is a robust laser system. The adverse conditions during a rocket launch impose stringent requirements on thermal stability and resilience against mechanical stress on this part of the experimental setup. Furthermore, the very limited space found on any of the aforementioned microgravity platforms necessitates maximal miniaturization. In or…
CAD of complex passive devices composed of arbitrarily shaped waveguides using Nyström and BI-RME methods
2004
In this paper, a novel computer-aided design (CAD) tool of complex passive microwave devices in waveguide technology is proposed. Such a tool is based on a very efficient integral-equation analysis technique that provides a full-wave characterization of discontinuities between arbitrarily shaped waveguides defined by linear, circular, and/or elliptical arcs. For solving the modal analysis of such arbitrary waveguides, a modified version of the well-known boundary integral-resonant-mode expansion (BI-RME) method using the Nyström approach, instead of the traditional Galerkin version of the method of moments, is proposed, thus providing significant savings on computational costs and implement…