Search results for "Computer simulation"
showing 10 items of 1054 documents
Gradient-based shape optimisation of ultra-wideband antennas parameterised using splines
2010
Methodology enabling the gradient-based optimisation of antennas parameterised using B-splines is presented. Use of the spline parametrisation allows us to obtain versatile new shapes, whereas the geometry can be represented with a small set of design variables. Moreover, good control over admissible geometries is retained. Advantages of gradient-based optimisation methods are quick convergence, and the fact that the obtained design can be guaranteed to be a local optimum. Focus of this study is to present techniques that enable the computation of exact gradients of the discrete problem, even though the complexity of the geometries does not permit establishing analytical expressions for the…
Parametric and nonparametric methods to generate time-varying surrogate data.
2009
We present both nonparametric and parametric approaches to generating time-varying surrogate data. Nonparametric and parametric approaches are based on the use of the short-time Fourier transform and a time-varying autoregressive model, respectively. Time-varying surrogate data (TVSD) can be used to determine the statistical significance of the linear and nonlinear coherence function estimates. Two advantages of the TVSD are that it keeps one from having to make an arbitrary decision about the significance of the coherence value, and it properly takes into account statistical significance levels, which may change with time. Our simulation examples and experimental results on blood pressure …
Discrete Maximum Principle for Galerkin Finite Element Solutions to Parabolic Problems on Rectangular Meshes
2004
One of the most important problems in numerical simulation is the preservation of qualitative properties of solutions of mathematical models. For problems of parabolic type, one of such properties is the maximum principle. In [5], Fujii analyzed the discrete analogue of the (continuous) maximum principle for the linear parabolic problems, and derived sufficient conditions guaranteeing its validity for the Galerkin finite element approximations built on simplicial meshes. In our paper, we present the sufficient conditions for the validity of the discrete maximum principle for the case of bilinear finite element space approximations on rectangular meshes.
TOPS-MODE approach for the prediction of blood-brain barrier permeation.
2004
The blood-brain barrier permeation has been investigated by using a topological substructural molecular design approach (TOPS-MODE). A linear regression model was developed to predict the in vivo blood-brain partitioning coefficient on a data set of 119 compounds, treated as the logarithm of the blood-brain concentration ratio. The final model explained the 70% of the variance and it was validated through the use of an external validation set (33 compounds of the 119, MAE = 0.33), a leave-one-out crossvalidation (q(2) = 0.65, S(press) = 0.43), fivefold full crossvalidation (removing 28 compounds in each cycle, MAE = 33, RMSE = 0.43) and the prediction of +/- values for an external test set …
Harmonic Balance Method and Stability of Discontinuous Systems
2019
The development of the theory of discontinuous dynamical systems and differential inclusions was not only due to research in the field of abstract mathematics but also a result of studies of particular problems in mechanics. One of the first methods, used for the analysis of dynamics in discontinuous mechanical systems, was the harmonic balance method developed in the thirties of the twentieth century. In our work, the results of analysis obtained by the method of harmonic balance, which is an approximate method, are compared with the results obtained by rigorous mathematical methods and numerical simulation.
RAMS-forecasts comparison of typical summer atmospheric conditions over the Western Mediterranean coast
2014
Abstract The Regional Atmospheric Modeling System (RAMS) has been used in order to perform a high-resolution numerical simulation of two meteorological events related to the most common atmospheric environments during the summer over the Western Mediterranean coast: mesoscale circulations and western synoptic advections. In this regard, we take advantage of the operational RAMS configuration running within the real-time forecasting system environment already implemented over this Mediterranean area, precisely in the Valencia Region and nearby areas. The attention of this paper is especially focused on identifying the main features of both events and the ability of the model in resolving the…
The superlattice model of lateral organization of membranes and its implications on membrane lipid homeostasis.
2008
AbstractMost biological membranes are extremely complex structures consisting of hundreds of different lipid and protein molecules. According to the famous fluid-mosaic model lipids and many proteins are free to diffuse very rapidly in the plane of the membrane. While such fast diffusion implies that different membrane lipids would be laterally randomly distributed, accumulating evidence indicates that in model and natural membranes the lipid components tend to adopt regular (superlattice-like) distributions. The superlattice model, put forward based on such evidence, is intriguing because it predicts that 1) there is a limited number of allowed compositions representing local minima in mem…
Model calculations of ion transport against its concentration gradient when the driving force is a pH difference across a charged membrane
1997
Model calculations of the steady-state ion transport against its external concentration gradient when the driving force of this transport is a pH difference across a charged membrane are presented. We have solved numerically the exact Nernst-Planck equations without any additional simplifying approximation, such as the Goldman constant field assumption within the membrane. The validity of this assumption for a broad range of pH values, and salt and membrane fixed charge concentrations was analyzed critically. The membrane characteristics studied are the ionic fluxes and the membrane potential. Special attention is paid to the physical mechanism which leads to the ion transport against the c…
The effect of wind on jumping distance in ski jumping – fairness assessed
2012
The special wind compensation system recently adopted by Federation Internationale de Ski (FIS; International Ski Federation) to consider the effects of changing wind conditions has caused some controversy. Here, the effect of wind on jumping distance in ski jumping was studied by means of computer simulation and compared with the wind compensation factors used by FIS during the World Cup season 2009/2010. The results showed clearly that the effect of increasing head/tail wind on jumping distance is not linear: +17.4 m/ − 29.1 m, respectively, for a wind speed of 3 m/s. The linear formula used in the trial period of the wind compensation system was found to be appropriate only for a limited…
Modeling and simulation of an offshore crane
2018
This paper presents a mathematical modeling of a crane system using robot modeling theory as well as the numerical simulation of the dynamics of a crane and a marine craft. The simulations are performed in SimulationX and Matlab Simulink. The simulation platform includes a SimulationX-model of the crane, a realistic model of a marine craft using the Marine Systems Simulator(MSS) and the hydrodynamic sea-keeping calculations (VERES program code). The simulation results show a very good picture of the dynamic behavior of the real crane in offshore environment and verify the validation and effectiveness of the presented modeling approach.