Search results for "Computer-aided"
showing 10 items of 416 documents
Metamodeling editor as a front end tool for a CASE shell
1992
Customizable Computer Aided Software Engineering (CASE) tools, often called CASE shells, are penetrating in the market. CASE shells provide a flexible environment to support a variety of information systems development methods. CASE shells are often cumbersome to use and in practice few people can model and implement methods in them. To overcome these problems we have developed a graphical metamodeling environment called MetaEdit and a method modeling interface to the CASE shell RAMATIC. Using this interface the methodology engineer can develop graphical models in RAMATIC's model definition language and then easily generate the resource files that control the operations of RAMATIC. MetaEdit…
Design of antitumor drugs targeting c-kit receptor by a new mixed ligand-structure based method
2020
An important challenge, in the medicinal chemistry field, is the research of novel forceful drugs to overcome tumor-acquired resistance. The c-Kit tyrosine kinase receptor (TKR) represents a suitable target for the carcinogenesis control of gastro-intestinal stromal (GIST), leukemia, and mastocytosis tumors; nevertheless, several hotspot mutations of the protein limit the efficacy of a few clinical administered TKRs inhibitors. In this study, a new in silico protocol based on ligand and structure-based combined method is proposed, with the aim to identify a set of new c-Kit inhibitors able to complex c-Kit mutated proteins. A recent and freely available web-server DRUDIT is used for the lig…
Computer-aided calculation of the molecular size of nondenatured proteins in pore-gradient gel electrophoresis
1991
A computer program written in Turbo C is described, which uses the two-step mathematical procedure published recently (Rothe, G. M., Electrophoresis 1988, 9, 307-316) to evaluate the molecular mass, Stokes' radius, spherical radius, and frictional coefficient of nondenatured proteins. The program runs on any IBM-PC or 100% compatible IBM-PC, provided the disk operating system MS-DOS or PC-DOS 3.0 or later has been installed. Functions that are permanently in use are accessible by menu. Storage and loading of data from disk and help instructions can be called by use of function keys. The program provides several tables into which inserted and calculated data is automatically integrated. Each…
Data Analytics in Healthcare: A Tertiary Study
2022
AbstractThe field of healthcare has seen a rapid increase in the applications of data analytics during the last decades. By utilizing different data analytic solutions, healthcare areas such as medical image analysis, disease recognition, outbreak monitoring, and clinical decision support have been automated to various degrees. Consequently, the intersection of healthcare and data analytics has received scientific attention to the point of numerous secondary studies. We analyze studies on healthcare data analytics, and provide a wide overview of the subject. This is a tertiary study, i.e., a systematic review of systematic reviews. We identified 45 systematic secondary studies on data analy…
Estimation of Purkinje trees from electro-anatomical mapping of the left ventricle using minimal cost geodesics
2015
The electrical activation of the heart is a complex physiological process that is essential for the understanding of several cardiac dysfunctions, such as ventricular tachycardia (VT). Nowadays, patient-specific activation times on ventricular chambers can be estimated from electro-anatomical maps, providing crucial information to clinicians for guiding cardiac radio-frequency ablation treatment. However, some relevant electrical pathways such as those of the Purkinje system are very difficult to interpret from these maps due to sparsity of data and the limited spatial resolution of the system. We present here a novel method to estimate these fast electrical pathways from the local activati…
Computer-aided detection of cerebral microbleeds in susceptibility-weighted imaging.
2014
Susceptibility-weighted imaging (SWI) is recognized as the preferred MRI technique for visualizing cerebral vasculature and related pathologies such as cerebral microbleeds (CMBs). Manual identification of CMBs is time-consuming, has limited reliability and reproducibility, and is prone to misinterpretation. In this paper, a novel computer-aided microbleed detection technique based on machine learning is presented: First, spherical-like objects (potential CMB candidates) with their corresponding bounding boxes were detected using a novel multi-scale Laplacian of Gaussian technique. A set of robust 3-dimensional Radon- and Hessian-based shape descriptors within each bounding box were then ex…
Interactive simulation of one-dimensional flexible parts
2006
Computer simulations play an ever growing role for the development of automotive products. Assembly simulation, as well as many other processes, are used systematically even before the first physical prototype of a vehicle is built in order to check whether particular components can be assembled easily or whether another part is in the way. Usually, this kind of simulation is limited to rigid bodies. However, a vehicle contains a multitude of flexible parts of various types: cables, hoses, carpets, seat surfaces, insulations, weatherstrips... Since most of the problems using these simulations concern one-dimensional components and since an intuitive tool for cable routing is still needed, w…
The “λ-medial axis”
2005
Medial axis is known to be unstable for nonsmooth objects. For an open set O, we define the weak feature size, wfs, minimum distance between Oc and the critical points of the function distance to Oc. We introduce the "lambda-medial axis" Mλ of O, a subset of the medial axis of O which captures the homotopy type of O when λ < wfs. We show that, at least for some "regular" values of λ, Mλ remains stable under Hausdorff distance perturbations of Oc.
TBSSvis: Visual Analytics for Temporal Blind Source Separation
2020
Temporal Blind Source Separation (TBSS) is used to obtain the true underlying processes from noisy temporal multivariate data, such as electrocardiograms. TBSS has similarities to Principal Component Analysis (PCA) as it separates the input data into univariate components and is applicable to suitable datasets from various domains, such as medicine, finance, or civil engineering. Despite TBSS’s broad applicability, the involved tasks are not well supported in current tools, which offer only text-based interactions and single static images. Analysts are limited in analyzing and comparing obtained results, which consist of diverse data such as matrices and sets of time series. Additionally, p…
Mixed Reality Annotation of Robotic-Assisted Surgery videos with real- time tracking and stereo matching
2023
Robotic-Assisted Surgery (RAS) is beginning to unlock its potential. However, despite the latest advances in RAS, the steep learning curve of RAS devices remains a problem. A common teaching resource in surgery is the use of videos of previous procedures, which in RAS are almost always stereoscopic. It is important to be able to add virtual annotations onto these videos so that certain elements of the surgical process are tracked and highlighted during the teaching session. Including virtual annotations in stereoscopic videos turns them into Mixed Reality (MR) experiences, in which tissues, tools and procedures are better observed. However, an MR-based annotation of objects requires trackin…