Search results for "Computer-aided"

QSAR methods for the discovery of new inflammatory bowel disease drugs

2013

Inflammatory bowel disease (IBD) represents an important class of chronic gastrointestinal tract disease. And although there are already several useful treatments to reduce and control the symptoms, there is still no cure. One drug discovery technique used is the computer-aided (in silico) discovery approach which has largely demonstrated efficacy. Computational techniques, when used in combination with traditional drug discovery methodology, greatly increase the chance of drug discovery in a sustainable and economical fashion.This review aims to provide the most recent and important advances of in silico IBD drug discovery. While this review is mainly focused on QSAR methods, especially th…

Molecular topology as a novel approach for drug discovery

2012

Molecular topology (MT) has emerged in recent years as a powerful approach for the in silico generation of new drugs. One key part of MT is that, in the process of drug design/discovery, there is no need for an explicit knowledge of a drug's mechanism of action unlike other drug discovery methods.In this review, the authors introduce the topic by explaining briefly the most common methodology used today in drug design/discovery and address the most important concepts of MT and the methodology followed (QSAR equations, LDA, etc.). Furthermore, the significant results achieved, from this approach, are outlined and discussed.The results outlined herein can be explained by considering that MT r…

Generation of narrowband antisymmetric lamb waves using a formed laser source in the ablative regime

2007

A formed laser source, using a four-element lenticular array, is used in the ablative regime to generate select, narrowband, acoustic plate waves. The arrangement of the array produces acoustical signals that have frequencies compatible with the response of the broadband capacitive air-coupled transducer used in this study. A simplified concept is presented to explain the effect of a line array source on the frequency content of acoustic waves. The analytical model for a point pulse surface displacement is derived from the point load solution to Lamb's problem. The point pulse displacement elements of a line array source are summed mathematically, taking into account all applicable propagat…

A Novel Approach of a Low-Cost UWB Microwave Imaging System with High Resolution Based on SAR and a New Fast Reconstruction Algorithm for Early-Stage…

2022

In this article, a new efficient and robust approach—the high-resolution microwave imaging system—for early breast cancer diagnosis is presented. The core concept of the proposed approach is to employ a combination of a newly proposed delay-and-sum (DAS) algorithm and the specific absorption rate (SAR) parameter to provide high image quality of breast tumors, along with fast image processing. The new algorithm enhances the tumor response by altering the parameter referring to the distance between the antenna and the tumor in the conventional DAS matrices. This adjustment entails a much clearer reconstructed image with short processing time. To achieve these aims, a high directional Vivaldi …

Optical rogue-wave-like extreme value fluctuations in fiber Raman amplifiers

2008

International audience; We report experimental observation and characterization of rogue wave-like extreme value statistics arising from pump-signal noise transfer in a fiber Raman amplifier. Specifically, by exploiting Raman amplification with an incoherent pump, the amplified signal is shown to develop a series of temporal intensity spikes whose peak power follows a power-law probability distribution. The results are interpreted using a numerical model of the Raman gain process using coupled nonlinear Schrödinger equations, and the numerical model predicts results in good agreement with experiment.

Asymmetric Single Point Incremental Forming of Sheet Metal

2005

The use of computers in manufacturing has enabled the development of several new sheet metal forming processes, which are based upon older technologies. This paper describes modifications that have been made to traditional forming methods such as conventional spinning and shear forming, forming processes in which deformation is localized. Recent advances have enabled this localized deformation to be accurately controlled and studied. Current developments have been focused on forming asymmetric parts using CNC technology, without the need for costly dies. Asymmetric Incremental Sheet Forming has the potential to revolutionize sheet metal forming, making it accessible to all levels of manufac…

How to best return the value of a function

1989

Regularization operators for natural images based on nonlinear perception models.

2006

Image restoration requires some a priori knowledge of the solution. Some of the conventional regularization techniques are based on the estimation of the power spectrum density. Simple statistical models for spectral estimation just take into account second-order relations between the pixels of the image. However, natural images exhibit additional features, such as particular relationships between local Fourier or wavelet transform coefficients. Biological visual systems have evolved to capture these relations. We propose the use of this biological behavior to build regularization operators as an alternative to simple statistical models. The results suggest that if the penalty operator take…

The finite element implementation of 3D fractional viscoelastic constitutive models

2018

Abstract The aim of this paper is to present the implementation of 3D fractional viscoelastic constitutive theory presented in Alotta et al., 2016 [1]. Fractional viscoelastic models exactly reproduce the time dependent behaviour of real viscoelastic materials which exhibit a long “fading memory”. From an implementation point of view, this feature implies storing the stress/strain history throughout the simulations which may require a large amount of memory. We propose here a number of strategies to effectively limit the memory required. The form of the constitutive equations are summarized and the finite element implementation in a Newton-Raphson integration scheme is described in detail. …

Rotation-Invariant Texture Retrieval via Signature Alignment Based on Steerable Sub-Gaussian Modeling

2008

This paper addresses the construction of a novel efficient rotation-invariant texture retrieval method that is based on the alignment in angle of signatures obtained via a steerable sub-Gaussian model. In our proposed scheme, we first construct a steerable multivariate sub-Gaussian model, where the fractional lower-order moments of a given image are associated with those of its rotated versions. The feature extraction step consists of estimating the so-called covariations between the orientation subbands of the corresponding steerable pyramid at the same or at adjacent decomposition levels and building an appropriate signature that can be rotated directly without the need of rotating the im…