Search results for "Condition"

A review of diagnostics and prognostics of low-speed machinery towards wind turbine farm-level health management

2016

Abstract Large wind farms are gaining prominence due to increasing dependence on renewable energy. In order to operate these wind farms reliably and efficiently, advanced maintenance strategies such as condition based maintenance are necessary. However, wind turbines pose unique challenges in terms of irregular load patterns, intermittent operation and harsh weather conditions, which have deterring effects on life of rotating machinery. This paper reviews the state-of-the-art in the area of diagnostics and prognostics pertaining to two critical failure prone components of wind turbines, namely, low-speed bearings and planetary gearboxes. The survey evaluates those methods that are applicabl…

Novel concept for stabilising a hydraulic circuit containing counterbalance valve and pressure compensated flow supply

2016

In this paper, a novel concept for stabilising a hydraulic system containing a counterbalance valve and a pressure compensated flow supply is presented. The concept utilizes a secondary circuit where a low-pass filtered value of the load pressure is generated and fed back to the compensator of the flow supply valve. The novel concept has been investigated theoretically and experimentally. A linear model has been developed to verify the improved stability conditions. The novel concept has been implemented on a single boom actuated by a cylinder. The results show that the pressure oscillations in an otherwise unstable system can be suppressed with the novel concept. This happens without any c…

Health Indicator for Low-Speed Axial Bearings Using Variational Autoencoders

2020

This paper proposes a method for calculating a health indicator (HI) for low-speed axial rolling element bearing (REB) health assessment by utilizing the latent representation obtained by variational inference using Variational Autoencoders (VAEs), trained on each speed reference in the dataset. Further, versatility is added by conditioning on the speed, extending the VAE to a conditional VAE (CVAE), thereby incorporating all speeds in a single model. Within the framework, the coefficients of autoregressive (AR) models are used as features. The dimensionality reduction inherent in the proposed method lowers the need of expert knowledge to design good condition indicators. Moreover, the sugg…

Multi-band identification for enhancing bearing fault detection in variable speed conditions

2020

Abstract Rolling element bearings are crucial components in rotating machinery, and avoiding unexpected breakdowns using fault detection methods is an increased demand in industry today. Variable speed conditions render a challenge for vibration-based fault diagnosis due to the non-stationary impact frequency. Computed order tracking transforms the vibration signal from time domain to the shaft-angle domain, allowing order analysis with the envelope spectrum. To enhance fault detection, the bearing resonance frequency region is isolated in the raw signal prior to order tracking. Identification of this region is not trivial but may be estimated using kurtosis-based methods reported in the li…

Reducing diagnostic turnaround times of exome sequencing for families requiring timely diagnoses

2017

IF 2.137; International audience; BACKGROUND AND OBJECTIVE:Whole-exome sequencing (WES) has now entered medical practice with powerful applications in the diagnosis of rare Mendelian disorders. Although the usefulness and cost-effectiveness of WES have been widely demonstrated, it is essential to reduce the diagnostic turnaround time to make WES a first-line procedure. Since 2011, the automation of laboratory procedures and advances in sequencing chemistry have made it possible to carry out diagnostic whole genome sequencing from the blood sample to molecular diagnosis of suspected genetic disorders within 50 h. Taking advantage of these advances, the main objective of the study was to impr…

Expression of NF-κB and IL-6 in oral precancerous and cancerous lesions: An immunohistochemical study.

2014

Background The purpose of this study was to evaluate the immunohistochemical expression of NF-κB and IL-6 in oral premalignant and malignant lesions and to investigate their possible correlation with the presence of subepithelial inflammation. Material and Methods Thirty two oral premalignant lesions, clinically compatible with leukoplakia or erythroplakia, were investigated. Microscopically, 11 of them showed hyperkeratosis and acanthosis (epithelial hyperplasia) and 21 showed dysplasia of varying degrees. Nine cases of OSCC and four control cases of normal oral mucosa were also included in the study. Immunohistochemical staining with NF-κB (p65) and IL-6 was performed. IL-6 and nuclear NF…

Effects of a 20-week high-intensity strength and sprint training program on tibial bone structure and strength in middle-aged and older male sprint a…

2017

This randomized, controlled, high-intensity strength and sprint training trial in middle-aged and older male sprint athletes showed significant improvements in mid-tibial structure and strength. The study reveals the adaptability of aging bone, suggesting that through a novel, intensive training stimulus it is possible to strengthen bones during aging. High-load, high-speed and impact-type exercise may be an efficient way of improving bone strength even in old age. We evaluated the effects of combined strength and sprint training on indices of bone health in competitive masters athletes, who serve as a group of older people who are likely to be able to participate in vigorous exercise of th…

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

2016

Aim Sirtuins are proteins that connect energy metabolism, oxidative stress and aging. Expression of heat shock proteins (Hsps) is regulated by heat shock factors (HSFs) in response to various environmental and physiological stresses, such as oxidative stress. Oxidative stress accumulates during aging which makes cells more prone to DNA damage. Although many experimental animal models have been designed to study the effects of knockdown or overexpression of sirtuins, HSFs and Hsps, little is known about how aging per se affects their expression. Here we study the impact of intrinsic aerobic capacity, aging and voluntary exercise on the levels of sirtuins, HSFs and Hsps in skeletal muscle. Me…

Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation

2016

The LDL family of receptors and its member low-density lipoprotein receptor-related protein 1 (LRP1) have classically been associated with a modulation of lipoprotein metabolism. Current studies, however, indicate diverse functions for this receptor in various aspects of cellular activities, including cell proliferation, migration, differentiation, and survival. LRP1 is essential for normal neuronal function in the adult CNS, whereas the role of LRP1 in development remained unclear. Previously, we have observed an upregulation of LewisX (LeX) glycosylated LRP1 in the stem cells of the developing cortex and demonstrated its importance for oligodendrocyte differentiation. In the current study…

2017

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a lethal genetic arrhythmia that manifests syncope or sudden death in children and young adults under stress conditions. CPVT patients often present bradycardia and sino-atrial node (SAN) dysfunction. However, the mechanism remains unclear. We analyzed SAN function in two CPVT families and in a novel knock-in (KI) mouse model carrying the RyR2R420Q mutation. Humans and KI mice presented slower resting heart rate. Accordingly, the rate of spontaneous intracellular Ca2+ ([Ca2+]i) transients was slower in KI mouse SAN preparations than in WT, without any significant alteration in the "funny" current (If ). The L-type Ca2+ current …