Search results for "Conducta"

showing 10 items of 611 documents

1996

The uses of atomic force microscopy, scanning tunneling microscopy, electron spectroscopic imaging, electron energy loss spectroscopy and low voltage, high resolution scanning electron microscopy in polymer research are reviewed

Conventional transmission electron microscopePolymers and PlasticsPolymer characterizationbusiness.industryChemistryGeneral Chemical EngineeringScanning confocal electron microscopyScanning capacitance microscopyCondensed Matter::Mesoscopic Systems and Quantum Hall EffectCondensed Matter::Materials ScienceOpticsMicroscopyScanning transmission electron microscopyScanning ion-conductance microscopyEnergy filtered transmission electron microscopyOptoelectronicsbusinessActa Polymerica
researchProduct

Programa de educación de las emociones: la con-vivencia. Evaluación de su eficacia en la conducta prosocial

2014

La educación de las emociones se sitúa en el marco de la psicología positiva (Seligman, 2000). En el desarrollo humano las emociones juegan un papel fundamental, especialmente, como los patrones de respuesta y ejercen un importante valor adaptativo, personal y social (Fredickson, 2001). Una respuesta emocional adaptada ante las situaciones cotidianas facilita la comunicación tanto con uno mismo y como con los demás. Así, la estimulación de las emociones positivas contribuye al desarrollo de la personalidad y a una mayor calidad de las relaciones interpersonales, favoreciendo una conducta más adaptada y prosocial. Diferentes estudios empíricos constatan que, tanto determinadas emociones, com…

ConvivenciaConducta prosocialEmocionesInfancia
researchProduct

Creatividad e imaginación: Análisis y evaluación del programa CREA para escolares en el seguimiento de 8-12 años.

2017

El trabajo que presentamos surge del deseo de profundizar en el análisis que, en el momento actual, plantea el fomento y desarrollo de la creatividad. Tras realizar un recorrido por diversos planteamientos teóricos y de investigación llevados a cabo en el ámbito creativo en el tiempo; se han abordado en un segundo momento, las aportaciones que al fomento de la creatividad se están llevando a cabo hoy, desde la investigación en el campo de la neurociencia y de la imaginación moral, para posteriormente, profundizar en la relación de esta con la conducta prosocial. En el apartado empírico, se ha llevado a cabo un análisis longitudinal a diversos grupos de escolares en el seguimiento de 8 y 12 …

Creatividad Pensamiento divergente Imaginación moral Imaginería cerebral Conducta prosocial Resolución de problemas Neurociencia Neuroeducación Educación Docencia.
researchProduct

Revista electrónica de investigación y evaluación educativa

2014

Resumen basado en el de la publicación Título, resumen y palabras clave en inglés y español Se pretende comprobar de forma experimental la asunción teórica que plantea la posibilidad de fomentar el potencial creativo de acuerdo con las condiciones ambientales que el medio proporciona. Para ello, se diseñó un programa psicoeducativo basado en cuentos infantiles, con el fin de estimular la capacidad creativa en niños de Educación Infantil. Para la medición de la creatividad se utilizaron la Batería Gráfica y Verbal de Test de Pensamiento Creativo de Torrance. Tras la aplicación del programa, los resultados arrojaron un incremento significativo en los niveles de creatividad verbal en el grupo …

Creativity children´s stories childhood schoollogical educativocreatividadcuentoconducta verbalEducation
researchProduct

Parental expectations and prosocial behavior of adolescents from low-income backgrounds. A cross-cultural comparison between three countries: Argenti…

2014

Parental expectations are influenced by cultural models, which in turn are subject to a great influence from historically fluctuating features of the socioeconomic background. Parental expectations seem to be linked to children’s social and emotional development in terms of empathy and prosocial behavior. The current study aims to (a) compare low-income adolescents’ perceptions of parental expectations of prosocial and antisocial behavior across three Latin countries (Argentina, Colombia, and Spain), (b) compare the empathy and prosocial behavior between the three countries, (c) compare the prosocial behavior between the three countries, and (d) study the effect of perceived parental expect…

Cultural StudiesLow incomeSocial Psychologymedia_common.quotation_subjectEmpathyLOW-INCOMEDevelopmental psychologyCIENCIAS SOCIALESPerceptionCROSS-CULTURAL STUDYSocioeconomic statusmedia_commonInfants CriançaConducta (Psicologia)PROSOCIAL BEHAVIOREducació en valorsOtras PsicologíaCross-cultural studiesPsicologíaProsocial behaviorAnthropologyScale (social sciences)Interpersonal Reactivity IndexPsychologySocial psychologyPARENTAL EXPECTATIONS
researchProduct

Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives.

2015

Abstract Premature stop codons are the result of nonsense mutations occurring within the coding sequence of a gene. These mutations lead to the synthesis of a truncated protein and are responsible for several genetic diseases. A potential pharmacological approach to treat these diseases is to promote the translational readthrough of premature stop codons by small molecules aiming to restore the full-length protein. The compound PTC124 (Ataluren) was reported to promote the readthrough of the premature UGA stop codon, although its activity was questioned. The potential interaction of PTC124 with mutated mRNA was recently suggested by molecular dynamics (MD) studies highlighting the importanc…

Cystic FibrosisNonsense mutationPeptide Chain Elongation TranslationalCystic Fibrosis Transmembrane Conductance RegulatorSettore BIO/11 - Biologia MolecolareMolecular Dynamics SimulationCFTR genechemistry.chemical_compoundStructure-Activity RelationshipPlasmidDrug DiscoveryTumor Cells CulturedCoding regionHumansGreen fluorescent proteinGenePharmacologyGeneticsMessenger RNAOxadiazolesNonsense mutationDose-Response Relationship DrugMolecular StructureDrug Discovery3003 Pharmaceutical ScienceOrganic ChemistryTranslational readthroughSettore CHIM/06 - Chimica OrganicaGeneral MedicinePTCs readthroughStop codonAtalurenSettore BIO/18 - GeneticachemistrySettore CHIM/03 - Chimica Generale E InorganicaCodon NonsenseCystic fibrosiMutationFluorinated oxadiazoleHeLa CellsEuropean journal of medicinal chemistry
researchProduct

Inhalable nano into micro dry powders for ivacaftor delivery: The role of mannitol and cysteamine as mucus-active agents.

2020

In this paper the innovative approach of Nano into micro (NiM9 was developed to produce Nanoparticles loaded Ivacaftor to incorporate into mannitol or mannitol/cysteamine micromatrices for drug pulmonary administration in CF. Nanoparticles composed by a mixture of two polyhydrohydroxyethtylaspartamide copolymers containing a loading of Ivacaftor of 15.5 % w/w were produced. These Nanoparticles were incorporated into microparticles to obtain NiM that were characterized in terms of size and size distribution, interaction with CF-AM by rheological and turbidimetric studies as well as by aerodynamic diameter measurements. Finally the activity of Ivacaftor into these NiM was evaluated by in vitr…

Cystic Fibrosisαβ-poly-(N-2-hydroxyethyl)-DL-aspartamide (PHEA) copolymer PHEA ivacaftor mucus-penetrating nanoparticle cell penetrating peptide nano into micro strategy. CysteamineDrug CompoundingPharmaceutical ScienceNanoparticleCystic Fibrosis Transmembrane Conductance Regulator02 engineering and technologyQuinolonesAminophenols030226 pharmacology & pharmacyIvacaftor03 medical and health scienceschemistry.chemical_compound0302 clinical medicineNano-Administration InhalationMucus-penetrating nanoparticlemedicineCopolymerAnimalsMannitolChloride Channel AgonistsCells CulturedExpectorantsCell penetrating peptideNano into micro strategyChemistry021001 nanoscience & nanotechnologyMucusRats Inbred F344IvacaftorCopolymer PHEADrug LiberationSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoMutationNanoparticlesCysteamineMannitolPowders0210 nano-technologyPeptidesαβ-poly-(N-2-hydroxyethyl)-DL-aspartamide (PHEA)medicine.drugNuclear chemistryInternational journal of pharmaceutics
researchProduct

HETEROCYCLIC COMPOUNDS AND MEDICAL USE THEREOF

2019

The present invention relates to heterocyclic nitrogen compounds, use thereof as a medicament and pharmaceutical compositions thereof. Furthermore, the invention provides combinations of compounds of general formula (I) with therapeutic agents, such as correctors, potentiators and amplifiers of dysfunctional proteins.

Cystic fibrosiCFTR correctorCystic fibrosis transmembrane conductance regulatorCFTRSettore CHIM/08 - Chimica FarmaceuticaF508del-CFTR
researchProduct

Impaired Transporter Associated with Antigen Processing (TAP) Function Attributable to a Single Amino Acid Alteration in the Peptide TAP Subunit TAP1

2003

Abstract The heterodimeric peptide transporter TAP belongs to the ABC transporter family. Sequence comparisons with the P-glycoprotein and cystic fibrosis transmembrane conductance regulator and the functional properties of selective amino acids in these ABC transporters postulated that the glutamic acid at position 263 and the phenylalanine at position 265 of the TAP1 subunit could affect peptide transporter function. To define the role of both amino acids, TAP1 mutants containing a deletion or a substitution to alanine at position 263 or 265 were generated and stably expressed in murine and human TAP1−/− cells. The different TAP1 mutants were characterized in terms of expression and funct…

Cytotoxicity ImmunologicMacromolecular SubstancesPhenylalanineImmunologyAntigen presentationGlutamic AcidATP-binding cassette transporterEndoplasmic ReticulumTransfectionCell LineMiceAdenosine TriphosphateATP Binding Cassette Transporter Subfamily B Member 3MHC class IAnimalsHumansImmunology and AllergyATP Binding Cassette Transporter Subfamily B Member 2Sequence DeletionAlaninechemistry.chemical_classificationAntigen PresentationbiologyHistocompatibility Antigens Class I3T3 CellsIntracellular MembranesTransporter associated with antigen processingMolecular biologyPeptide FragmentsCystic fibrosis transmembrane conductance regulatorAmino acidMice Inbred C57BLProtein SubunitsAmino Acid SubstitutionBiochemistrychemistryMutagenesis Site-Directedbiology.proteinATP-Binding Cassette TransportersTAP1Sequence AlignmentProtein BindingT-Lymphocytes CytotoxicThe Journal of Immunology
researchProduct

Characterization of Emergence of the Coulomb Blockade in a Pearl-Like DNA-AuNP Assembly

2023

Due to its superior self-assembly properties and vast functionalization pos-sibilities DNA has long been one of the most promising candidates forfabrication of nanoscale electrical components using molecular buildingblocks. There exist already many demonstrations on optical devices based onorganizing metallic nanoparticles (NP) via DNA self-assembly, but despite thepromises only few DNA based electrical devices or studies have been realizedso far. Here we study the gold NP conjugated and metallized DNA TX-tile-structure, which we recently showed to exhibit the room temperature Coulombblockade, the pre-requisition for a single electron transistor. The properties ofthe obtained Coulomb blocka…

Differential conductancechemistry.chemical_compoundMaterials sciencechemistryColloidal goldengineeringCoulomb blockadeNanotechnologyengineering.materialPearlDNACharacterization (materials science)Journal of Self Assembly and Molecular Electronics
researchProduct