Search results for "Continuous"

showing 10 items of 899 documents

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

2014

Background. Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether α-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affect patient outcome.Methods. This was a prospective, multinational pharmacokinetic point-prevalence study including 8 α-lactam antibiotics. Two blood samples were taken from each patient during a single dosing interval. The primary pharmacokinetic/pharmacodynamic targets were free antibiotic concentrations above the minimum inhibitory concentration (MIC) of the pathogen at both 50% (50% f TMIC) an…

MaleInternational CooperationAntibioticsadverse eventintensive care unitlaw.invention0302 clinical medicinemeropenemModels[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesadverse events; continuous infusion; extended infusion; pharmacodynamics; pharmacokinetics; Aged; Anti-Bacterial Agents; Bacterial Infections; Blood Chemical Analysis; Female; Humans; Intensive Care Units; International Cooperation; Male; Microbial Sensitivity Tests; Middle Aged; Models Statistical; Prospective Studies; Treatment Outcome; beta-Lactams; Critical Illnessantibiotic therapyProspective Studiesamoxicillin plus clavulanic acidComputingMilieux_MISCELLANEOUSbeta lactam antibioticAPACHE0303 health sciencescritical illneadultclinical trial3. Good healthcontinuous infusion; extended infusion; adverse events; pharmacokinetics; pharmacodynamics.antiinfective agent[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitologypriority journaldisease severitybeta-Lactamstatistical model Agedprospective studyHumanMicrobiology (medical)medicine.medical_specialtydrug exposureCritical IllnessImmunologybloodstream infectionMicrobial Sensitivity Testspiperacillin plus tazobactambeta-LactamsMicrobiologybeta lactam abdominal infection03 medical and health sciencescritically ill patientIntensive careAnti-Bacterial AgentcefepimepharmacodynamicsHumansDosingAdverse effectAgedModels Statistical030306 microbiologyOdds ratiomajor clinical studymortalityantibiotic sensitivityceftriaxoneProspective Studiemulticenter studypharmacodynamics.ampicillinBlood Chemical AnalysisCeftazidimeSettore MED/41 - AnestesiologiaInterquartile rangelaw030212 general & internal medicinepharmacokineticlung infectionMicrobial Sensitivity TestarticleBacterial InfectionsMiddle AgedStatisticalcontinuous infusionIntensive care unitAnti-Bacterial Agentsextended infusionIntensive Care UnitsInfectious DiseasesTreatment Outcomeadverse events; continuous infusion; extended infusion; pharmacodynamics; pharmacokinetics; Aged; Anti-Bacterial Agents; Bacterial Infections; Blood Chemical Analysis; Female; Humans; Intensive Care Units; International Cooperation; Male; Microbial Sensitivity Tests; Middle Aged; Models Statistical; Prospective Studies; Treatment Outcome; beta-Lactams; Critical Illness; Microbiology (medical); Infectious Diseasescefazolin[SDV.IMM]Life Sciences [q-bio]/Immunologyblood samplingFemalepharmacokineticsmedicine.drugmedicine.drug_classprevalencedoripenemminimum inhibitory concentrationBacterial InfectionInternal medicinemedicinecontrolled studyblood analysibusiness.industryBlood Chemical Analysiadverse eventsSurgerypharmacodynamicdrug blood levelbusiness
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Unconscious integration of multisensory bodily inputs in the peripersonal space shapes bodily self-consciousness

2017

International audience; Recent studies have highlighted the role of multisensory integration as a key mechanism of self-consciousness. In particular, integration of bodily signals within the peripersonal space (PPS) underlies the experience of the self in a body we own (self-identification) and that is experienced as occupying a specific location in space (self-location), two main components of bodily self-consciousness (BSC). Experiments investigating the effects of multisensory integration on BSC have typically employed supra-threshold sensory stimuli, neglecting the role of unconscious sensory signals in BSC, as tested in other consciousness research. Here, we used psychophysical techniq…

MaleLinguistics and LanguageUnconscious mindVisual perceptionConsciousnessCognitive Neurosciencemedia_common.quotation_subject[ SCCO.PSYC ] Cognitive science/PsychologyExperimental and Cognitive PsychologySensory systemPeripersonal spaceAffect (psychology)Visual awarenessLanguage and Linguistics050105 experimental psychologyPersonal Space03 medical and health sciences0302 clinical medicinePhysical StimulationPerceptionBody ImageDevelopmental and Educational PsychologyMultisensory integrationHumans[ SHS.ECO ] Humanities and Social Sciences/Economies and financesContinuous flash suppression0501 psychology and cognitive sciencesContinuous flash suppressionmedia_commonSensory stimulation therapy[SCCO.NEUR]Cognitive science/Neuroscience05 social sciencesMultisensory integrationAwarenessProprioception16. Peace & justice[SHS.ECO]Humanities and Social Sciences/Economics and FinanceSelf ConceptTouch Perception[ SCCO.NEUR ] Cognitive science/Neuroscience[SCCO.PSYC]Cognitive science/PsychologyVisual PerceptionFemaleConsciousnessPsychologyBodily self-consciousness030217 neurology & neurosurgeryCognitive psychology
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Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010

2012

The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6,031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18,873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2…

MalePediatricsCross-sectional study95% CI 1.19-1.59) from 1998-2000 to 2007-2010but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthmaAbstract The prevalence of asthma increased worldwide until the 1990stemporal trendsSurveys and QuestionnairesEpidemiologySurveys and QuestionnaireMedicineasthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in ItalyYoung adultrespectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38from 10.1% to 13.9% and from 16.8% to 25.8%education.field_of_studyAllergic rhinitis; Asthma; Epidemiology; Prevalence; Temporal trends; Wheezing;medicine.diagnostic_testSmokingthe median prevalence of current asthmaallergic rhinitis asthma epidemiology prevalence temporal trends wheezingItalyAbstract The prevalence of asthma increased worldwide until the 1990s but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010; n=10494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010 the median prevalence of current asthma wheezing and allergic rhinitis increased from 4.1% to 6.6% from 10.1% to 13.9% and from 16.8% to 25.8% respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38 95% CI 1.19-1.59) from 1998-2000 to 2007-2010 mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs asthma prevalence has increased by 38% in parallel with a similar increase in asthma-like symptoms and allergic rhinitis.mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrssymbolsasthma prevalence has increased by 38%FemaleepidemiologyHumanPulmonary and Respiratory MedicineAdult494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010in parallel with a similar increase in asthma-like symptoms and allergic rhinitismedicine.medical_specialtyRhinitis Allergic PerennialPopulationprevalencethe Italian Study on Asthma in Young Adults (ISAYA) (1998-2000Settore MED/10 - Malattie Dell'Apparato Respiratorio031)and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010Settore MED/01 - Statistica Medicasymbols.namesakeYoung AdultAllergic rhinitiHumansRespiratory soundsPoisson regressioneducationAsthmaRespiratory SoundsCross-Sectional Studieallergic rhinitisbusiness.industrywheezingwheezing and allergic rhinitis increased from 4.1% to 6.6%Rhinitis Allergic Seasonalasthmain the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993medicine.disease873)Cross-Sectional Studiesn=10Relative riskTemporal trendRespiratory Soundn=6n=18business
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Continuous electroencephalography in a mixed non-neurological intensive care population, an observational study.

2016

Abstract Purpose Continuous electroencephalography (cEEG) improves monitoring of the brain in unconscious patients, but implementation at ICU is difficult. The present investigation shows a way to introduce cEEG at an anesthesiological ICU and discusses the first experiences. Materials and methods The study analyzed the feasibility of cEEG, assessed the interpretable cEEG time, importance of automatic seizure detection, the incidence of seizures, the predominant background EEG activity, incidence of delirium and mortality. Results Fifty-three cEEGs of 50 patients with a median interpretable length of 24 hours [IQR 20 to 42 hours] were recorded. One patient had status epilepticus, while 5 pa…

MalePediatricsmedicine.medical_specialtyCritical CareContinuous electroencephalographyPopulationStatus epilepticusCritical Care and Intensive Care Medicine03 medical and health sciences0302 clinical medicineOutcome predictorSeizuresIntensive careGermanyOutcome Assessment Health CaremedicineHumanseducationMonitoring Physiologiceducation.field_of_studybusiness.industryIncidence (epidemiology)030208 emergency & critical care medicineElectroencephalographyMiddle AgedIntensive Care UnitsAnesthesiaDeliriumObservational studyFemalemedicine.symptombusiness030217 neurology & neurosurgeryJournal of critical care
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Standardized weaning of infants <32 weeks of gestation from continuous positive airway pressure – a feasibility study

2015

The practice of weaning premature infants from continuous positive airway pressure (CPAP) varies considerably and is usually performed without written standards. In this study, the feasibility of a standardized weaning approach was evaluated. In a quasi-experimental design, data from a prospective, post-intervention cohort (n=41) were compared to data from a pre-intervention cohort (n=36). Standardized weaning was feasible but no significant differences in short-term respiratory outcomes were observed. Weaning from CPAP was achieved at 32.1 ± 1.6 (post-intervention) versus 32.5 ± 2.3 weeks (pre-intervention) postmenstrual age. More rigorous, large-scale clinical trials are necessary before …

MalePediatricsmedicine.medical_specialtyTime Factorsmedicine.medical_treatment03 medical and health sciences0302 clinical medicine030225 pediatricsmedicineHumansWeaning030212 general & internal medicineContinuous positive airway pressureContinuous Positive Airway Pressurebusiness.industryInfant NewbornPostmenstrual AgeInfantObstetrics and GynecologyEvidence-based medicineClinical trialPractice Guidelines as TopicPediatrics Perinatology and Child HealthCohortFeasibility StudiesGestationFemalebusinessVentilator WeaningInfant PrematureThe Journal of Maternal-Fetal & Neonatal Medicine
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Assessment of the awareness and management of sleep apnea syndrome in acromegaly. The COM.E.TA (Comorbidities Evaluation and Treatment in Acromegaly)…

2011

In 2007 the Italian COM.E.T.A. (COMorbidities Evaluation and Treatment in Acromegaly) study group started to assess the application in a clinical setting of the Versailles criteria for management of acromegaly complications by a first questionnaire focusing on cardiovascular co-morbidities. A further questionnaire on sleep apnea syndrome (SAS) was delivered by the COM.E.T.A. study group to 107 endocrine centers in Italy. The results of our survey suggest that SAS is a well-known comorbidity even if its estimated prevalence is lower than in the literature. Polysomnography is the preferred tool for diagnosis. Control of SAS is considered relevant both for quality of life and co-morbidities. C…

MalePediatricsmedicine.medical_specialtymedicine.medical_treatmentEndocrinology Diabetes and MetabolismPolysomnographyPolysomnographyComorbiditysomatostatin analogs; acromegaly; sleep apnea syndromeSettore MED/13 - EndocrinologiaSomatostatin analogEndocrinologySleep Apnea SyndromesQuality of lifeAcromegaly; Sleep apnea syndrome; Somatostatin analogs;PhysiciansSurveys and QuestionnairesAcromegalymedicinePrevalenceHumansContinuous positive airway pressuremedicine.diagnostic_testbusiness.industrySleep apneaAwarenessFocus Groupssleep apneamedicine.diseaseComorbidityAcromegaly; Sleep apnea syndrome; Somatostatin analogsAcromegaly; Sleep ApneaSleep apnea syndromeItalySomatostatin analogsAcromegalyPhysical therapyCOM.E.TA.FemaleClinical Competencebusiness
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Weaning Premature Infants from Nasal Continuous Positive Airway Pressure - Current Practice and Scientific Evidence.

2017

Abstract Objective In the past decade, a number of trials have been conducted to determine the optimal strategy of weaning premature infants from nasal continuous airway pressure (nCPAP). However, a paucity of information exists on how weaning is actually performed in clinical routine. Aim of this study was to investigate the current practice of weaning premature infants from nCPAP in Germany. Methods An online survey was performed in German tertiary care neonatal units. Results All 160 German tertiary care units were contacted. Replies were retrieved from 85/160 (53%) units, of which 83/160 (52%) completed the questionnaire. 66/83 (80%) respondents indicated to wean without the use of form…

MalePediatricsmedicine.medical_specialtymedicine.medical_treatmentInfant Premature DiseasesTertiary careDecision Support TechniquesTertiary Care Centers03 medical and health sciences0302 clinical medicineRisk Factors030225 pediatricsGermanySurveys and QuestionnairesmedicineWeaningHumans030212 general & internal medicineContinuous positive airway pressureContinuous Positive Airway Pressurebusiness.industryInfant NewbornClinical routineClinical trialTreatment OutcomeCurrent practicePediatrics Perinatology and Child HealthFemaleHigh flowbusinessAirwayVentilator WeaningKlinische Padiatrie
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Immediate effects of active versus passive scapular correction on pain and pressure pain threshold in patients with chronic neck pain.

2012

OBJECTIVE: The purpose of this study was to investigate the effect of active vs passive scapular correction on pain and pressure pain threshold at the most symptomatic cervical segment in patients with chronic neck pain. METHODS: Twenty-three volunteers with chronic, idiopathic neck pain were recruited (age, 38.9 ± 14.4 years; sex [man/woman], 3/20; Neck Disability Index, 28.1% ± 9.9%). Subjects were randomly allocated to 2 groups: active scapular correction or passive scapular correction. Pressure pain threshold and pain intensity rated on a numerical rating scale during a posteroanterior glide over the most symptomatic cervical segment were measured before and immediately after the active…

MalePressure painSeverity of Illness Indexlaw.inventionMagnetic Resonance Imaging/methodsRandomized controlled trialScapulalawManipulation Spinal/methodsYoung adultPain MeasurementNeck painBrain MappingNeck PainPain Perception/physiologyManipulation ChiropracticNeck Pain/diagnosisPain PerceptionMotion Therapy Continuous Passive/methodsmusculoskeletal systemMagnetic Resonance ImagingManipulation Chiropractic/methodsScapulaTreatment OutcomePatient SatisfactionManipulation OrthopedicFemalemedicine.symptomChronic PainChronic Pain/diagnosismusculoskeletal diseasesAdultManipulation SpinalPain Thresholdmedicine.medical_specialtyAdolescentYoung AdultSeverity of illnessmedicinePressureHumansIn patientManipulation Orthopedic/methodsPain Threshold/physiologyReferred painbusiness.industryMotion Therapy Continuous PassiveSurgeryPatient Satisfaction/statistics & numerical dataChiropracticsbusinessFollow-Up StudiesJournal of manipulative and physiological therapeutics
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Individualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE): a randomised controlled trial

2018

Background The effects of individualised perioperative lung-protective ventilation (based on the open-lung approach [OLA]) on postoperative complications is unknown. We aimed to investigate the effects of intraoperative and postoperative ventilatory management in patients scheduled for abdominal surgery, compared with standard protective ventilation. Methods We did this prospective, multicentre, randomised controlled trial in 21 teaching hospitals in Spain. We enrolled patients who were aged 18 years or older, were scheduled to have abdominal surgery with an expected time of longer than 2 h, had intermediate-to-high-risk of developing postoperative pulmonary complications, and who had a bod…

MalePulmonary and Respiratory Medicinemedicine.medical_treatmentPopulationPerioperative Carelaw.inventionPositive-Pressure Respiration03 medical and health sciencesPostoperative Complications0302 clinical medicineRandomized controlled trial030202 anesthesiologylawOxygen therapyAbdomenmedicineHumansProspective Studies030212 general & internal medicineContinuous positive airway pressureeducationLungAgedMechanical ventilationeducation.field_of_studybusiness.industryPerioperativeMiddle AgedRespiration Artificialrespiratory tract diseasesTreatment OutcomeSpainAnesthesiaBreathingFemalebusinessAbdominal surgery
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Long-term variations of arterial stiffness in patients with obesity and obstructive sleep apnea treated with continuous positive airway pressure

2020

BackgroundObstructive sleep apnea (OSA) is associated with cardiovascular co-morbidities and mortality. Arterial stiffness is an independent predictor of cardiovascular risk and mortality, and is influenced by the presence of OSA and related comorbidities. There is a paucity of data regarding long-term evolution of arterial stiffness in CPAP-treated OSA patients. We aimed to prospectively study long term PWV variations and determinants of PWV deterioration.MethodsIn a prospective obese OSA cohort, at time of diagnosis and after several years of follow-up we collected arterial stiffness measured by carotid-femoral pulse wave velocity (PWV), clinical and metabolic parameters, and CPAP adheren…

MalePulmonologyApneaPhysiologymedicine.medical_treatmentBlood PressurePolysomnography030204 cardiovascular system & hematologyVascular Medicine[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tractStiffnessCohort StudiesMedical ConditionsMathematical and Statistical TechniquesEndocrinology0302 clinical medicineRisk FactorsMedicine and Health SciencesContinuous positive airway pressurePulse wave velocitySleep Apnea Obstructiveeducation.field_of_studyMultidisciplinaryContinuous Positive Airway Pressuremedicine.diagnostic_testPharmaceuticsStatisticsQlongitudinal studyRSleep apneaBlood Pressure Monitoring AmbulatoryMiddle Aged[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system3. Good healthCardiovascular TherapyNeurologyPhysiological ParametersCardiovascular DiseasesPhysical SciencesHypertensioncardiovascular systemCardiologysleep disordered breathing.MedicineFemaleResearch Articlecirculatory and respiratory physiologymedicine.medical_specialtySleep ApneaEndocrine Disorderspulse wave velocityPolysomnographyScienceMaterials ScienceMaterial PropertiesPopulationSettore MED/10 - Malattie Dell'Apparato RespiratorioResearch and Analysis MethodsRespiratory Disorders03 medical and health sciencesVascular StiffnessDrug Therapy[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicineDiabetes MellitusmedicineMechanical PropertiesHumansObesityStatistical Methodseducationbusiness.industryBody WeightBiology and Life Sciencesmedicine.diseaserespiratory tract diseasesObstructive sleep apneaBlood pressure030228 respiratory systemMetabolic DisordersMultivariate AnalysisArterial stiffness[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tractSleep DisordersbusinessMathematicsPLOS ONE
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