6533b82efe1ef96bd1293ea6
RESEARCH PRODUCT
Long-term variations of arterial stiffness in patients with obesity and obstructive sleep apnea treated with continuous positive airway pressure
Jean-christian BorelMarie Joyeux-faureLouis-marie GalerneauJean-louis PépinIngrid Jullian-desayesMarisa BonsignoreMeriem BenmeradSébastien BaillyRenaud Tamisiersubject
MalePulmonologyApneaPhysiologymedicine.medical_treatmentBlood PressurePolysomnography030204 cardiovascular system & hematologyVascular Medicine[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tractStiffnessCohort StudiesMedical ConditionsMathematical and Statistical TechniquesEndocrinology0302 clinical medicineRisk FactorsMedicine and Health SciencesContinuous positive airway pressurePulse wave velocitySleep Apnea Obstructiveeducation.field_of_studyMultidisciplinaryContinuous Positive Airway Pressuremedicine.diagnostic_testPharmaceuticsStatisticsQlongitudinal studyRSleep apneaBlood Pressure Monitoring AmbulatoryMiddle Aged[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system3. Good healthCardiovascular TherapyNeurologyPhysiological ParametersCardiovascular DiseasesPhysical SciencesHypertensioncardiovascular systemCardiologysleep disordered breathing.MedicineFemaleResearch Articlecirculatory and respiratory physiologymedicine.medical_specialtySleep ApneaEndocrine Disorderspulse wave velocityPolysomnographyScienceMaterials ScienceMaterial PropertiesPopulationSettore MED/10 - Malattie Dell'Apparato RespiratorioResearch and Analysis MethodsRespiratory Disorders03 medical and health sciencesVascular StiffnessDrug Therapy[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicineDiabetes MellitusmedicineMechanical PropertiesHumansObesityStatistical Methodseducationbusiness.industryBody WeightBiology and Life Sciencesmedicine.diseaserespiratory tract diseasesObstructive sleep apneaBlood pressure030228 respiratory systemMetabolic DisordersMultivariate AnalysisArterial stiffness[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tractSleep DisordersbusinessMathematicsdescription
BackgroundObstructive sleep apnea (OSA) is associated with cardiovascular co-morbidities and mortality. Arterial stiffness is an independent predictor of cardiovascular risk and mortality, and is influenced by the presence of OSA and related comorbidities. There is a paucity of data regarding long-term evolution of arterial stiffness in CPAP-treated OSA patients. We aimed to prospectively study long term PWV variations and determinants of PWV deterioration.MethodsIn a prospective obese OSA cohort, at time of diagnosis and after several years of follow-up we collected arterial stiffness measured by carotid-femoral pulse wave velocity (PWV), clinical and metabolic parameters, and CPAP adherence. Univariate and multivariate analyses were performed in order to determine contributing factors.ResultsSeventy two OSA patients (men: 52.8%, median age: 55.8 years and median BMI of 38.5 kg/m2) with a prevalence of hypertension: 58.3%, type 2 diabetes: 20.8%, hypercholesterolemia: 33.3%, current or past smoking: 59.7%, were evaluated after a median follow-up of 7.4 [5.8; 8.3] years. Over the period of follow-up, the median increase in PWV was 1.34 [0.10; 2.37] m/s. In multivariate analysis, the increase in PWV was associated with older age (10 extra years was associated with a 5.24 [1.35; 9.12] % increase in PWV) and hypertension (a significant increase in PWV of 8.24 [1.02; 15.57] %). No impact of CPAP adherence on PWV evolution was found.ConclusionPWV progression in CPAP-treated OSA patients is mainly related to pre-existing cardio-metabolic comorbidities and not influenced by CPAP adherence. In this high cardiovascular risk population, it is crucial to associated weight management and exercise with CPAP treatment.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-08-05 | PLOS ONE |