0000000000422279
AUTHOR
Meriem Benmerad
Arterial stiffness in obese CPAP-treated obstructive sleep apnea (OSA): A seven years prospective longitudinal study
Introduction: Arterial stiffness measured by carotid-femoral pulse wave velocity (PWV) is elevated in severe OSA. A 1m/s increase in PWV is associated with a 15% increased risk of mortality. There is a paucity of data regarding long term evolution of PWV in CPAP-treated OSA. Aims: To measure PWV evolution in CPAP-treated OSA. Methods: In a prospective obese OSA cohort, we collected PWV, clinical and biological metabolic data, incident cardiovascular events and CPAP adherence at time of diagnosis and after at least 5-year follow-up. Results: 72 OSA (men: 52.8%, median age: 55.8 years and median BMI of 38.5 kg/m2) with a high prevalence of hypertension: 58.3%, Type 2 diabetes: 20.8%, hypercho…
Rigidité artérielle chez les patients obèses traités par PPC pour un syndrome d’apnées obstructives du sommeil (SAOS) : étude longitudinale prospective sur sept ans
Introduction La rigidite arterielle mesuree par la vitesse de l’onde de pouls carotido-femorale (VOP) est elevee dans le SAOS severe. Une augmentation de 1 m/s de VOP est associee a un risque accru de 15 % de mortalite. Une diminution de la VOP a ete decrite apres quelques mois de traitement par pression positive continue (PPC), mais il existe peu de donnees concernant l’evolution a long terme de la VOP dans le SAOS traite par PPC [1] . L’objectif de l’etude est de mesurer l’evolution et les determinants de la VOP dans le SOAS traite par PPC. Methodes Dans une cohorte prospective d’obeses avec un SAOS, nous avons recueilli des donnees cliniques et biologiques ainsi que les donnees de VOP, d…
Long-term variations of arterial stiffness in patients with obesity and obstructive sleep apnea treated with continuous positive airway pressure
BackgroundObstructive sleep apnea (OSA) is associated with cardiovascular co-morbidities and mortality. Arterial stiffness is an independent predictor of cardiovascular risk and mortality, and is influenced by the presence of OSA and related comorbidities. There is a paucity of data regarding long-term evolution of arterial stiffness in CPAP-treated OSA patients. We aimed to prospectively study long term PWV variations and determinants of PWV deterioration.MethodsIn a prospective obese OSA cohort, at time of diagnosis and after several years of follow-up we collected arterial stiffness measured by carotid-femoral pulse wave velocity (PWV), clinical and metabolic parameters, and CPAP adheren…