Search results for "Cordyceps"
showing 6 items of 6 documents
Cordycepin is an immunoregulatory active ingredient of Cordyceps sinensis.
2008
We have reported that cordycepin, an adenosine derivative from the fungus Cordyceps, increased interleukin (IL)-10 expression, decreased IL-2 expression and suppressed T lymphocyte activity. In the present study, we further characterized the regulatory effects of cordycepin on human immune cells. Moreover, a traditional Chinese drug, Cordyceps sinensis (CS) that contains cordycepin, was also investigated. Cytometric Bead Array (CBA) was used to determine the concentrations of IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, TNF-alpha and IFN-gamma in culture of peripheral blood mononuclear cells (PBMCs). The results showed that both cordycepin and CS up-regulated IL-10, IL-1beta, IL-6,…
Phylogeny and morphology of Hirsutella tunicata sp. nov. (Ophiocordycipitaceae), a novel mite parasite from Peru
2013
Abstract A new species of Hirsutella was isolated from unidentified mites on Petri plates inoculated with soil and root fragments collected from asparagus rhizosphere at Viru, Northern Peru. The fungus differs from other Hirsutella species by an envelope surrounding the conidium, conidia dimension and DNA sequences. In PDA cultures, the mycelium produced aerial hyphae with conidiogenous cells mainly at right angles, occasionally showing a secondary conidiophore. The solitary conidia are cymbiform, slightly apiculate, 5.0–6.0 × 3.0–4.0 μm. Phylogenetic analyses with partial rRNA and β-tubulin gene sequences confirmed the fungus as an Hirsutella (Ophiocordycipitaceae). Closest species shown b…
Activity of Cordycepin From Cordyceps sinensis Against Drug-Resistant Tumor Cells as Determined by Gene Expression and Drug Sensitivity Profiling
2021
Cordycepin is one of the substantial components of the parasitic fungus Cordyceps sinensis as well as other Cordyceps species. It exerts various effects such as antimetastatic, antiinflammatory, antioxidant, and neuroprotective activities. Assorted studies revealed in vitro and in vivo anticancer influence of cordycepin and put forward its potential for cancer therapy. However, the role of multidrug resistance-associated mechanisms for the antitumor effect of cordycepin has not been investigated in great detail thus far. Therefore, we searched cordycepin’s cytotoxicity with regard to well-known anticancer drug resistance mechanisms, including ABCB1, ABCB5, ABCC1, ABCG2, EGFR, and TP53, and…
Über die mikrobiologische Umwandlung N-haltiger Substrate. 4. Mitt.: Über die mikrobiologische Umwandlung von 5-Hydroxyindol durch Claviceps purpurea…
1968
Aus 5-Hydroxyindol wird durch den Claviceps purpurea-Stamm 47 A 5-Hydroxytryptophan und ω-N-Acetyl-5-hydroxy-tryptophan, durch Cordyceps militaris ω-N-Acetyl-5-hydroxytryptophan und ω-N-Acetyl-serotonin, durch Aspergillus oryzae nur ω-N-Acetyl-serotonin in der Schuttelkultur gebildet. 5-Hydroxyindole, added to submerged cultures, is converted into 5-hydroxytryptophan and ω-N-acetyl-5-hydroxytryptophan by Claviceps purpurea strain 47 A; into ω-N-acetyl-5-hydroxytryptophan and ω-N-acetyl-serotonin by Cordiceps militaris; and only into-ω-N-acetyl-serotonin by Aspergillus oryzae.
Über die mikrobiologische Umwandlung N-haltiger Substrate. 3. Mitt.: Über die Konstitutionsaufklärung von Umwandlungsprodukten des 5-Hydroxyindols du…
1968
In Schuttelkulturen von Cordyceps militaris entstehen aus 5-Hydroxyindol zwei neue Substanzen, die nach Chromatographie an Polyamidsaulen und nachfolgender Isolierung auf Grund ihres chemischen Verhaltens gegenuber Diazomethan sowie ihrer Elementaranalysen, IR-, Massen-und NMR-Spektren als ω-N-Acetyl-5-hydroxy-tryptophan und ω-N-Acetyl-serotonin identifiziert wurden. Two new substances are produced in submerged cultures of Cordyceps militaris fed with 5-hydroxyindole. These substances, separated by column chromatography with polyamide and isolated afterwards, have been identified as ω-N-acetyl-5-hydroxytryptophan and ω-N-acetyl-serotonin by their reaction with diazomethane, by elementary an…
Zum Tryptophanabbau bei Cordyceps militaris-Stämmen in saprophytischen Kulturen
1973
Summary The degradation of tryptophan in two strains of the Cordyceps miliraris Link in saprophytic culture was examined: both fungi showed different behavior patterns. In the strain I all the tryptophan is subject to lateral catenoid oxidation and the metabolite of this catabolism process are fixed. In strain II under identical experimental conditions the tryptophan is decomposed by the “Ehrlich-mechanism”. Independently of the above, N-acetylization reactions occur in both strains. Here both the L-isomers and the D-isomers of tryptophan are metabolized. Both isomers can be acetylized.