Search results for "Core"

Eresus kollari (Araneae: Eresidae) calls for heathland management

2011

Northwest Europe’s largest heather-dominated sandy habitats are located in the nature reserve Lu¨neburgerHeide, Germany. Yet, even these appear to be losing their ability to support some of their stenotopic species such as theladybird spider, Eresus kollari Rossi 1846, and are thus becoming increasingly important for the preservation of thesespecies. The habitat requirements of this endangered spider species were investigated in order to obtain data that will helpstabilize the last remnants of the species’ population in northwest Germany. Several heathland habitats were surveyed bypitfall trapping during the mate-search period of the males. Two statistical methods were applied: logistic reg…

Genetic architecture of circulating lipid levels

2011

Serum concentrations of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and total cholesterol (TC) are important heritable risk factors for cardiovascular disease. Although genome-wide association studies (GWASs) of circulating lipid levels have identified numerous loci, a substantial portion of the heritability of these traits remains unexplained. Evidence of unexplained genetic variance can be detected by combining multiple independent markers into additive genetic risk scores. Such polygenic scores, constructed using results from the ENGAGE Consortium GWAS on serum lipids, were applied to predict lipid levels in an independen…

Molecular Characterization of Relapsed Core-Binding Factor (CBF) Acute Myeloid Leukemia (AML)

2015

Abstract Background: CBF-AML is defined by recurrent genetic abnormalities which encompass t(8;21)(q22;q22), inv(16)(p13.1q22) or less frequently t(16;16)(p13.1;q22). Most frequent secondary chromosome aberrations in t(8;21) AML are del(9q) or loss of a sex chromosome, and in inv(16)/t(16;16) AML trisomy 22 or trisomy 8. At the molecular level mutations involving KIT, FLT3, or NRAS were identified as recurrent lesions in CBF-AML. However, the underlying genetic alterations which might trigger relapse in CBF-AML are not well delineated. Thus, the aim of our study was to characterize the clonal architecture of relapsed CBF-AML. Methods: We performed mutational profiling (KIT, FLT3-ITD, FLT3-T…

Synthesis, Crystal Structure, and Magnetic Properties of an Octanuclear Nickel(II) Complex with ahexahedro-Ni8 Core

1996

Preparation of hepatitis C virus structural and non-structural protein fragments and studies of their immunogenicity

2006

Abstract Plasmids pQE-60 and pQE-30 containing 6× His-tag sequence were used for expression of fragments of HCV structural and non-structural proteins in Escherichia coli (E. coli). The following fragments were used: core (1–98 aa), NS3 (202–482 aa), and tetramer of hypervariable region 1 (HVR1) of E2 protein. The constructed plasmids directed high levels of expression of HCV proteins in E. coli JM109. After purification by the metal-affinity chromatography on nickel–nitrilotriacetic acid (Ni–NTA) agarose, the His-tagged HCV proteins were used for immunization of BALB/c mice. All three proteins were able to induce high levels of specific antibodies and, in the case of the NS3 and HVR1 tetra…

Indentation of rigidly supported sandwich beams with foam cores exhibiting non-linear compressive behaviour.

2011

A generalized analytical approach to investigate the indentation of sandwich beams under concentrated loads is presented, based on the Winkler foundation theory. A segment-wise model is implemented to the case of fully backed sandwich beams with polymeric foam cores exhibiting generic non-linear compressive behaviours. Closed-form analytical solutions of the indentation curve are obtained for simplified foam compression behaviours: elastic-perfectly-plastic, bilinear and bilinear-perfectly-plastic. Analytical predictions are compared with experimental data from sandwiches employing foam cores with peculiar non-linear behaviours. The proposed models are found to give a better match of the e…

How to standardize (if you must)

2017

In many situations we are interested in appraising the value of a certain characteristic for a given individual relative to the context in which this value is observed. In recent years this problem has become prominent in the evaluation of scientific productivity and impact. A popular approach to such relative valuations consists in using percentile ranks. This is a purely ordinal method that may sometimes lead to counterintuitive appraisals, in that it discards all information about the distance between the raw values within a given context. By contrast, this information is partly preserved by using standardization, i.e., by transforming the absolute values in such a way that, within the s…

SOLAR MODELS WITH ACCRETION. I. APPLICATION TO THE SOLAR ABUNDANCE PROBLEM

2011

We generate new standard solar models using newly analyzed nuclear fusion cross sections and present results for helioseismic quantities and solar neutrino fluxes. We discuss the status of the solar abundance problem and investigate whether nonstandard solar models with accretion from the protoplanetary disk might alleviate the problem. We examine a broad range of possibilities, analyzing both metal-enriched and metal-depleted accretion models and exploring three scenarios for the timing of the accretion. Only partial solutions are found: one can bring either the depth of the convective zone or the surface helium abundance into agreement with helioseismic results, but not both simultaneousl…

Sensitivity Analysis of the MASLWR Helical Coil Steam Generator Using TRACE

2011

Accurate simulation of transient system behavior of a nuclear power plant is the goal of systems code calculations, and the evaluation of a code's calculation accuracy is accomplished by assessment and validation against appropriate system data. These system data may be developed either from a running system prototype or from a scaled model test facility, and characterize the thermal hydraulic phenomena during both steady state and transient conditions. The identification and characterization of the relevant thermal hydraulic phenomena, and the assessment and validation of thermal hydraulic systems codes, has been the objective of multiple international research programs. The validation and…

Dislocation mobility study of heavy ion induced track damage in LiF crystals

2008

Track damage created in LiF crystals by swift U, Kr, Xe and Ni ions with a specific energy of 11.1 MeV/u was studied using dislocation mobility measurements, track etching, SEM, AFM and optical microscopy. The results demonstrate continuity of etching of U tracks while discontinuities of etching are observed in the case of Xe ions. The relationship between the track structure and dislocation mobility in irradiated crystals is discussed. The dislocation mobility technique can serve as a highly sensitive method for track core damage studies.