Search results for "Costa"

Diluire Mondello Descrizioni per un progetto

2012

Il volume pubblica i materiali originali del concorso internazionale di idee per la riqualificazione urbana di Mondello, una localita balneare della costa settentrionale di Palermo. Concorso vinto dall'autore stesso. Il libro utilizza questa occasione di riflessione a partire da una occasione concreta di trasformazione, per affrontare criticamente le questioni scientifico disciplinari legate al tema del Landscape Urbanism e alle evoluzioni contemporanee della nozione di Progetto Urbano. Il volume ripercorre i contributi critici e teorici della disciplina degli ultimi vent'anni e propone un'avanzamento critico delle teorie sul paesaggio urbano e sulle geografie della città contemporanea. Il …

Detection of a synthetic sex steroid in the American crocodile (Crocodylus acutus): Evidence for a novel environmental androgen

2017

Endocrine-disrupting contaminants (EDC's) are well known to alter sexual differentiation among vertebrates via estrogenic effects during development, particularly in organisms characterized by temperature-dependent sex determination. However, substances producing androgenic effects typically lack potency when tested in laboratory settings and are virtually unstudied in field settings. Here, we assay levels of a synthetic androgen, 17a-methyltestosterone (MT), in a heavily male-biased population of American crocodiles in the Tempisque River Basin of Costa Rica based on the recent hypothesis that this chemical is an EDC in developing crocodilian embryos. The presence of MT was documented in a…

Diagnostic strategy in segmentation defect of the vertebrae: a retrospective study of 73 patients

2018

BackgroundSegmentation defects of the vertebrae (SDV) are non-specific features found in various syndromes. The molecular bases of SDV are not fully elucidated due to the wide range of phenotypes and classification issues. The genes involved are in the Notch signalling pathway, which is a key system in somitogenesis. Here we report on mutations identified in a diagnosis cohort of SDV. We focused on spondylocostal dysostosis (SCD) and the phenotype of these patients in order to establish a diagnostic strategy when confronted with SDV.Patients and methodsWe used DNA samples from a cohort of 73 patients and performed targeted sequencing of the five known SCD-causing genes (DLL3,MESP2,LFNG,HES7…

Blocking signaling through the gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to eto…

1999

BACKGROUND The mechanisms of drug resistance associated with advanced, hormone-independent prostate carcinoma are poorly understood. The human prostate carcinoma PC-3 cell line, derived from a metastatic tumor and lacking androgen receptors, represents a useful model to investigate drug resistance. METHODS The effects of oncostatin M (OM), antiinterleukin-6 (IL-6) treatment, or interference with the gp130-mediated signaling on etoposide- or cisplatin-mediated cytotoxicity were investigated. RESULTS Both endogenous and exogenous IL-6 and exogenous OM up-regulated cell growth and enhanced resistance of PC-3 tumor cells to both etoposide and cisplatin. The influence of IL-6 is controlled by tr…

The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma

2014

Interleukin (IL)-31A binds to an heterodimer composed of IL-31 receptor A (IL-31RA) and Oncostatin M Receptor (OSMR). The IL-31/IL-31R complex is involved in the pathogenesis of various skin diseases, including cutaneous T-cell lymphoma. No information is available on the relations between the IL-31/IL-31R complex and B-cell lymphoma. Here we have addressed this issue in follicular lymphoma (FL), a prototypic germinal center(GC)-derived B-cell malignancy. IL-31 enhanced primary FL cell proliferation through IL-31R-driven signal transducer and activator of transcription factor 1/3 (STAT1/3), extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation. In contrast, GC B cells d…

García Hurtado, Manuel Reyes (ed.): Soltando amarras: La costa noratlántica ibérica en la Edad Moderna

2021

Goigs de nostra Senyora de la Costa, en la Parroquial de la Vila de Cervera, pera sos devots

Corren variants amb diferents orles i petites variacions en l'ortografia, tamany de les lletres al tít., etc. El full orlat Grav. xil. enmarcat de la Mare de Déu, flanquejat per gerros amb flors Text del goig a tres col. separades per bandes

Goigs de nostra Senyora de la Costa, en la Parroquial de la Vila de Cervera, pera sos devots

Corren variants amb diferents orles i petites variacions en l'ortografia, tamany de les lletres al tít., etc. El full orlat Grav. xil. enmarcat de la Mare de Déu, flanquejat per gerros amb flors Text del goig a tres col. separades per bandes

Interleukin-6 and Soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis

1998

T HE INTERLEUKIN-6 (IL-6) family of cytokines acts via receptor complexes that contain at least one subunit of the signal transducing protein gp130.[1][1] The family comprises IL-6, IL-11, ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), leukemia inhibitory factor (LIF), and oncostatin M

A new genus and species of asteraceae-inhabiting aphid (hemiptera: aphididae) from Costa Rica and Mexico

2013

P. 323-331 Ucrimyzus villalobosi Mier Durante & Pérez Hidalgo gen. n., sp. n. (Hemiptera: Aphididae: Macrosiphini) are described from apterous and alate viviparous females collected on species of genera Bidens, Schkuhria, Senecio and Stevia (Asteraceae: Asteroideae) in Costa Rica and Mexico. Principal components analysis (PCA) was done to verify that the studied aphids belong to a single species regardless of their geographical origin or host plant. Molecular analyses were carried out on the sequences of a fragment of the mitochondrial gene encoding for cytochrome c oxidase subunit 1 (COI) and of a fragment of the nuclear gene encoding elongation factor 1α (EF1α). The taxonomic discussion t…