Search results for "Coste"
showing 10 items of 368 documents
Lung deposition of extrafine inhaled corticosteroid (ICS)-containing fixed combinations drug in COPD patients using Functional Respiratory Imaging (F…
2018
Introduction: FRI is a novel computational fluid dynamics (CFD)-based technique using formulation profile and patients lung CT scan to simulate aerosol deposition. Aims and objectives: To evaluate lung deposition of pressurized metered dose inhaler (pMDI) extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G Trimbow®) with pMDI extrafine BDP/FF (Foster®) pMDI and compared them with reference gamma scintigraphy data. Methods: FRI was used to assess, in silico, the deposition of pMDI combination products (BDP/FF/G and BDP/FF) in 20 moderate to severe COPD patients. FRI combined high-resolution lung CT scans of each patient with in silico computational flow simulati…
Novel inulin-based mucoadhesive micelles loaded with corticosteroids as potential transcorneal permeation enhancers
2017
In this work a new copolymer of inulin (INU) derivatized with ethylendiamine (EDA) and retinoic acid (RA), named INU-EDA-RA, was synthetized, characterized and employed to produce micelles as carriers for topical administration of corticosteroids for the potential treatment of diseases of posterior eye segment. Spectroscopic analysis confirmed a molar derivatization degree of 11.30 and 4.30% in EDA and RA, respectively. INU-EDA-RA micelles are capable of strong mucoadhesive interactions which result time-independent and stable over time but concentration depending. Moreover micelles are able to encapsulate efficiently from 3 to 13% (w/w) of lipophilic drugs, as dexamethasone, triamcinolone …
In situ delivery of corticosteroids for treatment of oral diseases.
2017
In many mucocutaneous disorders, corticosteroids therapy is currently central. Systemic therapy is restricted to severe disorders whereas topical applications are considered as the first-line treatment. The oral cavity environment, the medication form and other factors related to the delivery method are key factors for the therapy efficiency and effectiveness. Current marketed medications are not able to avoid wrong drug exposure and scarce patients’ compliance. Innovative in situ delivery systems are able to prolong the drug retention time on the mucosa and to avoid the drawbacks of conventional formulations. This review is intended to give a general overview of oral mucocutaneous patholo…
Use of ICS/LABA (extra-fine and non-extra-fine) in elderly asthmatics.
2016
Age represents an exclusion criterion in randomized clinical trials designed to test the efficacy and safety of inhaled drugs in asthma. As a consequence, data on efficacy and safety of inhaled corticosteroid (ICS) and long-acting β2 agonist (LABA) combinations in elderly asthmatics are scanty. Older age is associated with an increased proportion of comorbid conditions; in addition, all organ functions undergo a process of senescence, thus reducing their ability to metabolize the agents. Overall, these age-associated conditions may variably, and often unpredictably, affect the metabolism and excretion of respiratory drugs. However, pharmacological treatment of asthma does not follow specifi…
La factibilidad de los derechos sociales en Europa: debate actual y perspectivas
2021
El presente trabajo reflexiona acerca de la relación entre el análisis económico y la efectividad y justiciabilidad de los derechos sociales en Europa. En efecto, si en la era de la globalización se confiere una posición relevante al mercado cuando se redactan las normas nacionales e internacionales sobre derechos sociales (incluso en la fase inicial –previendo el impacto económico de dichas normas, la denominada “factibilidad”), el autor pone de relieve que la estructura jurídica y dogmática de tales derechos sociales es tan idónea como la de los derechos civiles a la hora de garantizar su justiciabilidad. En tal sentido, se subraya el camino hacia un estándar común europeo en materia de d…
The determinants of net interest income in the Mexican banking system: An integrated model
2009
This paper analyzes net interest income in the Mexican banking system over the period 1993-2005. Taking as reference the seminal work by Ho and Saunders (1981) and subsequent extensions by other authors, our study models the net interest margin simultaneously including operating costs and diversification and specialization as determinants of the margin. The results referring to the Mexican case show that its high margins can be explained mainly by average operating costs and by market power. Although non-interest income has increased in recent years, its economic impact is low. El trabajo analiza el margen de intermediación de la banca Mexicana en el periodo 1996-2005. Tomando como referenc…
Behavioural Consequences of P-Glycoprotein Deficiency in Mice, with Special Focus on Stress-Related Mechanisms
2012
P-glycoprotein (P-gp), an efflux transporter localised in the blood-brain barrier, limits the access of multiple xenobiotics to the central nervous system. Whether it is also implemented in the transport of the endogenous glucocorticoid corticosterone is a matter of debate. The P-gp knockout mouse model [abcb1a/b (-/-)] has been shown to differ in the functioning of the hypothalamic-pituitary adrenal (HPA) axis. In the present study, we investigated the behaviour of abcb1a/b (-/-) and wild-type mice with respect to stress-related tests and the effects of corticosterone. Behavioural activities were assessed in the open field (OF) test for 4 days, and in the forced swimming test (FST) and tai…
Análisis de los factores de éxito en el proceso de creación de empresas. Impacto en la supervivencia y en su capacidad de innovación
2017
El emprendimiento ha sido ampliamente estudiado. Al principio, el emprendedor fue tratado por la literatura como comerciante, actualmente el emprendedor se percibe desde la literatura como un agente innovador y de cambio. Esta perspectiva del emprendedor es la que se ha tenido en cuenta en esta tesis. La tesis se compone de tres estudios, los objetivos de los cuales son dos, por una parte determinar qué factores institucionales y económicos tienen una influencia en la creación de las empresas y por otra parte analizar cómo afecta el entorno, así como las características del emprendedor y la empresa a la supervivencia de la misma en el corto y medio plazo. Los resultados muestran que el nive…
Estimación de la mortalidad atribuible a enfermedades laborales en España, 2004
2007
Ana M. García García (anagar@uv.es) El registro de enfermedades profesionales en España resulta insuficiente para valorar el impacto de las enfermedades de origen laboral en nuestro país. En el presente estudio se estima la mortalidad por enfermedades laborales y sus costes en base a riesgos atribuibles estimados en la literatura internacional.Métodos: Se aplican estimaciones de riesgo atribuible para la mortalidad de origen laboral calculadas por Nurminen y Karjalainen (Finlandia, 2001) al total de muertes por las enfermedades y grupos de edad relevantes en España y por comunidades autónomas en 2004. Se calculan los años potenciales de vida y de vida laboral perdidos. A partir de estos últ…
Compensatory education: Long-term effects of early parental implication (and III: The C.P.C.)
2007
After describing the program of early compensatory education (from age 3 to 9), called Chicago Child-Parent Centers (CPC), this article collects and analyses the evaluation studies of that Program from a longitudinal perspective – Chicago Longitudinal Study (CLS)-, focusing primarily on methodological problems and afterwards on the short and, mainly, long terms effects, until the targeted subjects of the Program reached the age of 24. The studies confirm the Program has lasting educational (higher performance and educational achievements) and social (higher social adjustment) effects. Subsequently, it analyses which elements of the Program can produce these beneficial effects, which are bas…