Search results for "Covid19"
showing 10 items of 38 documents
SARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecula…
2020
Background: The occurrence of trans-placental transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection remains highly debated. Placental positivity for SARS-CoV-2 has been reported in selected cases, but infection or virus-associated disease of fetal tissues or newborns remains to be demonstrated. Methods: We screened for SARS-CoV-2 spike (S) protein expression placentas from 101 women who delivered between February 7 and May 15 2020, including 15 tested positive for SARS-CoV-2 RNA, 34 tested negative, and 52 not evaluated as they did not meet testing criteria (32), or delivered before COVID-19 pandemic declaration (20). Immunostain for SARS-CoV-2 nucleocapsid…
Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research.
2020
AbstractCoronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The suspected contribution of thrombotic events to morbidity and mortality in COVID-19 patients has prompted a search for novel potential options for preventing COVID-19-associated thrombotic disease. In this article by the Global COVID-19 Thrombosis Collaborative Group, we describe novel dosing approaches for commonly used antithrombotic agents (especially heparin-based regimens) and the potential use of less widely used antithrombotic drugs in the absence of confirmed thrombosis. Although these therapies may have direct…
Smart and resilient manufacturing in the wake of COVID-19.
2021
Since 2020, manufacturers have been facing unprecedented and extraordinary challenges with the COVID-19 outbreak, which severely disrupted manufacturing operations around the world. Some manufac- turers have shifted gears to help address dire shortages during the coronavirus pandemic. Others were thrown into deep unknowns and faced with the grim prospect of being closed down. We have seen a sprawling network of multinationals and local businesses step in to fill a void by using 3D printers to make personal protective equipment (PPE) such as face shields, respirator masks, nasal swabs and even ventilator parts. Large manufacturers attempted to rejig parts of their production lines to mass-pr…
Management of liver disease in Italy after one year of the SARS-CoV-2 pandemic: a web-based survey
2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)pandemic has severely limited the clinical activity of most hospitals around the world. A previous survey of the Italian Association for the Study of the Liver (AISF) has demonstrated a negative impact of the first pandemic wave on all inpatient and outpatient hepatologyactivities. Like other countries, Italy has subsequently experienced a second and third wave, which occurred in November 2020 and in March 2021 respectively. During the second and third wave many hospitals had already developed emergency management plans and improved knowledge on the management of mild-moderate COVID19 disease was available. However, it is unknown w…
The pandemic within the pandemic: the surge of neuropsychological disorders in Italian children during the COVID-19 era
2022
Abstract Background Quarantine and isolation measures during COVID-19 pandemic may have caused additional stress and challenged the mental health of the youth. Aim of the study is to investigate the COVID-19 pandemic impact on neuropsychological disorders (NPD) of Italian children and adolescents to provide general pediatric recommendations. Material and methods A retrospective multicenter observational study was planned by the Italian Pediatric Society (SIP) to explore the impact of COVID-19 on the access of children to pediatric Emergency Departments (pED) for the evaluation of neuropsychological symptoms, collecting the classification codes of diagnoses between March 1, 2019 and March 2,…
Machine learning classification for COVID19 patients performed on small datasets of CT scans.
2022
In this work we evaluated the possibility of carrying out classifications of the outcome of patients with COVID19 disease through machine learning (ML) techniques working on small datasets of computed tomography (CT) images. In fact, one of the most common problems for medical artificial intelligence (AI) applications is the limited availability of annotated clinical data for model training. In the framework of the artificial intelligence in medicine (AIM) project funded by INFN, we analyzed datasets of CT scans of 79 subjects combined with clinical data containing information relating to positive outcome (no need for intensive care) or poor prognosis (admission into intensive care unit and…
Anemia as a risk factor for disease progression in patients admitted for COVID-19: data from a large, multicenter cohort study
2023
: In respiratory infections, anemia is both a consequence of acute inflammation and a predictor of poor clinical outcomes. There are few studies investigating the role of anemia in COVID-19, suggesting a potential role in predicting disease severity. In this study, we aimed to assess the association between the presence of anemia at admission and incidence of severe disease and death in patients hospitalized for COVID-19. Data from all adult patients admitted for COVID-19 in University Hospital "P. Giaccone" Palermo, and University Hospital of Bari, Italy, were retrospectively collected from 1st of September 2020 to 31 August 2022. The association between anemia (defined as Hb < 13 g/dl …
COVID-19 and Pregnancy: Have We Gotten through the Darkest Hour?
2022
On December 2019, a new Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) was isolated and identified in Wuhan (China) [...]
Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection
2021
WOS:000613461600006 PubMed ID: 32926494 Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity…
Un mese di Covid-19 in Italia: una guida alla lettura dei dati per bloccare la disinformazione
2020
e dal primo deceduto a Padova, siamo nel bel mezzo di un sovraccarico di informazioni sul nuovo Coronavirus, con aggiornamenti continui dei casi e flussi infiniti di informazioni. E se tante sono le informazioni che ci arrivano, altrettante sono le domande nuove che ogni giorno ci poniamo. Tra queste, quella che riempe le nostre lunghe giornate in cui vediamo la nostra liberta sempre pi ` u` decurtata da normative sempre piu stringenti, e relativa ` alla temporaneita di queste soluzioni: Quanto durer ` a il ` “temporaneo”? Ci sono stati proposti i piu svariati grafici, ` alcuni semplici altri piu complessi; abbiamo sentito parlare ` di andamento esponenziale, logaritmico, di picco e talvolt…