6533b827fe1ef96bd1285dc7
RESEARCH PRODUCT
Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection
Di Mascio DanieleSaccone GabrieleSen Cihat Daniele Di MascioGalindo AlbertoGrünebaum AmosYoshimatsu JunStanojevic MilanKurjak AsımChervenak Frank María José Rodríguez Suárez Zita Maria Gambacorti-passerini María De Los Angeles Anaya Baz Esther Vanessa Aguilar Galán Yolanda Cuñarro López Juan Antonio De León Luis Ignacio Cueto HernándezHerraiz IgnacioVillalain CeciliaVenturella RobertaGiuseppe Davide RizzoMappa IleniaGerosolima GiovanniHellmeyer LarsKönigbauer JosefineAmeli GiadaFrusca TizianaVolpe Nicola Giovanni Battista Luca ScheraFieni StefaniaEsposito EutaliaSimonazzi Giuliana Gaetana Di DonnaYoussef Aly Anna Nunzia Della Gatta Mariano Catello Di DonnaChiantera VitoBuono NatalinaSozzi GiulioGreco PantaleoMorano DanilaBianchi Beatrice Maria Giulia Lombana MarinoLaraud FedericaRamone AriannaCagnacci AngeloBarra FabioGustavino ClaudioSimone FerreroGhezzi FabioCromi AntonellaAntonio Simone Laganà Valentina Laurita LongoStollagli FrancescaSirico AngeloLanzone AntonioDriul LorenzaCecchini FabianaXodo SerenaRodriguez BrianMercado-olivares FelipeElkafrawi DeenaSisti GiovanniEsposito RosannaCoviello AntonioCerbone MarcoMorlando MaddalenaSchiattarella AntonioColacurci Nicola Pasquale De FranciscisCataneo IlariaLenzi MarinellaSandri FabrizioBuscemi RiccardoGattei Giorgia Francesca Della SalaValori Eleonora Maria Cristina RovellottiDone ElisaFaron GillesGucciardo LeonardoValentina EspositoVena FlaminiaGiancotti AntonellaBrunelli RobertoMuzii LudovicoNappi LuigiSorrentino FeliceLiberati MarcoBuca DaniloLeombroni Martina Francesca Di SebastianoFranchi Massimo Quintino Cesare IannicielloGarzon SimonePetriglia GiulianoBorrello Leonardo Albaro Josè Nieto-calvache Juan Manuel Burgos-lunaKadji CarolineCarlin AndrewBevilacqua ElisaMoucho MarinaViana PedroFigueiredo Rita José Morales RosellóLoscalzo GabrielaMartinez-varea AliciaDiago VincenteS Jimenez Lopez Jesús Alicia Yeliz AykanatStefano Domenico CosmaAndrea Roberto CarossoChiara BenedettoBermejo Amanda Otto Henrique May FeuerschuetteUyaniklar Ozlem Sakine Rahimli OcakougluAtak ZelihaGündüz Reyhan Esra Tustas HaberalFroessler BerndParange AnupamPalm PeterSamardjiski IgorTaccaliti ChiaraOkuyan ErhanDaskalakis George Renato Augusto Moreira De SaPittaro Alejandro Maria Luisa Gonzalez-duran Ana Concheiro Guisan ŞErife ÖZlem GençZlatohlávková Blanka Anna Luengo Piqueras Dolores Esteban Oliva Aylin Pelin CilApi OlusAntsaklis PanosPles LianaKyvernitakis IoannisMaul HolgerMalan MarcelLila AlbertGranese RobertaErcoli AlfredoZoccali GiuseppeAndrea VillascoNicoletta BigliaMadalina CiuhodaruElena CostaDaelemans CarolinePintiaux Axelle Elif Gül Yapar EyiCueto ElisaHadar EranDollinger SarahA Brzezinski-sinai NoaHuertas ErasmoArango PedroSanchez Amadeo Javier Alfonso SchvartzmanCojocaru LiviuTuran SifaTuran Ozhan Maria Carmela Di Dedda Rebeca Garrote MolpeceresZdjelar SnezanaPremru-srsen TanjaKornhauser-cerar LilijanaDruškovič Mirjam Valentina De RobertisStefanovic VedranNupponen IrmeliNelskylä KaisaKhodjaeva ZulfiyaA Gorina KseniaT Sukhikh Gennady Giuseppe Maria MaruottiVisentin SilviaCosmi ErichFerrari JacopoGatti AlessandraLuvero DanielaAngioli RobertoPuri LudovicaPalumbo MarcoD'urso GiusellaColaleo Francesco Agnese Maria Chiara Rapisarda Ilma Floriana CarboneLamberto ManzoliMaria Elena FlaccoNazzaro GiovanniLocci MariavittoriaGuida Maurizio Attilio Di Spiezio Sardo Pierluigi Benedetti PaniciKhalil AsmaBerghella VincenzoBifulco GiuseppeScambia GiovanniZullo FulvioD'antonio Francescosubject
COVID19medicine.medical_treatmentcoronavirus; COVID-19; infection; pregnancy; SARS-CoV-2Abortioninfectious diseaseslaw.inventionCohort Studies0302 clinical medicinelaw3123 Gynaecology and paediatricsPregnancyObstetrics and Gynaecology030212 general & internal medicinePregnancy Complications Infectious030219 obstetrics & reproductive medicineRadiological and Ultrasound TechnologyTransmission (medicine)ObstetricsPregnancy OutcomeObstetrics and GynecologyCOVID19; Coronavirus; SARS-COV-2; infection; pregnancy.General MedicineDisease 2019 Covid-19Intensive care unit3. Good healthHospitalizationIntensive Care UnitsMaternal MortalitySettore MED/40Radiology Nuclear Medicine and imagingGestationFemalepregnancycoronavirus Pandemics Pregnancy Pregnancy Complications Infectious Pregnancy Outcome Respiration Artificial Retrospective Studies SARS-CoV-2 COVID-19 Infant Newborn Intensive Care UnitsMaternal MortalityInfectionCohort studyAdultmedicine.medical_specialtyCOVID-19; SARS-CoV-2; coronavirus; infection; pregnancyNO03 medical and health sciencesmedicineHumansRadiology Nuclear Medicine and imagingPandemicsRetrospective StudiesMechanical ventilationPregnancybusiness.industrySARS-CoV-2Infant NewbornInfantCOVID-19Retrospective cohort studymedicine.diseaseRespiration ArtificialinfectionCoronaviruscoronaviruReproductive MedicinebusinessCOVID19; Coronavirus; SARS-COV-2; infection; pregnancydescription
WOS:000613461600006 PubMed ID: 32926494 Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251(27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. (C) 2020 International Society of Ultrasound in Obstetrics and Gynecology.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-01 |