Search results for "Creative commons"
showing 8 items of 28 documents
MicroRNAs in Colorectal Cancer Drug Resistance: Shooters become Targets
2013
Copyright: © 2013 Fanale D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. MicroRNAs (MiRNAs) are involved in the regulation of several biological processes such as development, differentiation, metabolism, apoptosis and proliferation. Recently, it has been shown that deregulated expression of miRNAs are present in different human cancers, suggesting a potential role in carcinogenesis [1,2]. Recent evidence suggests that miRNAs may represent potential new therapeutic approaches in patients with dru…
The Effect of Different High-Intensity Periodization Models on Endurance Adaptations
2016
Purpose: This study aimed to compare the effects of three different high-intensity training (HIT) models, balanced for total load but differing in training plan progression, on endurance adaptations. Methods: Sixty-three cyclists (peak oxygen uptake (V˙O2peak) 61.3 ± 5.8 mL·kg−1·min−1) were randomized to three training groups and instructed to follow a 12-wk training program consisting of 24 interval sessions, a high volume of low-intensity training, and laboratory testing. The increasing HIT group (n = 23) performed interval training as 4 × 16 min in weeks 1–4, 4 × 8 min in weeks 5–8, and 4 × 4 min in weeks 9–12. The decreasing HIT group (n = 20) performed interval sessions in the opposite…
Traditional Medicine with Plants Present and Past
2014
Copyright: © 2014 Efferth T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Traditional Medicine with Plants – Present and Past Thomas Efferth1* and Henry Johannes Greten2,3 1Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany 2Abel Salazar Biomedical Sciences Institute, University of Porto, Portugal 3Heidelberg School of Chinese Medicine, Heidelberg, Germany
The Microbiome Studies in Metabolic Diseases have Advanced but are Poorly Standardized and Lack a Mechanistic Perspective
2015
Copyright: © 2014 Pekkala S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. During the last decades hundreds of studies have reported the association of Gut Microbiota (GM) with obesity and related metabolic disorders [1]. However, recently the microbiome studies were criticized about the lack of skepticism [2]. The author of the article questioned the role of GM in different diseases and asked whether the detected differences between the subjects biologically matter? We do believe that the role of…
Smart city dvelopment with digital twin technology
2020
Growing urban areas are major consumers of natural resources, energy and raw materials. Understanding cities´ urban metabolism is salient when developing sustainable and resilient cities. This paper addresses concepts of smart city and digital twin technology as means to foster more sustainable urban development. Smart city has globally been well adopted concept in urban development. With smart city development cities aim to optimize overall performance of the city, its infrastructures, processes and services, but also to improve socio-economic wellbeing. Dynamic digital twins are constituted to form real-time connectivity between virtual and physical objects. Digital twin combines virtual …
Coupling Proteomics and Fermentation Technology for the Improvement of Bioactive Molecule Production Yield in Actinomycetes
2013
Copyright: © 2013 Gallo. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Most bioactive molecules (like anticancers, antitumors, antibiotics, immunosuppressants, insecticidals, antivirals, herbicidals, antifungals) with valuable industrial and market value are naturally produced by actinomycetes [1-4], Gram-positive filamentous bacteria widespread in both terrestrial and aquatic environments [5,6]. Out of thousands of bioactive molecules, also known as secondary metabolites since they are not essential for…
Superwomen? Young sporting women, temporality and learning not to be perfect
2020
New forms of neoliberal femininity create demanding horizons of expectation for young women. For talented athletes, these pressures are intensified by the establishment of dual-career discourses that construct the combination of high-performance sport and education as a normative, ‘ideal’ pathway. The pressed time perspective inherent in dual-careers requires athletes to employ a variety of time-related skills, especially for young women who aim to live up to ‘superwoman’ ideals that valorise ‘success’ in all walks of life. Drawing on existential phenomenology, and in-depth interviews with 10 talented Finnish sportswomen (aged 19–22), we explored their experiences of lived time when pursui…
Open Source and New Media Artists
2007
This paper deals with the open source method practiced within the new media art context. I present a case study on an international festival, PixelACHE 2005, which was organized by and for new media artists and served as a platform for demonstrations of new media projects and as a meeting place for experimental new media artists. In this article I discuss how new media artists adapted the open source ideology. Open source is seen both as a more liberal method of distribution and as an open joint creative process. I was particularly interested in what kind of motives the new media artists had for taking part in the PixelACHE festival and the joint artistic creative process. In my analysis, I…