Search results for "Creta"

Stratigraphy and stage boundaries in reference sections of the Upper Cretaceous Chalk in the east of the Paris Basin: the “Craie 700” Provins borehol…

2005

Abstract The Provins boreholes (Poigny: Craie 701, and Sainte-Colombe: Craie 702) drilled in 1999 as part of the “Craie 700” project initiated by the Paris Basin Geologists' Association provide reference sections for the Upper Cretaceous of the eastern part of the Paris Basin. The lithology of the Cretaceous drilled at Poigny and Sainte-Colombe is presented in two logs displaying major litho-events that provide lines of correlation. Bio-events are expressed by the appearance/disappearance of index species of fossils. Foraminifera give a biozonation close to that defined by previous work on the Anglo-Paris Basin. Some of these bio-events provide a second set of lines useful for correlation. …

Cretaceous stratigraphic scales based on benthic Foraminifera in West European basins (biochronohorizons)

1995

Agreement on the Choice of Non-applicable Law or Law not in Accordance with Article 22(1) of the Twin Regulations: what Consequences for the Couple’s…

2021

Los Reglamentos (UE) 2016/1103 y 2016/1104 del Consejo autorizan a las parejas transfronterizas a elegir la ley aplicable a sus relaciones patrimoniales sobre la base de uno de los criterios enumerados en el artículo 22.1. Sin embargo, el acuerdo de elección de la ley puede tener un contenido diferente al señalado en la redacción del artículo 22 de los ?Reglamentos Gemelos?. El objetivo del análisis es ilustrar que sería incorrecto sostener que tales acuerdos son, a priori, inválidos o no permiten la autonomía de la voluntad. Esta cuestión requiere una evaluación de la finalidad concreta del acuerdo de las partes y debería, al menos, estar abierta al examen del tribunal competente.

The sunset of Gortyn: amphorae in 7th –8th centuries AD

2014

Gortyn (A. Di Vita [ed.] 2000-01), some new contexts, more delimited and reliable, allow us to define better circulation, developments, and local use of amphorae in the last periods of urban life of the Cretan city. Two contexts of the mid-late 7th and late 7th-8th centuries are briefly analysed, coming from different quarters of the town (the Old Agora and the Early Byzantine houses near the “Praetorium”), and resulting from different formative processes, which could represent the circulation trends just before, and in the re-occupation phase after the earthquake that dismembered the Late Roman urban layout at the end of the 7th/early 8th century. They display a variety of imports from tra…

A new giant ground bird from the Upper Cretaceous of southern France

1998

New discoveries afford a much better knowledge of the large birds previously reported from the Upper Cretaceous of southern France on the basis of a single synsacrum fragment. An incomplete pelvis consisting of the synsacrum with part of the ilia is used to define a new taxon of bird, Gargantuavis philoinos , to which a femur is also referred. This bird is characterized by its very large size (comparable to that of an ostrich), a broad pelvis with an anteriorly placed acetabulum, and a short robust femur. The occurrence of this very large, flightless, bird in the Late Cretaceous shows that, contrary to widespread opinion, the evolution of large terrestrial birds was not simply the result of…

Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds.

2006

The amyloid-beta (Abeta) peptides and specifically the highly amyloidogenic isoform Abeta42 appear to be key agents in the pathogenesis of familial and sporadic forms of Alzheimer's disease (AD). The final step in the generation of Abeta from the amyloid precursor protein is catalyzed by the multiprotein complex gamma-secretase, which constitutes a prime drug target for prevention and therapy of the disease. However, highly potent gamma-secretase inhibitors that block formation of all Abeta peptides have provoked troubling side effects in preclinical animal models of AD. This toxicity can be readily explained by the promiscuous substrate specificity of gamma-secretase and its essential role…

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

2004

Alzheimer disease (AD) is characterized by excessive deposition of amyloid beta-peptides (A beta peptides) in the brain. In the nonamyloidogenic pathway, the amyloid precursor protein (APP) is cleaved by the alpha-secretase within the A beta peptide sequence. Proteinases of the ADAM family (adisintegrin and metalloproteinase) are the main candidates as physiologically relevant alpha-secretases, but early lethality of knockout animals prevented a detailed analysis in neuronal cells. To overcome this restriction, we have generated transgenic mice that overexpress either ADAM10 or a catalytically inactive ADAM10 mutant. In this report we show that a moderate neuronal overexpression of ADAM10 i…

Over-expression of two different forms of the α-secretase ADAM10 affects learning and memory in mice

2006

Members of the ADAM family (adisintegrin and metalloprotease) are the main candidates for physiologically relevant alpha-secretases. The alpha-secretase cleaves in the non-amyloidogenic pathway the amyloid precursor protein within the region of the Abeta peptides preventing their aggregation in the brain. The increase of alpha-secretase activity in the brain provides a plausible strategy to prevent Abeta formation. Concerning this possibility two transgenic mouse lines (FVB/N) have been created: mice over-expressing the bovine form of the alpha-secretase (ADAM10) and mice over-expressing an inactive form of the alpha-secretase (ADAM10-E348A-HA; ADAM10-dn). For behavioral examination a F1 ge…

Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.

2008

A disintegrin and metalloprotease (ADAM) 10 is the main candidate enzyme for the alpha-secretase processing of the amyloid precursor protein (APP). Neuron-specific ADAM10 overexpression proved beneficial in the APP[V717I] mutant Alzheimer mouse model [Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz F (2004) A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J Clin Invest 113:1456-1464]. Since Alzheimer patients have a high prevalence for epileptic seizures, we investigated the effects of ADAM10 modula…

Weathering Products of a Dismantled Variscan Basement. Minero-Chemical Proxies to Insight on Cretaceous Palaeogeography and Late Neogene Palaeoclimat…

2020

This study compares, for the first time, the mineralogy and geochemistry of two residual-clay deposits in NW Sardinia (Nurra district) that formed at different times in tropical and sub-tropical climates. Both deposits represent palaeosols with deep-weathered residual profiles and overlie Mesozoic carbonate rocks that were deposited on the south European palaeomargin. The older alterite is Cenomanian–Turonian in age and grades upward into a horizon of karstic bauxite, whereas the younger unit occurs within alluvial deposits of Late Neogene age. The Cretaceous palaeosol represents the precursor of the overlying bauxite and formed from unknown sedimentary parent rocks. In contrast, the Messin…