Search results for "Cripto"
showing 10 items of 863 documents
The shell-forming proteome of Lottia gigantea reveals both deep conservations and lineage-specific novelties
2013
19 pages; International audience; Proteins that are occluded within the molluscan shell, the so-called shell matrix proteins (SMPs), are an assemblage of biomolecules attractive to study for several reasons. They increase the fracture resistance of the shell by several orders of magnitude, determine the polymorph of CaCO(3) deposited, and regulate crystal nucleation, growth initiation and termination. In addition, they are thought to control the shell microstructures. Understanding how these proteins have evolved is also likely to provide deep insight into events that supported the diversification and expansion of metazoan life during the Cambrian radiation 543 million years ago. Here, we p…
New Error Measures to Evaluate Features on Three-Dimensional Scenes
2011
In this paper new error measures to evaluate image features in three-dimensional scenes are proposed and reviewed. The proposed error measures are designed to take into account feature shapes, and ground truth data can be easily estimated. As other approaches, they are not error-free and a quantitative evaluation is given according to the number of wrong matches and mismatches in order to assess their validity
Contemporary genetic technologies and female reproduction
2012
Background The Fifth Evian Annual Reproduction (EVAR) Workshop Meeting discussed knowledge regarding contemporary genetics in female reproduction. Methods Specialist reproductive medicine clinicians and geneticists delivered presentations based on published literature and current research. The content of this report is based on the expert presentations and subsequent group discussions that took place during this Workshop. Results Numerous ovarian genes with a role in infertility have been identified. Future challenges for genetic screening of patients, such as those with polycystic ovary syndrome, primary ovarian insufficiency or endometriosis, include the identification of high-throughput …
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines
2014
Cancer cell lines are a tremendous resource for cancer biology and therapy development. These multipurpose tools are commonly used to examine the genetic origin of cancers, to identify potential novel tumor targets, such as tumor antigens for vaccine devel-opment, and utilized to screen potential therapies in preclinical studies. Mutations, gene expression, and drug sensitivity have been determined for many cell lines using next-generation sequencing (NGS). However, the human leukocyte antigen (HLA) type and HLA expression of tumor cell lines, characterizations necessary for the development of cancer vaccines, have remained largely incomplete and, such information, when available, has been …
Principal Component Analysis on molecular descriptors as alternative point of view in the search of new Hsp90 inhibitors
2008
Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium.
2021
Abstract STUDY QUESTION Are SARS-CoV-2 canonical cell entry machinery, consisting of ACE2, TMPRSS2, NRP1 and LY6E, or alternative potential cell entry machinery, consisting of BSG, ANPEP, CD209, CLEC4G, TMPRSS4, TMPRSS11A, FURIN, CTSB, CTSL and IFITM1, expressed in the human endometrium across the menstrual cycle? SUMMARY ANSWER Analysis of cell entry factors for SARS-CoV-2 by single-cell RNA-sequencing (scRNAseq) in the preconceptional human endometrium reveals low risk of infection. WHAT IS KNOWN ALREADY Gene expression datasets from bulk endometrial tissue show no significant expression of the SARS-CoV-2 receptor ACE2 and TMPRSS2. This is in contrast to reported expression of ACE2 at the…
’-omics’ technology and human reproduction: reproductomics
2012
The success of assisted reproduction technology is highly dependent on a precise selection of gametes and embryos and determining the best endometrial window for embryo implantation. For many years, morphological criteria have constituted the only way to assess spermatozoon, oocytes, embryos and endometrial samples in order to improve outcomes. However, this approach has reached a ceiling of success and has been related to unacceptably high rates of multiple pregnancies. New technologies have been developed in order to improve the results and reduce risks via better selection of those gametes and embryos with the highest pregnancy potential, and of more favorable endometrial environments fo…
Parathënie
2020
Prefazione al volume "Mirdita në Arkivin e Propagandës Fide në shekujt XVII-XIX" contenente una raccolta di documenti storici - trascritti e tradotti in albanese da Arben Ndreca - sulla regione di Mirdita nell'Albania settentrionale, i cui originali sono conservati presso l'Archivio Storico di Propaganda Fide in Vaticano. Si tratta principalmente di relazioni che i prelati della Chiesa Cattolica in Albania inviavano periodicamente alla Congregazione di Propaganda Fide durante un periodo di oltre tre secoli (prima metà XVII sec. - fine XIX sec.) e che oggi costituiscono una preziosa fonte di dati per la storia di quella regione. Preface to the volume "Mirdita në Arkivin e Propagandës Fide në…
«Fue levado mi entendimiento»: Teresa de Cartagena y la escritura mística en femenino
2016
Resumen: En torno a los anos 1470-1475, la religiosa Teresa de Cartagena (sobrina del prestigioso humanista Alonso de Cartagena) deseo y necesito escribir sobre su personal experiencia en femenino del amor divino, y nos lego dos valiosos tratados que abren la senda de los diversos textos compuestos por religiosas castellanas del siglo XVI. La escritora burgalesa destaca meritoriamente en la historia de la literatura bajomedieval y puede considerarse una digna precedente de la gran escritora Teresa de Jesus. Ambas comparten ciertas similitudes biograficas y espirituales que merecen tenerse en cuenta a la hora de disenar una genealogia de autoras de literatura espiritual en lengua castellana.…
Indización y uso de los Descriptores MeSH en Hospitalización a Domicilio
2017
Objetivo: Analizar la utilización de los Descriptores, como Major Topic, en la indización de los artículos sobre Hospitalización Domiciliaria en la base de datos MEDLINE.Método: Estudio descriptivo transversal de los registros de indización recogidos en la base de datos MEDLINE (vía PubMed) hasta 2016. El término utilizado, como descriptor principal para la búsqueda fue «Home Care Services, Hospital-Based».El método de muestreo fue la aleatorización simple sin reemplazo, tomando como base el número total de referencias obtenidas (tamaño muestral 386).Resultados: Se observaron diferencias significativas en la utilización de los Descriptores asociados a hospitalización a domicilio. La compara…