Search results for "Critical"
showing 10 items of 3024 documents
Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites
2022
AbstractAmyloid protein aggregates are not only associated with neurodegenerative diseases and may also occur as unwanted by-products in protein-based therapeutics. Surfactants are often employed to stabilize protein formulations and reduce the risk of aggregation. However, surfactants alter protein-protein interactions and may thus modulate the physicochemical characteristics of any aggregates formed. Human insulin aggregation was induced at low pH in the presence of varying concentrations of the surfactant polysorbate 80. Various spectroscopic and imaging methods were used to study the aggregation kinetics, as well as structure and morphology of the formed aggregates. Molecular dynamics s…
Alla ricerca dei fattori rilevanti nell’adozione dei sistemi di gestione della performance nelle amministrazioni pubbliche territoriali. L’analisi di…
2013
La ricerca scientifica ha dimostrato che la gestione della performance nelle amministrazioni pubbliche sta oggi spostando il proprio focus dalla mera attività di raccolta e rendicontazione di dati alla generazione di informazioni atte a supportare la formulazione di decisioni. L’analisi comparativa dei casi di studio analizzati in questo articolo mira ad identificare i fattori critici sottostanti alla progettazione e all’utilizzo dei sistemi di gestione della performance nelle amministrazioni regionali. Da questa analisi emerge che alcune variabili risultano essenziali ai fini di un’efficace adozione dei sistemi di performance management. Tra queste variabili sono annoverabili: il ruolo del…
Sub- and supercritical fluid extraction of trichloropyridinol from soil prior to immunoassay
1997
A comparative study on the extraction of TCP (3,5,6-trichloro-2-pyridinol, a metabolite of chlorpyrifos) from soil with CO2 and H2O is reported. The polarity of the analyte requires the presence of both a cosolvent (methanol) and an ion-pair reagent [(1R)-(-)-10-camphorsulfonic acid ammonium salt] for 95% extraction in 30 min when supercritical CO2 at 40 degrees C and 383 bar is used as extractant. Subcritical water (250 degrees C and 200 bar) enables complete extraction within 15 min without additives. Quantitation of the target analyte is performed by specific immunoassay using a non-commercial monoclonal antibody which provides a linear determination range between 0.005 and 5 micrograms/…
The Navier–Stokes equations in exterior Lipschitz domains: L -theory
2020
Abstract We show that the Stokes operator defined on L σ p ( Ω ) for an exterior Lipschitz domain Ω ⊂ R n ( n ≥ 3 ) admits maximal regularity provided that p satisfies | 1 / p − 1 / 2 | 1 / ( 2 n ) + e for some e > 0 . In particular, we prove that the negative of the Stokes operator generates a bounded analytic semigroup on L σ p ( Ω ) for such p. In addition, L p - L q -mapping properties of the Stokes semigroup and its gradient with optimal decay estimates are obtained. This enables us to prove the existence of mild solutions to the Navier–Stokes equations in the critical space L ∞ ( 0 , T ; L σ 3 ( Ω ) ) (locally in time and globally in time for small initial data).
Photocatalytic degradation of carbaryl in aqueous TiO2 suspensions containing surfactants
1999
The effect of ionic and non-ionic aliphatic surfactants on the photocatalytic degradation of Carbaryl (1-naphtyl-N-methylcarbamate) in aqueous solutions containing suspended TiO2 (anatase) particles, under irradiation with simulated AM1 solar light, was investigated. A neat inhibitory effect on the degradation rate was observed, depending on the nature of the surfactant and on the initial pH of the solution. The decay profiles of the primary process corresponded to the usual pseudo-first order kinetics for surfactant concentrations below the critical micellar concentration range, whereas a more complicate behaviour was observed in the presence of micellar aggregates. Mineralization of the p…
Hydrothermal synthesis of nanostructured inorganic powders by a continuous process under supercritical conditions
2005
Abstract In this study, using a prototype of hydrothermal synthesis in subcritical and supercritical water working in a continuous way, nanometric ceramic precursors with perfectly defined composition are produced: spinel ferrites such as Fe2CoO4, TiO2 with anatase structure and also perovskite structures such as BaZrO3. The as-prepared powders are fully characterized by complementary experiments: X-ray diffraction, electron microscopies, EDX spectrometry, surface area measurement, etc. Thus, particles size, morphology, aggregation state, crystal structure, composition are investigated. Moreover, magnetic properties of the ferrites products are studied. The powders obtained are pure phases …
Anesthetic management of a patient diagnosed with CADASIL (cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopat…
2011
CADASIL (cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leu-koencephalopathy) is an infrequent inherited disease that could have anesthetic implica-tions. However these have rarely been reported. We present a male patient previously diagnosed with CADASIL, who had suffered an ischemic vascular cerebral accident with a MRI compatible with leukoencephalopathy, and who was dependent for daily activities, and sustained dementia, mood alterations, apathy, and urine incontinence. He had famil-ial antecedents of psychiatric symptoms and ischemic stroke events in several relatives including his father, two brothers and one sister. He was scheduled for arthrodesis of the le…
ASPERGILOSIS PULMONAR INVASIVA EN PACIENTES CON SINDROME DE DISTRÉS RESPIRATORIO POR COVID-19
2021
Resumen Los pacientes con COVID-19 que ingresan en una unidad de cuidados intensivos (UCI), tienen un alto riesgo de desarrollar infecciones secundarias, incluyendo infecciones fungicas invasivas como aspergilosis pulmonar invasiva (API). El objetivo principal fue el analisis de los casos con sospecha de COVID-19 Associated Pulmonary Aspergillosis (CAPA) en nuestra unidad. En estos pacientes realizamos cultivo micologico en el lavado broncoalveolar como metodos de aislamiento de Aspergillus sp. Se siguio el algoritmo AspICU para establecer el diagnostico de API probable. Ademas, considerando tambien relevante la positividad del antigeno de galactomanano. Se confirmo API probable en 3 de ell…