Search results for "Crohn's Disease"
showing 10 items of 242 documents
Epidemiological aspects of Crohn’s disease
2015
Crohn’s Disease (CD) is considered a result of multifactorial interplay between genetic, immune-related, environmental, and infectious triggers all contributing into evolution of clinical disease. The age of onset of Crohn’s disease has a bimodal distribution. The first peak occurs between the ages of 15 and 30 years (late adolescence and early adulthood), and the second occurs mainly in women between the ages of 60 and 70 years. In general, the frequency of CD is similar in males and females, with some studies showing a very slight female predominance. The rate of Crohn’s disease is 1.1–1.8 times higher in women than in men. This pattern is reversed with pediatric CD, which has a higher in…
Splenic tuberculosis in a patient with Crohn's disease on infliximab: Case report
2010
P717 Ustekinumab in Crohn’s disease: Real-world outcomes from the Sicilian Network for inflammatory bowel diseases (SN-IBD):–Preliminary results
2020
Abstract Background Ustekinumab is approved in Europe for the treatment of moderate-to-severe Crohn’s disease (CD) since 2016. Italian real-life data on efficacy and safety are scarce. The aim of this study was to assess effectiveness, safety and usage of Ustekinumab in an Italian cohort of patients. Methods Data of patients with moderate-to-severe CD who started Ustekinumab in Sicily were extracted from the database of the SN-IBD. Demographic data, disease-related data (disease duration, location, clinical activity) and previous therapies with biologics were collected. The primary study endpoints were steroid-free clinical remission and steroid-free clinical response at week 12, 24 and 52 …
La resonancia magnética y el índice MaRIA en la valoración preoperatoria de la enfermedad de Crohn ileal
2019
Abstract Introduction Accurate quantification of the inflammatory activity in Crohn’s Disease is essential to decide the adequate treatment for each patient. The aim of the present study is to assess the correlation between the pre-operative Magnetic Resonance Index of Activity (MaRIA) and the histologic degree of inflammation from surgically resected intestinal Crohn’s Disease lesions. Methods This is a prospective study including a consecutive case series of patients with small bowel Crohn’s Disease, who underwent surgical resection. A Magnetic Resonance Enterography was performed during the three months prior to surgery, applying a pre-established protocol. Relative contrast enhancements…
Verlaufskontrolle des Morbus Crohn: Kann die Hydro-MRT die fraktionierte Magen-Darm-Passage ersetzen?
1997
PURPOSE: To compare the value of hydro-MRI with follow-through examinations in the follow-up of Crohn's disease. METHOD: 22 patients known to be suffering from Crohn's disease were examined via 1.5 T-MR system; an oral contrast examination using 1000 ml of a 2.5% mannitol solution was performed in all patients. T2-weighted TSE sequences and T1-weighted SE sequences were performed before and after the intravenous injection of Gd-DTPA. To reduce movement artifacts caused by peristalsis of the gut, intravenous injection of 40 mg Buscopan was given. The findings of hydro-MRI were compared with the follow-through examinations. RESULTS: In the upper gastrointestinal tract, the follow-through exam…
Infliximab prevents Crohn's disease recurrence after ileal resection.
2009
Physicians’ Knowledge and Application of Immunization Strategies in Patients with Inflammatory Bowel Disease: A Survey of the Italian Group for the S…
2019
<b><i>Background:</i></b> No data on European countries about knowledge and application of immunization strategies in patients with inflammatory bowel disease (IBD) are available. <b><i>Objectives:</i></b> We designed a questionnaire aimed at exploring these issues among Italian gastroenterologists dealing with adult and paediatric IBD. <b><i>Methods:</i></b> An anonymous, 24-item, questionnaire was sent via e-mail to all members of the Italian Group for the study of Inflammatory Bowel Disease. Three sets of questions were formulated: (1) Characteristics of respondents; (2) General opinions on the role of vaccines in IB…
Adalimumab vs Azathioprine in the Prevention of Postoperative Crohn's Disease Recurrence. A GETECCU Randomised Trial.
2017
Background and aims Postoperative recurrence of Crohn's disease [POR-CD] is almost certain if no prophylaxis is administered. Evidence for optimal treatment is lacking. Our aim was to compare the efficacy of adalimumab [ADA] and azathioprine [AZA] in this setting. Methods We performed a phase 3, 52-week, multicentre, randomised, superiority study [APPRECIA], in which patients with ileocolonic resection were randomised either to ADA 160-80-40 mg subcutaneously [SC] or AZA 2.5 mg/kg/day, both associated with metronidazole. The primary endpoint was endoscopic recurrence at 1 year [Rutgeerts i2b, i3, i4], as evaluated by a blinded central reader. Results We recruited 91 patients [median age 35.…
Large retroperitoneal abscess extended to the inferior right limb secondary to a perforated ileal Crohn’s disease: the importance of the multidiscipl…
2016
The typical complications of Crohn's disease concerns small and large bowel. The full thickness inflammation of the intestinal wall develops in strictures, fistulas and abdominal abscesses. Nowadays the most accepted therapeutic for intra-abdominal abscess option is antibiotic therapy and, in case of need, percutaneous drainage of the abscess. If the abscess passes through the pelvic foramen the abscess can involve the inferior limbs. We report a case a perforation of terminal ileum in Crohn's disease complicated by a large abscess of the right iliac fossa reaching the spaces between the anterior lateral muscles of the right thigh as far as the anterior lateral pre-tibial region. We discuss…
MDCT Enteroclysis and Enterography
2015
Since the first studies suggesting its possible role in the management of Crohn’s disease patients, multidetector computed tomography has usually been considered a useful diagnostic technique in Crohn’s disease for the detection of extraenteric complications, as intra-abdominal abscesses, the study of strictures, prestenotic dilatations, fistulas, and postsurgical complications. Moreover, it is a widely available technique and is considered the gold standard in emergency.