Search results for "Crohn"

showing 10 items of 379 documents

Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)

2016

Background & Aims: A novel family of proton-sensing G-proteinâcoupled receptors, including ovarian cancer G-proteinâcoupled receptor 1 (OGR1) (GPR68) has been identified to play a role in pH homeostasis. Hypoxia is known to change tissue pH as a result of anaerobic glucose metabolism through the stabilization of hypoxia-inducible factor-1α. We investigated how hypoxia regulates the expression of OGR1 in the intestinal mucosa and associated cells. Methods: OGR1 expression in murine tumors, human colonic tissue, and myeloid cells was determined by quantitative reverse-transcription polymerase chain reaction. The influence of hypoxia on OGR1 expression was studied in monocytes/macrophages and…

WT wild type0301 basic medicineMM6 MonoMac 6HV healthy volunteerSPARC secreted protein acidic and rich in cysteineNF-κB nuclear factor-κBInflammationBiologyIEC intestinal epithelial cell03 medical and health sciencesIntestinal mucosaTDAG8Ovarian Cancer G-Protein–Coupled ReceptormedicineOGR1 ovarian cancer G-protein–coupled receptor 1 (GPR68)IFN interferonlcsh:RC799-869ReceptorOriginal ResearchTh T-helperInflammationTNF tumor necrosis factorIBD inflammatory bowel diseaseHepatologyRT-qPCR quantitative reverse-transcription polymerase chain reactionAICAR 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranosideTDAG8 T-cell death-associated gene 8 (GPR65)Inflammatory Bowel DiseaseGRP65GastroenterologyHypoxia (medical)Molecular biologyGPR G-protein–coupled receptormRNA messenger RNAIL interleukinChIP chromatin immunoprecipitationHIF hypoxia-inducible factorUC ulcerative colitis030104 developmental biologyHypoxia-inducible factorsCancer researchCD Crohn's diseaselcsh:Diseases of the digestive system. GastroenterologyTumor necrosis factor alphaFCS fetal calf serummedicine.symptomChromatin immunoprecipitationHomeostasisCellular and Molecular Gastroenterology and Hepatology
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Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase

2015

Background & Aims: Plasma levels of high-density lipoprotein (HDL) cholesterol are frequently found decreased in patients with inflammatory bowel disease (IBD). Therefore, and because HDL exerts anti-inflammatory activities, we investigated whether HDL and its major protein component apolipoprotein A-I (apoA-I) modulate mucosal inflammatory responses in vitro and in vivo. Methods: The human intestinal epithelial cell line T84 was used as the in vitro model for measuring the effects of HDL on the expression and secretion of tumor necrosis factor (TNF), interleukin-8 (IL-8), and intracellular adhesion molecule (ICAM). Nuclear factor-κB (NF-κB)-responsive promoter activity was studied by …

WT wild typeApolipoprotein BEMSA electrophoretic mobility shift assayMPO myeloperoxidaseIκB kinaseDSS dextran sodium sulphatemTOR the mammalian target of rapamycinRT-PCR real-time polymerase chain reactionNF-κBchemistry.chemical_compound540 ChemistryApoA-I apolipoprotein A-I10038 Institute of Clinical ChemistryOriginal ResearchTNF tumor necrosis factorbiologyIBD inflammatory bowel diseaseChemistryGastroenterologyMyeloperoxidase10076 Center for Integrative Human PhysiologyMEICS murine endoscopic index of colitis severityTumor necrosis factor alphalipids (amino acids peptides and proteins)3-MA 3-methyl adenineNF-κB nuclear factor κBHDL high-density lipoproteinLC3II light chain 3 IIPBS phosphate-buffered salinep-IKK phosphorylated IκB kinase610 Medicine & healthICAM intracellular adhesion molecule246-Trinitrobenzenesulfonic acidTg transgenicmedicineAutophagyCD Crohn’s disease2715 GastroenterologyColitislcsh:RC799-869KO knockoutHepatologyApolipoprotein A-IAutophagyInflammatory Bowel DiseaseTNBS 246-trinitrobenzenesulfonic acidmedicine.diseaseMolecular biologyIL interleukinsiRNA small interfering RNAPI-3 phosphatidylinositol-3Immunologybiology.protein2721 Hepatologylcsh:Diseases of the digestive system. GastroenterologyPFA paraformaldehydeLipoproteinDAPI 4′6-diamidino-2-phenylindoleCMGH Cellular and Molecular Gastroenterology and Hepatology
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Determinación de anticuerpos anti-Anisakis y relación con las subpoblaciones linfocitarias αβ Y γδ en pacientes con Enfermedad de Crohn

2015

La enfermedad de Crohn (EC) es una enfermedad de etiopatogenia y fisiopatología compleja, que se desarrolla sobre una base de múltiples alteraciones inmunes, tanto de la inmunidad innata como de la inmunidad adquirida. Siguiendo nuestra línea de investigación en relación a la deficiencia de LTγδ en pacientes con enfermedad de Crohn, planteamos la hipótesis de trabajo de que parásitos como Anisakis simplex, ingerido frecuentemente mediante el consumo de pescado, podrían aprovechar este estado de inmunidad alterada en la enfermedad de Crohn para infectar con mayor frecuencia a estos pacientes que a la población sana. Hemos realizado un estudio prospectivo de casos y controles desde junio de 2…

anticuerpos anti-AnisakisUNESCO::CIENCIAS MÉDICAS ::Medicina interna::Gastroenterología:CIENCIAS MÉDICAS ::Medicina interna::Gastroenterología [UNESCO]linfocitos gamma deltapoblaciones linfocitariasEnfermedad de CrohnAnisakidosis
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Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.

2008

Background & Aims Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-β signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-β signaling is impaired because of high expression of the inhibitory molecule Smad7. Although no intrinsic defects in Tregs function have been shown in IBD, it is still unknown whether colitogenic T cells are susceptible to Treg-mediated suppression. In this study, we have investigated whether IBD mucosal CD4+ T cells are resistant to Tregs and whether Smad7 is involved in this process. Methods IBD lamina propria mononuclear cells …

antisense oligonucleotideCD4-Positive T-LymphocytesAdoptive cell transferT-Lymphocytesanimal cellCell CommunicationInbred C57BLT-Lymphocytes RegulatoryTransgenicMiceregulatory T lymphocyteCrohn DiseaseTransforming Growth Factor betamononuclear cellRAG1 proteinIntestinal MucosaenteritisCells CulturedMice KnockoutSettore MED/12 - GastroenterologiaCulturedintegumentary systemmedicine.diagnostic_testarticleGastroenterologyInterleukinhemic and immune systemsT helper cellColitisRegulatoryUp-Regulationmedicine.anatomical_structurepriority journalgamma interferonSignal TransductionRegulatory T cellColonCellsKnockoutanimal experimentinterleukin 6chemical and pharmacologic phenomenaMice TransgenicBiologyinterleukin 2Recombination-activating geneFlow cytometryProinflammatory cytokineSmad7 ProteinmedicineAnimalsHumanscontrolled studyhumanlamina propriamouseCell ProliferationHomeodomain ProteinsCD4+ T lymphocytenonhumanHepatologyAnimalflow cytometryhuman cellanimal cell culturetransgenic mouseMice Inbred C57BLDisease Models Animalantisense oligonucleotide; gamma interferon; interleukin 17; interleukin 2; interleukin 6; RAG1 protein; Smad7 protein; animal cell; animal cell culture; animal experiment; article; CD4+ T lymphocyte; cell proliferation; colitis; controlled study; enteritis; flow cytometry; human; human cell; knockout mouse; lamina propria; mononuclear cell; mouse; nonhuman; priority journal; regulatory T lymphocyte; transgenic mouse; Animals; CD4-Positive T-Lymphocytes; Cell Communication; Cell Proliferation; Cells Cultured; Colitis; Colon; Crohn Disease; Disease Models Animal; Homeodomain Proteins; Humans; Intestinal Mucosa; Mice; Mice Inbred C57BL; Mice Knockout; Mice Transgenic; Signal Transduction; Smad7 Protein; T-Lymphocytes Regulatory; Transforming Growth Factor beta; Up-RegulationDisease ModelsImmunologyinterleukin 17knockout mouseTransforming growth factorGastroenterology
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Caracterización de biomarcadores en la recurrencia post-quirúrgica de la enfermedad de Crohn: valor predictivo e implicación patogénica

2017

A pesar de un conocimiento cada vez mayor sobre la patogenia de la enfermedad de Crohn (EC) y el desarrollo de esquemas de tratamiento más potentes que incluyen los fármacos biológicos, las tasas de cirugía en estos pacientes siguen siendo elevadas. Así, un 50-60% de los pacientes con EC requieren de una resección intestinal en los primeros 10 años tras el diagnóstico, y un 25% de éstos acabarán requiriendo de una segunda cirugía dentro de los 5 años siguientes. Dado que la cirugía no supone un tratamiento curativo, la reaparición de lesiones tras la resección de todo el tramo intestinal afecto (fenómeno conocido como recurrencia post-quirúrgica) es muy frecuente en estos pacientes, a pesar…

biomarcadoresFisiopatología de las enfermedades gastrointestinalesrecurrencia post-quirúrgicaenfermedad de crohnCiencias de la salud
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Prevalence of endodontic infection in patients with Crohn ́s disease and ulcerative colitis

2021

[Background] Previous studies have linked apical periodontitis (AP) to inflammatory bowel disease (IBD). The aim of this study was to compare the prevalence of AP and root canal treatment (RCT) in patients with ulcerative colitis (UC) and Crohn ́s disease (CD).

burning mouth syndromeCrohn’s diseasemedicine.medical_specialtyMultivariate analysisRoot canalefficacyDiseaseLogistic regressionInflammatory bowel diseaseGastroenterologyInflammatory bowel disease03 medical and health sciences0302 clinical medicinesystematic reviewCrohn DiseaseToot canal treatmentApical periodontitisInternal medicinePrevalencemedicineHumansGeneral DentistryUNESCO:CIENCIAS MÉDICASPeriodontitisCrohn's diseaseOral Medicine and Pathologybusiness.industryResearch030206 dentistrylow level laser therapymedicine.diseaseUlcerative colitisdigestive system diseasesRoot Canal TherapyCross-Sectional Studiesmedicine.anatomical_structureOtorhinolaryngologyUlcerative colitisColitis UlcerativeSurgerybusinessPeriapical Periodontitis
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Efficacy of non-surgical periodontal treatment on patients with coronary artery disease: a meta-analysis of randomized controlled trials

2022

Coronary artery disease (CAD) is defined as one of the most common cardiovascular diseases (CVDs). Periodontitis is one of the risk factors for CAD. PubMed, Embase and Cochrane Library databases were carefully and thoroughly retrieved until October 2021. On the basis of the inclusion and exclusion criteria, eligible articles were selected strictly to identify randomized controlled trials (RCTs). Using Cochran's Q statistic, Review Manager 5.4 and Stata 16, data were extracted, and a comprehensive analysis was carried out. Six RCTs of 619 patients were included in this study, including 360 in the intervention group (IG) and 259 in the control group (CG). Meta-analysis showed significant diff…

crohn's diseaseCholesterol HDLCoronary Artery DiseaseCholesterol LDLaphthous stomatitisC-Reactive ProteinOtorhinolaryngologyinflammatory bowel diseasesystemic extraintestinal manifestationsHumansSurgeryundeterminedGeneral DentistryUNESCO:CIENCIAS MÉDICASTriglyceridesulcerative colitisRandomized Controlled Trials as TopicMedicina Oral Patología Oral y Cirugia Bucal
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Severe cutaneous psoriasis after certolizumab pegol treatment;report of a case.

2009

crohn's diseasePsoriasisCerolizumab
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Exactitud diagnóstica de la resonancia magnética preoperatoria en la determinación de la extensión y grado de actividad inflamatoria de la enfermedad…

2014

Introducción: La correcta identificación de la localización y cuantificación de la actividad inflamatoria de las lesiones de la enfermedad de Crohn es necesaria para establecer cuál es el manejo más adecuado para cada paciente Métodos: Se trata de un estudio prospectivo observacional consecutivo que abarca un periodo de estudio de 30 meses. El diagnóstico se realiza según los criterios de Lennard-Jones y la clasificación de Montreal. Se realizó una resonancia magnética mediante enterografía, con el mismo protocolo y secuencias, en los tres meses previos a la cirugía. Se determinaron las características radiológicas de las lesiones, se obtuvo el índice de actividad de la resonancia magnética…

curvas dinámicas de captación:CIENCIAS MÉDICAS::Ciencias clínicas::Radiología [UNESCO]:CIENCIAS MÉDICAS::Cirugía::Cirugía abdominal [UNESCO]fibrosisUNESCO::CIENCIAS MÉDICAS::Medicina interna::Gastroenterologíacalprotectina fecalesferas de calibraciónUNESCO::CIENCIAS MÉDICAS::Ciencias clínicas::Radiología:CIENCIAS MÉDICAS::Medicina interna::Gastroenterología [UNESCO]MaRIAenfermedad de CrohnUNESCO::CIENCIAS MÉDICAS::Cirugía::Cirugía abdominalactividad inflamatoria intestinalresonancia magnética
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Comment to “Management of cytomegalovirus infection in inflammatory bowel diseases”

2012

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cytomegaloviruHepatologybusiness.industryGastroenterologyInflammatory Bowel DiseasesAntiviral AgentsInflammatory bowel diseaseCytomegalovirus infectionCrohn DiseaseCytomegalovirus InfectionsImmunologyHumansMedicineColitis Ulcerativecytomegalovirus; Inflammatory bowel diseasebusinessGanciclovircytomegalovirusImmunosuppressive AgentsDigestive and Liver Disease
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