Search results for "Cyclin"
showing 10 items of 1021 documents
Investigating the Viability of Multi-Recycling of Asphalt Mixtures through a Preliminary Binder Level Characterization
2022
The incorporation of reclaimed asphalt (RA) in hot mix asphalt mixtures is widely considered a sustainable solution for road infrastructure development. Under the scope of the circular economy (CE), the multiple recycling capability of RA has to be assessed in order to ensure its performance at each recycling cycle and also its viability with different additives. The performance of asphalt mixtures with RA strongly depends on the type of rejuvenator, binder, and their degree of blending in the mix. For this reason, it is essential to know the properties of the aged binder extracted from RA to better understand its rheological properties and optimal dosage of rejuvenation to design a satisfa…
Toward the Decarbonization of Plastic: Monopolymer Blend of Virgin and Recycled Bio-Based, Biodegradable Polymer.
2022
Decarbonization of plastics is based on two main pillars: bio-based polymers and recycling. Mechanical recycling of biodegradable polymers could improve the social, economic and environmental impact of the use of these materials. In this regard, the aim of this study was to investigate whether concentrations of the same recycled biopolymer could significantly affect the rheological and mechanical properties of biodegradable monopolymer blends. Monopolymer blends are blends made of the same polymers, virgin and recycled. A sample of commercially available biodegradable blend was reprocessed in a single-screw extruder until two extrusion cycles were completed. These samples were exposed to gr…
How a Second Mg2+ Ion Affects the Phosphoryl-Transfer Mechanism in a Protein Kinase: A Computational Study
2020
Mg2+ ions are essential for the proper functioning of protein kinases, and their roles in kinase activity have been studied for years. However, recent investigations have shed light on how these me...
How a Second Mg2+ Ion Affects the Phosphoryl Transfer Mechanism in a Protein Kinase: A Computational Study
2020
<div>In this contribution, the phosphoryl transfer reaction in CDK2 has been studied in detail considering the presence of an additional Mg2+ ion in the active site. For this purpose, QM/MM (quantum mechanics/molecular mechanics) free energy calculations with the adaptive string method were performed, which showed that indeed the system containing two Mg2+ ions exhibits a lower activation free energy, corroborating the experimental observations.</div>
Modulation of protein phosphorylation by natural products
2002
Studies carried out to determine the influence of phosphorylation and dephosphorylation of proteins in a variety of physiological events are of increasing interest. The activity of kinases and phosphatases and their respective inhibition by endogenous mediators and by pharmacological agents regulates a huge number of biochemical pathways involved in cellular proliferation, apoptosis, inflammation, hormonal activity, and gene transcription, amongother processes. This article focuses on the recently described natural products able to interfere negatively with the activity of serine/threonine and tyrosine kinases. These agents are classified, according to theirbiosynthetic origin and chemical …
Concurrent endurance and strength training : neuromuscular, cardiorespiratory and hormonal effects of the exercise order in previously untrained and …
2015
The aim of the present thesis was two-fold. First, to investigate physiological adaptations to concurrent endurance and strength training performed in the same session with different exercise orders (i.e. commencing training with endurance or strength, respectively; E+S vs. S+E) in previously untrained men (n=42) (study 1). Second, to examine physiological adaptations when strength training was always performed immediately after endurance running in the same session (E+S) compared to endurance training alone (E) in recreational endurance runners (n=30) (study 2). In study 1, training consisted of 2 - 3 weekly combined endurance cycling and mixed hypertrophic and maximal strength training se…
Effects of stump removal on soil decomposer communities in undisturbed patches of the forest floor
2011
Soil preparation after clear-cutting leads to fragmentation of forest floor and, consequently, changes the habitat of decomposers. Stump removal for bioenergy is further increasing the disturbance in the soil. We studied responses of decomposers to stump removal in boreal spruce forests during the first 4 years after clear felling in relation to mounding. Samples for each decomposer organism group were taken from undisturbed forest floor patches that are the main habitat for decomposers after forest regeneration and whose amount and size obviously differ between the treatments. Microbial biomasses and community structure, and the abundance of enchytraeids, were not found to be affected by t…
Importance of static adjustment of knee angle to determine saddle height in cycling
2016
Knee flexion angle is used to determine saddle height during pedaling. However, it is unclear if knee flexion angle at upright standing posture affects measures and interpretation of knee flexion angle during cycling. The objective of this study was to assess the importance of adjusting knee angle during pedaling according to the knee angle at upright posture. Seventeen cyclists performed three 10 min cycling trials at different saddle heights to induce knee flexion angles (40º, 30º or 20º when crank was at the 6 o'clock position). Knee flexion angle was determined at the sagittal plane during cycling using a 2D motion analysis system. Alteration of saddle height was performed by subtractin…
Effect of training on aerobic capacity of female athletes differing in muscle fibre composition
1983
Abstract The effects of endurance training were studied in two groups of female cross‐country skiers who differed in muscle fibre composition. The ST‐group (n = 10) had 56–76% slow twitch (ST) muscle fibres and the FT‐group (n= 10) 40–55% ST fibres in the m. vastus lateralis. During a four‐month period, the subjects trained on the average 81 km per week. The intensive training (heart rate 0–15 beats per min below maximum) averaged 8.5 km per week. The differences in training between the two groups were not significant. The ST‐group significantly increased their cycling maximum oxygen uptake (C max, 4.6%, P <0.01) and the anaerobic threshold (AT, 2.8%, P <0.01) during the training period whe…
Jyväskylän yliopiston ylioppilaskunnan hiili- ja luontojalanjälki
2023
Tässä hankkeessa laskettiin Jyväskylän yliopiston ylioppilaskunnan (JYY) merkittävimpien toimintojen vuoden 2021 hiili- ja luontojalanjälki eli ilmasto- ja luontohaitat. Menetelmä perustuu pääosin muun muassa EXIOBASE ja LC-IMPACT-tietokantoihin, joiden avulla pystytään talouskirjanpitoon perustuen selvittämään eri tuotteiden ja palveluiden aiheuttamat ilmasto- ja luontohaitat sekä niiden maantieteelliset sijainnit. JYY:n vuoden 2021 hiilijalanjälki oli 2017 t CO2e, maaekosysteemeihin kohdistuva luontojalanjälki oli 8,30E-09 PDF (globaali osuus lajeista, jotka ovat riskissä kuolla sukupuuttoon), makean veden ekosysteemeihin kohdistuva luontojalanjälki oli 1,42E-09 PDF ja meriekosysteemeihin…