Search results for "Cystic"

Segmental resection for the excision of two multicystic ameloblastoma

2014

Objectives. The purpose of this study was addressed at the understanding and management in the ameloblastoma treatment, performing a segmental surgical resection. Ameloblastoma represents nearly 1% of all neoplasm located  Annali di Stomatologia 2014; Suppl. 3 to n. 2: 1-41 15 in the oral cavity. In 80% of cases it could be found in the mandible, of these lesions 70% are located in the molar re- gion or the ascending ramus, 20% in the premolar region and 10% in the anterior part. It is considered as a benign neoplasm with slow growing-pattern and locally aggressive behaviour. Methods. On the basis of clinicoradiological findings, ameloblastoma is divided into 3 groups: solid or multicyst…

Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs

In Cystic fibrosis (CF) disease nonsense mutations in the CFTR gene cause the absence of the CFTR protein expression and a more severe form of the disease. About 10% of patient affected by CF show a nonsense mutation. A potential treatment of this alteration is to promote translational readthrough of premature termination codons (PTCs) by translational readthrough inducing drugs such as Ataluren (1). We reported a rationale for Ataluren promoted readthrough of PTCs by computational approach and GFP-reporter cell-based assay (2) and the observed enhancement of readthrough activity by some Ataluren derivatives (3, 4). In this context we aimed to compare the 1,2,4-oxadiazole core of Ataluren w…

Diet to Reduce the Metabolic Syndrome Associated with Menopause. The Logic for Olive Oil

2020

The rates of metabolic syndrome are increasing in parallel with the increasing prevalence of obesity, primarily due to its concomitant insulin resistance. This is particularly concerning for women, as the years around menopause are accompanied by an increase in visceral obesity, a strong determinant of insulin resistance. A fall in estrogens and increase in the androgen/estrogen ratio is attributed a determining role in this process, which has been confirmed in other physiological models, such as polycystic ovary syndrome. A healthy lifestyle, with special emphasis on nutrition, has been recommended as a first-line strategy in consensuses and guidelines. A consistent body of evidence has ac…

OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS

2018

Are disclosed oxadiazole derivatives, their use as medicaments and in particular for the treatment of diseases associated with the presence of a nonsense mutation in the gene or a premature stop codon in the mRNA, pharmaceutical formulation comprising said oxadiazole derivatives and prodrug or mixture thereof and the methods for the preparation of said Oxadiazole derivatives.

Use of antiepileptic drugs in women with polycystic ovary syndrome

2005

Endothelial abnormalities in young women with PCOS: correlations with insulin resistance and decreased levels of serum adiponectin

2006

Abstract PURPOSE: Polycystic ovary syndrome (PCOS) is an extremely prevalent disorder in which elevated blood markers of cardiovascular risk and altered endothelial function have been found. This study was designed to determine if abnormal carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) in young women with PCOS may be explained by insulin resistance and elevated adipocytokines. METHODS: A prospective study in 50 young women with PCOS (age: 25.2 +/- 1 years; body mass index [BMI]: 28.7 +/- 0.8) and 50 matched ovulatory controls (age: 25.1 +/- 0.7 years; BMI: 28.5 +/- 0.5) was performed. Carotid IMT, brachial FMD, and blood for fasting glucose, insulin, leptin, …

Evaluation and improvement of the quality of the discharge prescription in Cystic Fibrosis children hospitalised for intravenous antibiotic therapy

2017

1.Antecedentes. La Fibrosis Quística (FQ) es una enfermedad conocida desde la edad media, aunque durante esa época no estaba descrita como tal sino más bien como un hechizo maligno. En 1943, Farber propuso el término mucoviscidosis y este término se sigue utilizando en la actualidad. La FQ es la enfermedad hereditaria autosómica recesiva grave más frecuente en la población blanca, con una incidencia en Europa que oscila entre 1:1.353 en Irlanda y entre 1:25.000 en Finlandia, y una frecuencia de portadores de 1 por cada 2527. Es una enfermedad de las células epiteliales exocrinas, que se caracteriza por la producción de un moco espeso y viscoso que obstruye los conductos del órgano donde se …

Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells

2016

Odontogenic calcificant cystic tumor : a report of two clinical cases

2007

Odontogenic Calcificant Cystic Tumor (OCCT) is an infrequent injury. It arises from odontogenic epithelial rests present in the maxilla, jaw or gum. Gorlin and col. described the OCCT for first time as an own pathological entity in 1962. Clinically, the OCCT represents 1% of the odontogenic injuries. It is possible to be found from the first decade to the eighth decade. It affects in same proportion the maxilla and the jaw, being the most common in the dented zones, with greater incidence in the first molar area. Two case reports of OCCT in two different ages, both in female individuals, one at 5 years old and the other at 35 years old are presented. Enucleation of the tumor was the treatme…

A case report of coexistence of a sialolith and an adenoid cystic carcinoma in the submandibular gland

2006

Ôhe occurrence of sialoliths in the submandibular gland is 80% due to the specific anatomy of both the gland and its duct. The diagnosis is rather easy because of the obvious clinical signs of the entity. Imaging studies are always necessary in order to treat the patient as effectively as possible. The stones do not tend to occur within the gland as frequently as in the respective duct. The coexistence of sialoliths and malignant tumors is extremely rare. A 70-year-old woman with intraparenchymal stone was operated in our ENT department. In addition to the sialolith the pathological examination revealed the existence of an adenoid cystic carcinoma (ACC), that extended to the neighboring ske…