Search results for "D region"
showing 10 items of 235 documents
Rethinking Regional Innovation Systems to capture regions’ variety
2014
Over the last few decades the concept of Regional Innovation Systems has given rise to a line of research which aims to highlight the functioning of network relationships and their importance in the innovation process at a meso-economic level. Despite limitations, this approach has thrown up some interesting reflections on the systemic nature of the process of innovation at regional level. It proposes some insights to draw an interpretive framework which includes elements for analysing disparate regions. The aim of this paper is to highlight the main aspects of the issue that might allow to go over in the debate opening up perspectives for analysing regional systems of innovation, both adva…
Il regionalismo differenziato di cui all'art. 116, co. 3, della Costituzione: un tentativo di inquadramento sistematico nel Titolo V della Costituzio…
2021
The paper analyzes the origins and characteristics of the differentiated re- gionalism referred to in art. 116.3 of the Constitution, highlighting the impact that its implemen- tation could have in Title V of the Constitution, in relation to both ordinary regions and regions with special status. The widespread nature of differentiated regionalism could, in particular, lead to the definitive, tough gradual, overcoming of regional uniformity, towards a model of mainly differentiable regionalism.
Pianificazione regionale al bivio: un piano territoriale regionale strategico a valenza sociale economica o un piano comprensivo
2022
With the approval of the regional law n.2 / 2021 the Sicilian regional urban reform has taken the start that has been completed with the last of the implementing decrees provided for in the regional law n.19 / 2020 relating to the sizing of general urban plans (PUG) that take the place of the PRG of the lr n.71 / 1978. This last law was part of the triptych of laws (urban planning, cultural heritage and tourism) that between 1976 and 1980 were alternately desired by Piersanti Mattarella before his murder at the hands of the mafia. The regional council has approved the act of address that constitutes the document of the guidelines for the new regional territorial plan of social and economic …
Complex Contribution of the 3′-Untranslated Region to the Expressional Regulation of the Human Inducible Nitric-oxide Synthase Gene
2000
Cytokine stimulation of human DLD-1 cells resulted in a marked expression of nitric-oxide synthase (NOS) II mRNA and protein accompanied by only a moderate increase in transcriptional activity. Also, there was a basal transcription of the NOS II gene, which did not result in measurable NOS II expression. The 3′-untranslated region (3′-UTR) of the NOS II mRNA contains four AUUUA motifs and one AUUUUA motif, known to destabilize the mRNAs of proto-oncogenes, nuclear transcription factors, and cytokines. Luciferase reporter gene constructs containing the NOS II 3′-UTR showed a significantly reduced luciferase activity. The embryonic lethal abnormal vision (ELAV)-like protein HuR was found to b…
Single cell 3’UTR analysis identifies changes in alternative polyadenylation throughout neuronal differentiation and in autism
2020
SUMMARYAutism spectrum disorder (ASD) is a neurodevelopmental disease affecting social behavior. Many of the high-confident ASD risk genes relate to mRNA translation. Specifically, many of these genes are involved in regulation of gene expression for subcellular compartmentalization of proteins1. Cis-regulatory motifs that often localize to 3’- and 5’-untranslated regions (UTRs) offer an additional path for posttranscriptional control of gene expression. Alternative cleavage and polyadenylation (APA) affect 3’UTR length thereby influencing the presence or absence of regulatory elements. However, APA has not yet been addressed in the context of neurodevelopmental disorders. Here we used sing…
RETURN MIGRATION TRENDS IN LATVIA: RE-ATTRACTING THE MAIN HUMAN RESOURCE FOR SUSTAINABLE REGIONAL DEVELOPMENT
2019
This study is devoted to the research of human resources as a main source of sustainable regional development in Latvia. It is focused on two key concepts of human capital and migration. The aim of the study is to explore return migration geographies by looking at young return migrants as a resource and preconditions for sustainable regional development essential to Latvia.Return migration to the regions of Latvia is examined by two main research questions. What are the most recent return migrant characteristics in Latvia? How does return migration of young Latvians translates into regional geographies of return migration?Drawing on most recent available statistical data we elaborate on the…
Specific Recognition of the 5′-Untranslated Region of West Nile Virus Genome by Human Innate Immune System
2022
In the last few years, the sudden outbreak of COVID-19 caused by SARS-CoV-2 proved the crucial importance of understanding how emerging viruses work and proliferate, in order to avoid the repetition of such a dramatic sanitary situation with unprecedented social and economic costs. West Nile Virus is a mosquito-borne pathogen that can spread to humans and induce severe neurological problems. This RNA virus caused recent remarkable outbreaks, notably in Europe, highlighting the need to investigate the molecular mechanisms of its infection process in order to design and propose efficient antivirals. Here, we resort to all-atom Molecular Dynamics simulations to characterize the structure of th…
Thermal remote sensing from Airborne Hyperspectral Scanner data in the framework of the SPARC and SEN2FLEX projects: an overview
2009
Abstract. The AHS (Airborne Hyperspectral Scanner) instrument has 80 spectral bands covering the visible and near infrared (VNIR), short wave infrared (SWIR), mid infrared (MIR) and thermal infrared (TIR) spectral range. The instrument is operated by Instituto Nacional de Técnica Aerospacial (INTA), and it has been involved in several field campaigns since 2004. This paper presents an overview of the work performed with the AHS thermal imagery provided in the framework of the SPARC and SEN2FLEX campaigns, carried out respectively in 2004 and 2005 over an agricultural area in Spain. The data collected in both campaigns allowed for the first time the development and testing of algorithms for …
SOILPRO: a LIFE+ project implementing soil monitoring and protection together with regional stakeholders of Sicily and Peloponnese.
2011
According to the Thematic Strategy for Soil Protection, the LIFE+ ENV/IT/00428 SOILPRO project (http://www.soilpro.eu) has the overall objective of slowing down the progress of soil degradation in EU Member States, and supporting local and regional authorities (LRAs) in the identification and monitoring of risk areas. The monitoring of the on-going soil degradation processes and the evaluation of different protection measures are realized through a web-based application (SMS – Soil Monitoring System), developed according to data and knowledge obtained from the different project partners. The SMS was initially applied on the whole Sicily (Italy) and Peloponnese (Greece) regions and then test…
Comparing the Impact of Electric Vehicles on Urban and Insular Networks
2022
Transport sector is moving towards clean and green transportation with the growing market of electric vehicles globally. Electric vehicles are independent fossil fuels consumption, but the massive adoption of electric vehicles soon can lead to a significant burden on the power distribution networks. In this paper, a study on the potential impact of electric vehicles on the power distribution networks of two different regions with totally different realities of population density, an average number of cars per inhabitant, and travel habits has been carried out. The first region is the island of Favignana having an insular power distribution network, while the other region, the city of Palerm…