Search results for "D11"
showing 10 items of 337 documents
Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.
2003
Dendritic cells (DCs)(*) fulfill an important regulatory function at the interface of the innate and adaptive immune system. The thymus and activation-regulated chemokine (TARC/CCL17) is produced by DCs and facilitates the attraction of activated T cells. Using a fluorescence-based in vivo reporter system, we show that CCL17 expression in mice is found in activated Langerhans cells and mature DCs located in various lymphoid and nonlymphoid organs, and is up-regulated after stimulation with Toll-like receptor ligands. DCs expressing CCL17 belong to the CD11b(+)CD8(-)Dec205(+) DC subset, including the myeloid-related DCs located in the subepithelial dome of Peyer's patches. CCL17-deficient mi…
CD11c+ Alveolar Macrophages are a Source of IL-23 During Lipopolysaccharide-Induced Acute Lung Injury
2013
Acute lung injury (ALI) is a severe pulmonary disease causing high numbers of fatalities worldwide. Innate immune responses are an integral part of the pathophysiologic events during ALI. Interleukin 23 (IL-23) is a proinflammatory mediator known to direct the inflammatory responses in various settings of infection, autoimmunity, and cancer. Interleukin 23 has been associated with proliferation and effector functions in T(H)17 cells. Surprisingly, little is known about production of IL-23 during ALI. In this study, we found expression of mRNA for IL-23p19 to be 10-fold elevated in lung homogenates of C57BL/6 mice after lipopolysaccharide (LPS)-induced ALI. Likewise, concentrations of IL-23 …
A role for Toll-like receptor mediated signals in neutrophils in the pathogenesis of the anti-phospholipid syndrome.
2012
The anti-phospholipid syndrome (APS) is characterized by recurrent thrombosis and occurrence of anti-phospholipid antibodies (aPL). aPL are necessary, but not sufficient for the clinical manifestations of APS. Growing evidence suggests a role of innate immune cells, in particular polymorphonuclear neutrophils (PMN) and Toll-like receptors (TLR) to be additionally involved. aPL activate endothelial cells and monocytes through a TLR4-dependent signalling pathway. Whether this is also relevant for PMN in a similar way is currently not known. To address this issue, we used purified PMN from healthy donors and stimulated them in the presence or absence of human monoclonal aPL and the TLR4 agonis…
Trade apprenticeships, schooling and social differentiation in the merchant sector in fourteenth century Valencia
2020
El crecimiento económico de Valencia desde finales del siglo XIV implicó el cambio en la formación profesional y cultural de las élites mercantiles locales. La familia continuó siendo el ámbito de enseñanza escrituraria preferente dado que el objetivo último de esa formación era la transmisión hereditaria intergeneracional de la empresa. La formación abarcaba buena parte de la infancia y pubertad hasta que el joven pasaba a trabajar como contable o factor en el extranjero bajo las órdenes paternas. Este modelo de aprendizaje dependía de los vínculos que cohesionaban las redes de sociabilidad mercantil, compartía superficialmente los instrumentos formales de la contratación del aprendizaje a…
Retórica forense y ars dictaminis en Lo somni, de Bernat Metge
2014
Resumen: Partiendo de la existencia de un propósito de autodefensa en el origen de Lo somni, y tomando como base la evidente formación retórica y dictaminal de su autor, es posible señalar numerosos elementos que se encuadran dentro del género retórico, concretamente del forense o judicial, y también otros pertenecientes al ars dictaminis, ambos géneros cargados de aspectos formales y a priori difícilmente adaptables a un texto de ficción literaria. Estos rasgos retóricos y dictaminales están tan integrados en el estilo del autor que fluyen de forma completamente natural en el texto, en un bello ejemplo de fusión literaria, jurídica y dictaminal. Palabras clave: autodefensa, retórica, ars d…
Remarques diplomàtiques al voltant del document de creació de la Biblioteca Reial de Poblet (Poblet, 20 d'agost de 1380)
1999
This paper analyzes a copy of a document dated at the Monastery of Poblet, 20th August, 1380. It states that the King Pedro el Ceremonioso was in the process of establishing a library in it. The absence of the original document as well as the existence of a single copy and several textual irregularities required a diplomatic analysis of the text, so that it could be adequately used as a historical source.[fr] Le présent article analyse la copie du document daté au Monastère de Poblet le 20 août 1380, selon lequel le roi Pedro el Ceremonioso avrait fondé une bibliothèque à ce monastère. L'absence du document original, Texistence d'une seule copie, ainsi comme la présence de certes irrégulari…
Dendritic cells in liver injury and fibrosis: shortcomings and promises.
2013
SummaryThe phenotype and function of liver dendritic cells (LDCs) are poorly understood. This Snapshot summarizes our current knowledge on LDCs in the healthy and injured liver, and their role in fibrosis progression and reversal. It also draws attention to various pitfalls in the current experimental design and conclusions based on available data.
Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendri…
2019
Despite a broad cell-type tropism, cytomegalovirus (CMV) is an evidentially pulmonary pathogen. Predilection for the lungs is of medical relevance in immunocompromised recipients of hematopoietic cell transplantation, in whom interstitial CMV pneumonia is a frequent and, if left untreated, fatal clinical manifestation of human CMV infection. A conceivable contribution of CMV to airway diseases of other etiology is an issue that so far attracted little medical attention. As the route of primary CMV infection upon host-to-host transmission in early childhood involves airway mucosa, coincidence of CMV airway infection and exposure to airborne environmental antigens is almost unavoidable. For i…
The Late Endosomal Adaptor Molecule p14 (LAMTOR2) Regulates TGFβ1-Mediated Homeostasis of Langerhans Cells
2014
Langerhans cells (LCs), a sub-population of dendritic cells (DCs) in the skin, participate in the regulation of immunity and peripheral tolerance. The adaptor molecule p14 is part of the late endosomal/lysosomal adaptor and mitogen-activated protein kinase and mammalian target of rapamycin (mTOR) activator/regulator (LAMTOR) complex, which mediates the activation of lysosome-associated extracellular signaling regulated kinase (ERK) and the mTOR cascade. In previous work, we demonstrated that CD11c-specific deficiency of p14 disrupts LC homeostasis by affecting the LAMTOR-mediated ERK and mTOR signaling. In this study, we extended our analysis on p14 deficiency specifically in LCs. Langerin-…
Alveolar macrophage dynamics in murine lung regeneration
2012
In most mammalian species, the removal of one lung results in dramatic compensatory growth of the remaining lung. To investigate the contribution of alveolar macrophages (AMs) to murine post-pneumonectomy lung growth, we studied bronchoalveolar lavage (BAL)-derived AM on 3, 7, 14 and 21 days after left pneumonectomy. BAL demonstrated a 3.0-fold increase in AM (CD45(+), CD11b(-), CD11c(+), F4/80(+), Gr-1(-)) by 14 days after pneumonectomy. Cell cycle flow cytometry of the BAL-derived cells demonstrated an increase in S + G2 phase cells on days 3 (11.3 ± 2.7%) and 7 (12.1 ± 1.8%) after pneumonectomy. Correspondingly, AM demonstrated increased expression of VEGFR1 and MHC class II between days…