Search results for "DAMAGE"
showing 10 items of 1289 documents
Tradición romanística y perspectivas de reforma en sede de cláusula penal
2012
El autor analiza el tratamiento legal de la cláusula penal en el Derecho civil español, con especial atención a la regulación que ofrece el Código civil en los artículos 1152 a 1154, las diferentes funciones que la cláusula penal cumple y el distinto régimen presente en la Lex 518 del Fuero Nuevo de Navarra, lo cual evidencia el dualismo habido en el sistema jurídico español entre el Derecho civil común (representado por el Código civil) y el derecho foral o especial (representado por distintas compilaciones de ámbito regional). La regulación del Código civil español configura la pena contractual en primer término como sustitutiva de la indemnización de daños y perjuicios prevista en el art…
Pyrrolo[2,3-h]quinolinones: A new ring system with potent photoantiproliferative activity
2006
A new class of compounds, the pyrrolo[2,3-h]quinolin-2-ones, nitrogen isosters of the angular furocoumarin Angelicin, was synthesized with the aim of obtaining new photochemotherapeutic agents with increased antiproliferative activity and lower undesired toxic effects than the lead compound. Two synthetic pathways were approached to allow the isolation both of the dihydroderivatives 10-17 and of the aromatic ring system 23. Compounds 10-17 showed a remarkable phototoxicity and a great UVA dose dependence reaching IC(50) values at submicromolar level. Intracellular localization of these compounds has been evaluated by means of fluorescence microscopy using tetramethylrhodamine methyl ester a…
The publication of news about the results of R+D+I. How do Spanish researchers perceive it?
2018
El objetivo de este estudio es conocer cúal es la percepción que tienen los investigadores de las universidades españolas sobre el impacto que generan, sobre sus carreras profesionales, las noticias científicas que se publicancon los resultados de sus actividades de Investigación, Desarrollo e Innovación (I+D+i). Para ello, se han seleccionado los datos obtenidos por una encuesta online realizada en el año 2016 de 602 investigadores y profesionales de la comunicación científica de 20 universidades de España, teniendo único requisito que alguna de sus publicaciones hubiera sido objeto de —al menos— una nota de prensa difundida por su universidad en los últimos cinco años. Para el…
ESTIMATED AND EXPERIMENTAL FATIGUE LIVES OF 30CrNiMo8 STEEL UNDER IN-AND OUT-OF-PHASE COMBINED BENDING AND TORSION WITH VARIABLE AMPLITUDES
2007
Abstract— Calculated fatigue lives, based on three criteria for multiaxial random fatigue, were compared with lives obtained from tests on cylindrical specimens of 30CrNiMo8 steel subjected to in- and out-of-phase bending and torsion at variable amplitudes. In the chosen fatigue criteria the expected position of the fracture plane, determined from a variance method for the equivalent stress, were taken into account. The equivalent stress history was related to the rain flow method and fatigue damage was evaluated from the Palmgren–Miner hypothesis. It has been shown that the expected fatigue fracture planes agree with those determined by experiments. The most realistic estimations of fatigu…
Advance in Vascular Phenotype Assessment in Children and Adolescents
2010
Cardiovascular damage occurring in adults finds its roots in risk factors operating early in life. Among the factors influencing cardiovascular risk, blood pressure values represent an important measurable marker of the level of potential cardiovascular risk in children and adolescents. Indeed, there is growing evidence that mild blood pressure elevations are much more common than was thought in the past in a pediatric population. Furthermore, hypertension in childhood has gained ground in cardiovascular medicine thanks to the progress made in several areas of pathophysiological and clinical research.1 It is not uncommon for high blood pressure in the young to be accompanied by evidence of …
Ventilation, oxidative stress and risk of brain injury in preterm newborn
2020
AbstractPreterm infants have an increased risk of cognitive and behavioral deficits and cerebral palsy compared to term born babies. Especially before 32 weeks of gestation, infants may require respiratory support, but at the same time, ventilation is known to induce oxidative stress, increasing the risk of brain injury. Ventilation may cause brain damage through two pathways: localized cerebral inflammatory response and hemodynamic instability. During ventilation, the most important causes of pro-inflammatory cytokine release are oxygen toxicity, barotrauma and volutrauma. The purpose of this review was to analyze the mechanism of ventilation-induced lung injury (VILI) and the relationship…
Challenging Dogma: Thresholds for Genotoxic Carcinogens? The Case of Vinyl Acetate
2002
Although many questions remain unanswered, the general principle of the sequence of events leading to cancer after exposure to genotoxic carcinogens has become increasingly clear. This helps to understand the parameters that influence the shape of the dose-effect curve for carcinogenesis, including metabolic activation and inactivation of carcinogens, DNA repair, cell cycle control, apoptosis, and control by the immune system. A linear dose-response relationship with no observable threshold seems to be a conservative but adequate description for the carcinogenic activity of many genotoxic carcinogens, such as aflatoxin B1, the tobacco-specific nitrosoketone NNK, and probably N,N-diethylnit…
Suppression of extinction with TMS in humans: from healthy controls to patients.
2006
We review a series of studies exemplifying some applications of single-pulse and paired-transcranial magnetic stimulation (TMS) in the study of spatial attention and of its deficits. We will focus primarily on sensory extinction, the failure to consciously perceive a contralesional sensory stimulus only during bilateral stimulation of homologous surfaces. TMS studies in healthy controls show that it is possible either to interfere or modulate the excitability of the parietal cortex during sensory (i.e. tactile and visual) attentional tasks, thus reproducing a condition of virtual extinction. TMS studies in patients with unilateral (mainly right) brain damage show that the modulation of the …
alpha-Tocopherol, MDA-HNE and 8-OHdG levels in liver and heart mitochondria of adriamycin-treated rats fed with alcohol-free beer.
2008
Different studies indicate that oxidative stress and mitochondrial damage are key factors in different pathogenic process. The aim of this study was to investigate the possible protective role of alcohol-free beer on adriamycin-induced (ADR) heart and liver toxicity using biomarkers of oxidative stress. This effect was compared with the effect of alcohol beer intake and with a control group. Rats were randomly divided into six groups. The first group received no adriamycin, was fed with water and was regarded as the control group; the second group was injected with a ADR (two cycles of 5mg/kg); the third and fourth groups were fed with alcohol-free and beer for 21 days, respectively and the…
Influence d'une supplémentation en vitamines sur le rendement de la locomotion après une épreuve d'ultratrail
2006
International audience; Aim: The purpose of this study was to study changes in gross efficiency of locomotion after a prolonged trail running race (3000 m up and 300 m down). The second purpose was to investigate the effectiveness of supplementation in vitamin on gross efficiency variability.Materials and methods: Twenty-two well-trained endurance runners took part in this study. They had to perform four sub maximal tests before, 24, 48 and 72 hours after the race in order to estimate gross efficiency of locomotion and a maximal contraction test in the same period. They were divided in two groups either with supplementation (Isoxan Endurance ®) or without (placebo).Results: In both groups w…