Search results for "DAMAGE"
showing 10 items of 1289 documents
A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.
2015
Background: Na+/H+ exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial inhibition of NHE-1. This review presents progress in understanding the mechanisms of action of these inhibitors, connections with certain genetic mutations and acquired treatment resistance, as well as new patents on them. Methods: A MEDLINE search for original and review articles using key terms, Na+/H+ exchanger, leukemia, cariporide, and …
Molecular dynamics simulations of heavy ion induced defects in SiC Schottky diodes
2018
Heavy ion irradiation increases the leakage current in reverse-biased SiC Schottky diodes. This letter demonstrates, via molecular dynamics simulations, that a combination of bias and ion-deposited energy is required to produce the degradation. Peer reviewed
Arbitraje para conflictos ambientales: una aproximación desde los Derechos Humanos
2020
En la confrontación entre la actividad empresarial y la protección del medio ambiente, pueden producirse daños sobre los derechos fundamentales. Desde una perspectiva de derechos humanos, el arbitraje puede desempeñar un rol importante como mecanismo que puede reducir las barreras de acceso a la justicia para las víctimas de estos conflictos y conseguir una reparación justa para ellas. El objetivo de este artículo es examinar cuáles deben ser los elementos para establecer un adecuado sistema de arbitrabilidad para la reparación del daño derivado de disputas medioambientales. Para ello, la autora se centra en las recientemente aprobadas Reglas de La Haya en Materia de Empresas y Derechos Hum…
Expectation Damages and Bilateral Cooperative Investments
2012
We examine the efficiency of the standard breach remedy expectation damages in a setting where the buyer invests cooperatively and the seller invests both cooperatively and selfishly. Contracts may specify a required quality level and an upper bound to the seller's coordination costs. We find that it is optimal to write an augmented Cadillac contract in which quality is stipulated such that it cannot be met with positive probability together with a very low price. Thus, the seller becomes a residual claimant and the coordination-cost threshold can be used to balance the incentives of the buyer.
Cell Cycle: The Life Cycle of a Cell
2013
“Where a cell arises, there must be a previous cell”. This early statement of Rudolf Virchow already points to the process that is called cell cycle. It describes a series of events leading to cell division and duplication and can be sectioned into phases that are controlled by a collection of proteins interacting with each other, the cyclines and the cycline-dependent kinases. It is mandatory that DNA replication is conservative meaning that its structure and sequence remain unaltered while the DNA is duplicated before the cell actually divides. Checkpoints are responsible for the supervision, proteins such as p53 and RB being the key protagonists in cell cycle control. Upon DNA damage rec…
Dependence of T-lymphocyte activation on the extent of cellular damage
2010
Mechanically damaged cells release intracellular substances, resulting in the activation of CD4- and CD8-positive T-lymphocytes. The goal of this investigation was to quantify and compare fractions of activated CD4- and CD8-positive T-lymphocytes, based on the quantity of damaged cells in a given blood sample. Blood samples were mechanically stressed by vortexing intensely. Subsequently, different quantities of distressed blood samples were mixed with samples of fresh, whole blood. Afterwards, the extent of CD4- and CD8-positive T-cell activation was examined in the mixture by flow cytometry. Sine-like curves of T-cell activation were observed for both CD4- (T-helper mediated) and CD8- (cyt…
The effects of rapid weight loss on skeletal muscle in judo athletes
2020
Abstract Objective To observe the effect of rapid weight loss (RWL) methods over 3 days on muscle damage in judokas. Methods Eighteen judokas participated in this crossover study, meaning that judo athletes were subjected to exercise-only phase (4 days) and RWL phase (3 days). Subjects were tested for myoglobin, creatine kinase, aldolase, hemoglobin, and hematocrit values on seven consecutive days. These biomarkers served as indicators of acute muscle damage. Results During the exercise-only phase, no significant changes were observed. Myoglobin (Mb) (p < 0.001), creatine kinase (CK) (p < 0.001) and aldolase (ALD) (p < 0.001) significantly increased only during the RWL phase, as we…
Reproducibility and validity of ambulatory blood pressure monitoring in children.
2002
During the past several years ambulatory blood pressure monitoring (ABPM) has been introduced into the study of hypertension and has become a useful tool in making clinical decisions. The ABPM improves the reproducibility of the estimates of a subject's casual blood pressure (BP) both in normotensive and in hypertensive subjects, independent of age. The advantages of ambulatory BP (ABP) over its office counterpart have been studied in children to observe the relationship between BP measurement and early markers of organ damage. In different groups of subjects that have included normotensives, essential hypertensives, renal transplant recipients, or patients with repair of an aortic coarctat…
The Role of ABPM in Evaluation of Hypertensive Target-Organ Damage
2013
Casual blood pressure measurement has provided the basis for the present knowledge of the potential risk associated with hypertension and has guided patient management for many years. The possibility of carrying out repeated ambulatory blood pressure measurements using automatic or semiautomatic devices allows for the gathering of more representative values of blood pressure and for observing the behavior of blood pressure during both moments of activity as well as rest. Ambulatory blood pressure measurement is now increasingly recognized as being indispensable to the diagnosis and management of hypertension, and it has contributed significantly to our understanding of hypertension. Likewis…
Neprilysin inhibition, endorphin dynamics, and early symptomatic improvement in heart failure: a pilot study
2020
Altres ajuts: This work was supported in part by Fundació La Marató de TV3 (201516-10, 201502-30), Societat Catalana de Cardiologia, "la Caixa" Banking Foundation. Altres ajuts: PERIS/SLT002-16-00234 Sacubitril/valsartan is a first-in-class angiotensin receptor-neprilysin inhibitor developed for the treatment of heart failure with reduced ejection fraction. Its benefits are achieved through the inhibition of neprilysin (NEP) and the specific blockade of the angiotensin receptor AT1. The many peptides metabolized by NEP suggest multifaceted potential consequences of its inhibition. We sought to evaluate the short-term changes in serum endorphin (EP) values and their relation with patients' p…