Search results for "DAMAGE"
showing 10 items of 1289 documents
Survival in extreme dryness and DNA-single-strand breaks.
1992
A wide variety of organisms (the so-called "anhydrobiotes') is able to survive long periods of time in a state of utmost dehydration and can thus survive in extremely dry environments including artificially imposed or space vacuum. Known strategies of survival include the accumulation of certain polyols, especially disaccharides, which help prevent damage to membranes and proteins. Here we report that DNA in vacuum-dried spores is damaged to a very substantial degree by processes leading to DNA strand breaks. Most of these lesions are obviously repaired during germination, but extensive damage to DNA and enzymes after long exposure times (months to years) finally diminish the chances of sur…
Response ofBacillus subtilis spores to dehydration and UV irradiation at extremely low temperatures
1996
Spores of Bacillus subtilis have been exposed to the conditions of extreme dehydration (argon/silica gel; simulated space vacuum) for up to 12 weeks at 298 K and 80 K in the dark. The inactivation has been correlated with the production of DNA-double strand-breaks. The temperature-dependence of the rate constants for inactivation or production of DNA-double strand-breaks is surprisingly low. Controls kept in the frozen state at 250 K for the same period of time showed no sign of deterioration. In another series of experiments the spores have been UV irradiated (253.7 nm) at 298 K, 200 K and 80 K after exposure to dehydrating conditions for 3 days. Fluence-effect relationships for inactivati…
In vitro antioxidant properties, DNA damage protective activity, and xanthine oxidase inhibitory effect of cajaninstilbene acid, a stilbene compound …
2010
The antioxidant properties, DNA damage protective activities, and xanthine oxidase (XOD) inhibitory effect of cajaninstilbene acid (CSA) derived from pigeon pea leaves were studied in the present work. Compared with resveratrol, CSA showed stronger antioxidant properties, DNA damage protective activity, and XOD inhibition activity. The IC(50) values of CSA for superoxide radical scavenging, hydroxyl radical scavenging, nitric oxide scavenging, reducing power, lipid peroxidation, and XOD inhibition were 19.03, 6.36, 39.65, 20.41, 20.58, and 3.62 μM, respectively. CSA possessed good protective activity from oxidative DNA damage. Furthermore, molecular docking indicated that CSA was more poten…
Damage identification by a modified Ant Colony Optimization for not well spaced frequency systems
2011
Recently, it has been shown , that a damage detection strategy based on a proper functional calculated on the analytical signal of the structural dynamical response, consents to identify very low damage level. In this regard, they stressed the efficiency of Hilbert Transform to obtain the analytical response representation that shows more sensitivity for predicting damage with respect to the simple signal response. Then, a damage identification procedure based on the minimization of the difference between theoretical and measured data was proposed with satisfactory results. Unfortunately, this procedure, since the need of use of band pass filter around the natural frequency of the system, f…
Role of Negative Pressure Therapy as Damage Control in Soft Tissue Reconstruction for Open Tibial Fractures.
2017
AbstractThe concept of damage control orthopaedics (DCO) is a strategy that focuses on managing orthopaedic injuries in polytrauma patients who are in an unstable physiological state. The concept of DCO is an extension of damage control surgery or damage limitation surgery (DCS/DLS). Recently, it has become clear that certain patients, following extensive soft tissue trauma, could benefit from the idea of DCS. In the management of severe lower extremity trauma with exposed fracture sites, aggressive early wound excision debridement, early internal fixation, and vascularized wound coverage within a few days after trauma were proposed. A negative-pressure dressing can be easily and rapidly ap…
Principles of Damage Control in the Elderly
2017
A steadily increase of severely injured elderly patients may be expected. Comorbidities are present in the majority of these patients and negatively influence outcome. Blunt trauma is the leading cause of high-energy injuries in the elderly. Motor vehicle accidents, either as driver or as pedestrian hit by a car, and falls from height are the most important mechanisms of polytrauma. The principles of advanced trauma life support (ATLS) should also apply for elderly persons. Underestimation of the severity of injury is a common problem leading to undertriage. A basic rule of primary care is to avoid the lethal triad of hypothermia, coagulopathy and acidosis. Emergent invasive monitoring redu…
Towards Low-Cost Pavement Condition Health Monitoring and Analysis Using Deep Learning
2020
Governments are faced with countless challenges to maintain conditions of road networks. This is due to financial and physical resource deficiencies of road authorities. Therefore, low-cost automated systems are sought after to alleviate these issues and deliver adequate road conditions for citizens. There have been several attempts at creating such systems and integrating them within Pavement management systems. This paper utilizes replicable deep learning techniques to carry out hotspot analyses on urban road networks highlighting important pavement distress types and associated severities. Following this, analyses were performed illustrating how the hotspot analysis can be carried out to…
Condition Monitoring Technologies for Synthetic Fiber Ropes - a Review
2020
This paper presents a review of different condition monitoring technologies for fiber ropes. Specifically, it presents an overview of the articles and patents on the subject, ranging from the early 70’s up until today with the state of the art. Experimental results are also included and discussed in a conditionmonitoring context,where failuremechanisms and changes in physical parameters give improved insight into the degradation process of fiber ropes. From this review, it is found that automatic width measurement has received surprisingly little attention, and might be a future direction for the development of a continuous condition monitoring system for synthetic fiber ropes.
Machine learning at the interface of structural health monitoring and non-destructive evaluation
2020
While both non-destructive evaluation (NDE) and structural health monitoring (SHM) share the objective of damage detection and identification in structures, they are distinct in many respects. This paper will discuss the differences and commonalities and consider ultrasonic/guided-wave inspection as a technology at the interface of the two methodologies. It will discuss how data-based/machine learning analysis provides a powerful approach to ultrasonic NDE/SHM in terms of the available algorithms, and more generally, how different techniques can accommodate the very substantial quantities of data that are provided by modern monitoring campaigns. Several machine learning methods will be illu…
A Boundary Element Formulation for Modelling Structural Health Monitoring Applications
2015
In this paper, a boundary element formulation for modelling pitch-catch damage detection applications is introduced. The current formulation has been validated by both finite element analyses and physical experiments. Comparing to the widely used finite element method, the current formulation does not only use less computational resources, but also demonstrates higher numerical stability. doi: 10.12783/SHM2015/221