Search results for "DAP"

showing 10 items of 3579 documents

Natural Selection Fails to Optimize Mutation Rates for Long-Term Adaptation on Rugged Fitness Landscapes

2008

The rate of mutation is central to evolution. Mutations are required for adaptation, yet most mutations with phenotypic effects are deleterious. As a consequence, the mutation rate that maximizes adaptation will be some intermediate value. Here, we used digital organisms to investigate the ability of natural selection to adjust and optimize mutation rates. We assessed the optimal mutation rate by empirically determining what mutation rate produced the highest rate of adaptation. Then, we allowed mutation rates to evolve, and we evaluated the proximity to the optimum. Although we chose conditions favorable for mutation rate optimization, the evolved rates were invariably far below the optimu…

0106 biological sciencesMutation rateTime FactorsDigital organismsFitness landscapeQH301-705.5Biology010603 evolutionary biology01 natural sciencesCellular and Molecular Neuroscience03 medical and health sciences0302 clinical medicineGeneticsComputer SimulationBiology (General)Selection GeneticMolecular BiologyEcology Evolution Behavior and Systematics030304 developmental biology0303 health sciencesEvolutionary BiologyNatural selectionEcologyModels GeneticComputational Biology15. Life on landAdaptation PhysiologicalBiological EvolutionComputational Biology/Evolutionary ModelingReplication fidelityAsexual populationsEvolvabilityComputational Theory and MathematicsEvolutionary biologyModeling and SimulationViral evolutionMutation (genetic algorithm)MutationDNA Mismatch repairAdaptationAvida030217 neurology & neurosurgeryResearch Article
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Trans-generational immune priming is constrained by the maternal immune response in an insect.

2012

5 pages; International audience; Immune-challenged vertebrate and invertebrate females can transfer immunity to their off spring. Th is trans-generational immune priming (TGIP) is benefi cial for the off spring if the maternal infection risk persists across generations. However, because immunity is costly, fi tness consequences of TGIP have been found in primed off spring. Furthermore, transferring immunity to off spring may be costly for immune-challenged females who are also carrying the costs of their immune response. A negative relationship between levels of immunity between mothers and off spring might therefore be expected. Consistent with this hypothesis, we show that in the insect, …

0106 biological sciencesOffspringmedia_common.quotation_subjectanimal diseaseschemical and pharmacologic phenomenaInsectBiologyBody size[ SDV.IMM.IA ] Life Sciences [q-bio]/Immunology/Adaptive immunology010603 evolutionary biology01 natural sciences03 medical and health sciencesTrans generationalImmune systemImmunity[ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology environment/SymbiosisEcology Evolution Behavior and Systematics030304 developmental biologymedia_common[ SDE.BE ] Environmental Sciences/Biodiversity and Ecology0303 health sciencesbiochemical phenomena metabolism and nutritionMaternal infection[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunologyImmunologybacteria[SDE.BE]Environmental Sciences/Biodiversity and EcologyPriming (psychology)[SDV.EE.IEO]Life Sciences [q-bio]/Ecology environment/Symbiosis
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Spatiotemporal Structure of Host‐Pathogen Interactions in a Metapopulation

2009

International audience; The ecological and evolutionary dynamics of species are influenced by spatiotemporal variation in population size. Unfortunately, we are usually limited in our ability to investigate the numerical dynamics of natural populations across large spatial scales and over long periods of time. Here we combine mechanistic and statistical approaches to reconstruct continuous-time infection dynamics of an obligate fungal pathogen on the basis of discrete-time occurrence data. The pathogen, Podosphaera plantaginis, infects its host plant, Plantago lanceolata, in a metapopulation setting where the presence of the pathogen has been recorded annually for 6 years in similar to 4,00…

0106 biological sciencesPODOSPHAERA PLANTAGINISMetapopulationRELATION PLANTE-PATHOGENEBiologyENCOUNTER RATE010603 evolutionary biology01 natural sciences03 medical and health sciencesAscomycotaHOST-PARASITE INTERACTIONAnimals[INFO]Computer Science [cs]MECHANISTIC-STATISTICAL MODEL[MATH]Mathematics [math]Evolutionary dynamicsPlantagoFinlandEcology Evolution Behavior and SystematicsOverwinteringCoevolutionPlant Diseases030304 developmental biologyLocal adaptation0303 health sciencesObligateHost (biology)EcologyCOEVOLUTIONPopulation sizeBiological EvolutionSURVIVAL PROBABILITYTEMPORAL STABILITYPLANTAGO LANCELOLATAHost-Pathogen InteractionsSeasonsAlgorithmsThe American Naturalist
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Breeding success of the Great Tit Parus major in relation to attributes of natural nest cavities in a primeval forest

2015

An overlap in attributes of nest cavities used by Great Tit Parus major across Eurasia suggests similar nest site preferences within the geographical range, although the drivers of these preferences are unclear. To determine whether preferred cavities provide conditions enhancing successful reproduction, we investigated the breeding performance of Great Tits in relation to tree cavity characteristics using data collected during 2008–2011 in primeval conditions (Białowieża National Park, Poland). Here, tree cavities are diverse and superabundant but nesting birds are at risk from a variety of predators. According to expectations, nest losses were high (60 % of Great Tit nests failed), mostly…

0106 biological sciencesParusAvian clutch sizegeographygeography.geographical_feature_categorybiologyDryomys nitedulaEcologyOld-growth forestbiology.organism_classification010603 evolutionary biology01 natural sciencesEcology and Environment010605 ornithologyPredationNestbiology.animalTree cavities Nest site selection Adaptations Nest predation Clutch size Białowieża National ParkDormouseZoologyNest boxJournal of Ornithology
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Measuring phenotypes in fluctuating environments

2020

Despite considerable theoretical interest in how the evolution of phenotypic plasticity should be shaped by environmental variability and stochasticity, how individuals actually respond to these aspects of the environment within their own lifetimes remains unclear. We propose that this understanding has been hampered by experimental approaches that expose organisms to fluctuating environments (typically treatments where fluctuations in the environment are cyclical vs. erratic) for a pre‐determined duration while ensuring that the mean environment over that the entire exposure period is invariable. This approach implicitly assumes that responses to the mean and variance/predictability in the…

0106 biological sciencesPhenotypic plasticitybiologyfungiConfoundingDaphnia magnabiology.organism_classification010603 evolutionary biology01 natural sciencesDaphniaHeat toleranceEnvironment variableStatisticsPredictabilityMean radiant temperatureEcology Evolution Behavior and Systematics010606 plant biology & botanyFunctional Ecology
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Selection for reproduction under short photoperiods changes diapause-associated traits and induces widespread genomic divergence.

2019

The work has been supported by the Academyof Finland to A.H. (project 267244) and Natural Environment Research Council (NERC) funding (NE/J020818/1 to M.G.R.; NE/L501852/1 to R.A.W.W.). The incidence of reproductive diapause is a critical aspect of life history in overwintering insects from temperate regions. Much has been learned about the timing, physiology and genetics of diapause in a range of insects, but how the multiple changes involved in this and other photoperiodically regulated traits are inter-related is not well understood. We performed quasinatural selection on reproduction under short photoperiods in a northern fly species, Drosophila montana, to trace the effects of photoper…

0106 biological sciencesPhysiology030310 physiologyQH301 BiologyCircadian clockGenome Insect01 natural sciencestalvehtiminenkylmänkestävyyscircadian clockmedia_commonvuorokausirytmi0303 health sciencesluonnonvalintagenome analysesReproductionPhenotypeAdaptation PhysiologicalCircadian RhythmCold TemperatureDrosophila melanogasterPhenotypeFemaleReproductionLocomotionendocrine systemmahlakärpäsetPeriod (gene)media_common.quotation_subjectPhotoperiodZoologyreproductive diapausefotobiologiaAquatic ScienceDiapauseBiology010603 evolutionary biology03 medical and health sciencesQH301Quantitative Trait Heritablephotoperiodic timerAnimalsCircadian rhythmMolecular BiologyGeneEcology Evolution Behavior and SystematicsSelection (genetic algorithm)Critical day lenghtGenetic VariationDAScold tolerancelisääntyminenDiapauseChromosomes Insectcritical day lengthInsect ScienceperimähyönteisetLinear ModelsAnimal Science and ZoologyThe Journal of experimental biology
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Membrane glycerolipid remodeling triggered by nitrogen and phosphorus starvation in Phaeodactylum tricornutum.

2014

International audience; Diatoms constitute a major phylum of phytoplankton biodiversity in ocean water and freshwater ecosystems. They are known to respond to some chemical variations of the environment by the accumulation of triacylglycerol, but the relative changes occurring in membrane glycerolipids have not yet been studied. Our goal was first to define a reference for the glycerolipidome of the marine model diatom Phaeodactylum tricornutum, a necessary prerequisite to characterize and dissect the lipid metabolic routes that are orchestrated and regulated to build up each subcellular membrane compartment. By combining multiple analytical techniques, we determined the glycerolipid profil…

0106 biological sciencesPhysiologyPlant ScienceThylakoids01 natural sciencesPhaeodactylum tricornutumTranscriptomeMGDGNutrientnutrient starvationLipids metabolismSettore BIO/04 - Fisiologia VegetaleDigalactosyldiacylglycerolPhospholipids0303 health sciencesbiologyNitrogen starvationmicroalgaeMonogalactosyldiacyglycerolPhosphorusArticlesAdaptation PhysiologicalBiochemistryThylakoidSulfoquinovosyldiacylglycerollipids (amino acids peptides and proteins)DGDGNitrogenchemistry.chemical_elementlipidsMembrane Lipids03 medical and health sciencesSQDG[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyGenetics[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology14. Life underwaterPhaeodactylum tricornutumTriglycerides030304 developmental biologyDiatomsMembranesGene Expression ProfilingPhosphorusfungiPhosphorus starvationGlycerolipidsLipid metabolismmetabolic pathwaybiology.organism_classificationMetabolic pathwayPhosphatidylcholineDiatomchemistryPhytoplanktonLipidomics010606 plant biology & botany
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Immune response affects ant trophallactic behaviour.

2008

5 pages; International audience; Sociality is associated with many benefits that have favoured its evolution in social insects. However, sociability also presents disadvantages like crowding of large numbers of individuals, which may favour the spread of infections within colonies. Adaptations allowing social insects to prevent and/or control pathogen infections range from behavioural responses to physiological ones including their immune systems. In a state of infection, social interactions with nestmates should be altered in a way which might prevent its spreading. We simulated a microbial infection in workers of the ant Camponotus fellah by the administration of peptidoglycan (PGN) and t…

0106 biological sciencesPhysiology[ SDV.BA.ZI ] Life Sciences [q-bio]/Animal biology/Invertebrate ZoologyAdaptation BiologicalPeptidoglycanBiologySocial interactions010603 evolutionary biology01 natural sciencesAntibacterial peptidesLife history theory03 medical and health sciencesImmune system[ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology environment/SymbiosisAnimals[ SDV.IMM ] Life Sciences [q-bio]/ImmunologyIsraelImmune responseSocial BehaviorFormicidaeSociality030304 developmental biology0303 health sciencesAnalysis of Variance[ SDE.BE ] Environmental Sciences/Biodiversity and EcologyAntsFeeding BehaviorANTAntibacterial peptide[SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate ZoologyInsect ScienceImmunology[SDV.IMM]Life Sciences [q-bio]/ImmunologyEncapsulation[SDE.BE]Environmental Sciences/Biodiversity and EcologyTrophallaxisTrophallaxisCamponotus fellah[SDV.EE.IEO]Life Sciences [q-bio]/Ecology environment/Symbiosis
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Plasmodium relictum infection and MHC diversity in the house sparrow (Passer domesticus).

2010

Antagonistic coevolution between hosts and parasites has been proposed as a mechanism maintaining genetic diversity in both host and parasite populations. In particular, the high level of genetic diversity usually observed at the major histocompatibility complex (MHC) is generally thought to be maintained by parasite-driven selection. Among the possible ways through which parasites can maintain MHC diversity, diversifying selection has received relatively less attention. This hypothesis is based on the idea that parasites exert spatially variable selection pressures because of heterogeneity in parasite genetic structure, abundance or virulence. Variable selection pressures should select for…

0106 biological sciencesPlasmodium[ SDV.IMM.IA ] Life Sciences [q-bio]/Immunology/Adaptive immunology01 natural sciencessusceptibilityMajor Histocompatibility Complex[ SDE ] Environmental SciencesGene Frequency[ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology environment/SymbiosisResearch ArticlesGeneral Environmental ScienceGenetics0303 health sciencesbiologyPlasmodium relictumGeneral Medicine3. Good health[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunologyGenetic structure[SDE]Environmental Sciencesavian malariaGeneral Agricultural and Biological SciencesSparrowsMalaria AvianAntagonistic CoevolutionMajor histocompatibility complex010603 evolutionary biologyGeneral Biochemistry Genetics and Molecular Biologyresistance03 medical and health sciencesAvian malariamedicinePasser domesticusAnimalsSelection GeneticAllelesSelection (genetic algorithm)030304 developmental biologyLocal adaptationGenetic diversity[ SDE.BE ] Environmental Sciences/Biodiversity and EcologyGeneral Immunology and Microbiologydiversifying selectionbiology.organism_classificationmedicine.diseaseImmunity InnatePlasmodium relictumbiology.protein[SDE.BE]Environmental Sciences/Biodiversity and Ecology[SDV.EE.IEO]Life Sciences [q-bio]/Ecology environment/Symbiosis
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Intergenerational fitness effects of the early life environment in a wild rodent.

2019

The early life environment can have profound, long-lasting effects on an individual's fitness. For example, early life quality might (a) positively associate with fitness (a silver spoon effect), (b) stimulate a predictive adaptive response (by adjusting the phenotype to the quality of the environment to maximize fitness) or (c) be obscured by subsequent plasticity. Potentially, the effects of the early life environment can persist beyond one generation, though the intergenerational plasticity on fitness traits of a subsequent generation is unclear. To study both intra- and intergenerational effects of the early life environment, we exposed a first generation of bank voles to two early life…

0106 biological sciencesPopulation DensityReproductive successOffspringArvicolinae010604 marine biology & hydrobiologyReproductionfungiMaternal effectSocial environmentRodentiaAdaptive responseBiology010603 evolutionary biology01 natural sciencesPopulation densityPredictive adaptive responseTraitAnimalsAnimal Science and ZoologyFemaleSeasonsEcology Evolution Behavior and SystematicsDemographyThe Journal of animal ecologyREFERENCES
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