Search results for "DAP"
showing 10 items of 3579 documents
PLLA scaffolds with controlled architecture as potential microenvironment for in vitro tumor model
2019
Abstract The "microenvironment" where a tumor develops plays a fundamental role in determining its progression, the onset of metastasis and, eventually, its resistance to therapies. Tumor cells can be considered more or less invasive depending both on the nature of the cells and on the site where they are located. Commonly adopted laboratory culture protocols for the investigation of tumor cells take usually place on standard two-dimensional supports. However, such cultures do not allow for reproduction of the biophysical properties of the tumor’s microenvironment, thus causing the cells to lose most of their relevant characteristics. In this work MDA-MB 231 breast cancer cells were cultiva…
Adaptive Number Knowledge in Secondary School Students: Profiles and Antecedents
2019
Cited By :1 Export Date: 10 February 2021 Correspondence Address: McMullen, J.; Department of Teacher EducationFinland; email: jake.mcmullen@utu.fi The present study aims to examine inter-individual differences in adaptive number knowledge in secondary school students. Adaptive number knowledge is defined as a well-connected network of knowledge of numerical characteristics and arithmetic relations. Substantial and relevant qualitative differences in the strategies and expression of adaptive number knowledge have been found in primary school students still in the process of learning arithmetic. We present a study involving 879 seventh-grade students that examines the structure of individual…
On the stability of some controlled Markov chains and its applications to stochastic approximation with Markovian dynamic
2015
We develop a practical approach to establish the stability, that is, the recurrence in a given set, of a large class of controlled Markov chains. These processes arise in various areas of applied science and encompass important numerical methods. We show in particular how individual Lyapunov functions and associated drift conditions for the parametrized family of Markov transition probabilities and the parameter update can be combined to form Lyapunov functions for the joint process, leading to the proof of the desired stability property. Of particular interest is the fact that the approach applies even in situations where the two components of the process present a time-scale separation, w…
Fisiopatología celular del déficit de GDAP1, relacionado con la enfermedad de Charcot-Marie-Tooth
2012
La enfermedad de Charcot-Marie-Tooth es uno de los trastornos neurológicos hereditarios más comunes que afecta aproximadamente a uno de casa 2.500 – 5.000 habitantes. La enfermedad CMT se clasifica en neuropatías desmielinizantes (CMT1) y neuropatías axonales (CMT2). Para ambas entidades se han descrito diversos patrones de herencia. Actualmente se conocen más de 40 genes implicados en la enfermedad siendo GDAP1 uno de los más variables en cuanto al fenotipo. Mutaciones en el gen GDAP1 se han relacionado con la enfermedad de tipo axonal y desmielinizante, además de heredarse de manera autosómica dominante o recesiva en función del tipo de mutación. GDAP1 es una proteína pequeña que se ancla…
Informational, ecological and system approaches for complete genome analysis
2012
In the study of the genetic modifications leading populations to adapt to their environment, it is important to distinguish changes resulting in an increase in biological fiteness from those slightly deleterious. Besides that the concept of neutral changes is defined since the ¿Origin of species¿ by Charles Darwin, its relevance to the overall changes defining evolutionary process was considered to be very low, if existent. But, in the late sixties, with the advances of molecular experiments and the first comparative studies in this field, neutral changes were proven to be almost sufficient to explain the amount of changes per generation observed at molecular level. Based on this observatio…
Respuesta inmune en el infarto agudo de miocardio. Un estudio traslacional
2014
Información experimental y evidencia clínica preliminar sugieren que en el infarto agudo de miocardio (IAM) se produce una pérdida de control del sistema inmune por las células T reguladores (Treg). No existen datos de la relación entre este mecanismo fisiopatológico con el tamaño del infarto. En 100 pacientes consecutivos con un primer IAM con elevación del segmento ST tratados con angioplastia primaria se determinarán (antes de la reperfusión, a las 24, 96 horas y 30 días): (1) Treg CD4+CD25+ (foxp3). (2) Células autoagresivas CD4+CD28null. (3) Linfocitos T helper (Th) Th1 y Th2. (4) Apoptosis linfocitaria. (5) Interleucinas pro- y anti-inflamatorias. Se determinarán estos parámetros en u…
Hacia la ley europea del clima: las evaluaciones científicas y el futuro papel de las respuestas jurídicas de los estados miembros
2021
Los problemas climáticos son temas persistentes y omnipresentes dentro de las políticas y legislaciones contemporáneas, que exigen un enfoque interdisciplinario para promover soluciones jurídicas adecuadas para la complejidad del tema. Paradójicamente, las propagandas negacionistas, lejos de bloquear las acciones climáticas, las han propiciado, lo que ha llevado al establecimiento de un organismo científico super partes que reconociese las cuestiones climáticas a través de informes científicos avanzados: el Grupo Intergubernamental de Expertos sobre el Cambio Climático de la ONU (IPCC). Desde entonces, muchos países han usado los hallazgos del IPCC como base científica para desarrollar polí…
Property and cross-border couples from the perspective of European regulation
2021
The family property regimes constitute a relevant sector of the EU regulatory framework strongly connected with fundamental rights policies. Family property offers specific issues which need to balance individual rights with general interests, especially in matter of real estate property. The fragmentation of the discipline in EU Family law, the diversity of the domestic rules regarding rights in rem requires a large use of flexibility from EU legislator and EU legal professionals. The discipline provides by EU Regulations 1103 and 1104/2016 could be an interesting example to manage cross-border couple?s interests: the principles of universality and unity have to be used appropriately and, …
Evolución de la normativa de la investigación Biomédica en España
2018
The ratification by the Spanish State of the ?Oviedo Convention? in 1999 implies a commitment to adapt to the legislation on biomedicine, since the normative instruments that respect it: guarantee the rights and fundamental freedoms of all and ensure dignity and identity of human beings. The object of this paper is the analysis of the Spanish normative norm in the field of research in human beings.
Gestación subrogada y dignidad de la mujer
2018
The situation of the surrogate pregnancy in Spain demands action by our legislators and / or our public authorities. The reason is that the current legal system in which there is a ban of the surrogacy contract is not being attended. In this issue an analysis of the situation in Spain and in other countries is made, to conclude from the right to the dignity of women, that possible actions could be taken to adapt the reality to the legal system.