Search results for "DAS"
showing 10 items of 4164 documents
Hallazgo de monedas del siglo III en Lequeitio (Vizcaya) en 1803
2010
Durante las obras de la fuente pública de Lequeitio en 1802-1803 se encontraron algunas monedas romanas de las que José Vargas Ponce pudo ver tres en una colección privada de Tolosa. Con los datos proporcionados por el autor es posible identificar el hallazgo como parte de un conjunto monetario del siglo III d.C.
Thermodynamics of the Interaction between the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus-2 and the Receptor of Human Angiotensin-…
2020
Since the end of 2019, the coronavirus SARS-CoV-2 has caused more than 1000000 deaths all over the world and still lacks a medical treatment despite the attention of the whole scientific community. Human angiotensin-converting enzyme 2 (ACE2) was recently recognized as the transmembrane protein that serves as the point of entry of SARS-CoV-2 into cells, thus constituting the first biomolecular event leading to COVID-19 disease. Here, by means of a state-of-the-art computational approach, we propose a rational evaluation of the molecular mechanisms behind the formation of the protein complex. Moreover, the free energy of binding between ACE2 and the active receptor binding domain of the SARS…
Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity? Insights from All-Atom Simulations
2020
The severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic is setting the global health crisis of our time, causing a devastating societal and economic burden. An idiosyncratic trait of coronaviruses is the presence of spike glycoproteins on the viral envelope, which mediate the virus binding to specific host receptor, enabling its entry into the human cells. In spite of the high sequence identity of SARS-CoV-2 with its closely related SARS-CoV emerged in 2002, the atomic-level determinants underlining the molecular recognition of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) receptor and, thus, the rapid virus spread into human body, remain unresolved. Here, multi-m…
Lehrsätze über den Gebrauch der Pronomina reflexiva der lettischen Sprache
1830
Bibliogrāfiskās ziņas: Seniespiedumi latviešu valodā, 1525-1855 : kopkatalogs. Rīga : Latvijas Nacionālā bibliotēka, 1999, Nr. 1279. Pieejams arī tiešsaistē: seniespiedumi_latviesu_valoda_1525_1855.pdf
Lettische Grammatik
1783
Zweite Auflage.
Formenlehre der lettischen Sprache
1878
Effect of imidazo[1,2-α]pyrimidine derivatives on leukocyte function
2001
Objective and Design: A series of six imidazo[1,2-α]pyrimidine (IP) derivatives were evaluated for their effects on leukocyte functions in vitro as well as on the inflammatory response induced by zymosan in the mouse air pouch.¶Materials and Subjects: Human neutrophils and murine peritoneal macrophages were used for in vitro assays. Mouse air pouch was performed in Swiss mice.¶Treatment: Test compounds were incubated with either human neutrophils or mouse peritoneal macrophages at concentrations not showing cytotoxic effects. For in vivo experiments, IPs were injected into the air pouch.¶Methods: Elastase and myeloperoxidase release, superoxide generation and LTB4 production were assayed in…
Effects of caffeoyl conjugates of isoprenyl-hydroquinone glucoside and quinic acid on leukocyte function.
2002
The activity of three prenylhydroquinone glucosides (1-3) and four caffeoylquinic esters (4-7), obtained from Phagnalon rupestre, on elastase release, myeloperoxidase activity and superoxide and leukotriene B(4) production from polymorphonuclear leukocytes was determined. 4,5-Dicaffeoylquinic acid strongly inhibited elastase release with an IC(50) value of 4.8 microM. Methylated caffeoylquinic derivatives were the most potent inhibitors of myeloperoxidase (IC(50) near 60 microM), whereas both methylated and free carboxyl isomers inhibited superoxide production with similar potency (IC(50) between 27 and 42 microM). The monocaffeoyl conjugate of prenylhydroquinone glucoside (3), the most pot…
HSP27 controls GATA-1 protein level during erythroid cell differentiation.
2010
AbstractHeat shock protein 27 (HSP27) is a chaperone whose cellular expression increases in response to various stresses and protects the cell either by inhibiting apoptotic cell death or by promoting the ubiquitination and proteasomal degradation of specific proteins. Here, we show that globin transcription factor 1 (GATA-1) is a client protein of HSP27. In 2 models of erythroid differentiation; that is, in the human erythroleukemia cell line, K562 induced to differentiate into erythroid cells on hemin exposure and CD34+ human cells ex vivo driven to erythroid differentiation in liquid culture, depletion of HSP27 provokes an accumulation of GATA-1 and impairs terminal maturation. More spec…
Leksinių samplaikų sąrašo tikslinimas: bandymas taikyti "Formulex" metodą
2016
Svetimkalbių vartotojų produkuojamos kalbos tekstynai pastaruoju metu neretai tiriami aprašant leksines samplaikas, t. y. pasikartojančias tam tikro ilgio žodžių sekas, jų vartojimą bei funkcijas. Tokiuose tyrimuose neišvengiamai susiduriama su iš dalies sutampančiomis ar nepilnos struktūros samplaikomis. Pavyzdžiui, keturžodės anglų kalbos samplaikos at the same time, the same time it ir but at the same yra automatiškai generuojamos kompiuterio programa kaip tekstyne pasikartojančios sekos. Tačiau ar kiekviena jų laikytina tikrąja samplaika? Ar kiekvienai iš jų galima priskirti vienokią ar kitokią funkciją? Šiame straipsnyje siekiama parodyti, kaip „Formulex” metodas (Forsyth, 2015a, 2015b…