Search results for "DAS"

Pisa syndrome after rasagiline therapy in a patient with Parkinson’s disease

2015

Dear Editor, We have read with interest comments by Solla et al. [1] regarding our Letter to the Editor published in NeurologicalSciences titled ‘‘Insidious onset of Pisa Syndrome afterrasagiline therapy in a patient with Parkinson’s Disease’’[2]. We thank the authors for their interest in our paper, but we think it is necessary to make some clarifications regarding the temporal relationship between the onset of Pisa Syndrome (PS) and rasagiline therapy. PS occurred in fact after and not before rasagiline treatment as stated by Solla et al. In particular, PS occurred after a time interval of 6–12 months and anyway after rasagiline was added to patient’s therapy. This long time interval is o…

Differentiation of Penicillium griseofulvum Dierckx isolates by enzyme assays and by patulin and griseofulvin analyses

1990

The production of patulin and griseofulvin by 49 different isolates of Penicillium griseofulvum Dierckx was analyzed by high-performance liquid chromatography. Eleven isolates were obtained from pistachio nuts, 37 were obtained from wheat seeds, and 1 was obtained from the American Type Culture Collection. Activities of 19 enzymes were also assayed by the API ZYM system. From these results it may be deduced that there are two different groups among the strains tested which cannot be distinguished by morphological and cultural characteristics. One group of isolates did not produce detectable amounts of patulin and griseofulvin when grown in sucrose-yeast extract and Wickerham media, while en…

El Mediterráneo o la creatividad

2001

El G-8 y las Naciones Unidas

2001

La industria exógena en la periferia occidental del área metropolitana de Valencia (A.M.V.)

1991

En el tejido industrial de las comarcas occidentales del A. M. V., el Camp de Túria y la Hoya de Buñol-Chiva, hallamos una dualismo respecto al origen de los establecimientos industriales ubicados en ambas comarcas: la industria autóctona y la actividad fabril foránea. Tras analizar los factores que condicionan la localización de estas industrias exógenas definiremos qué rasgos las caracterizan así como el nivel de integración con respecto al espacio que las acoge. En la industria foránea hemos diferenciado aquellos establecimientos industriales que se han instalado tras un traslado de aquéllos otros de nueva creación producto de la iniciativa foránea

Structure, mechanism and regulation of peroxiredoxins.

2003

Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels which mediate signal transduction in mammalian cells. Prxs can be regulated by changes to phosphorylation, redox and possibly oligomerization states. Prxs are divided into three classes: typical 2-Cys Prxs; atypical 2-Cys Prxs; and 1-Cys Prxs. All Prxs share the same basic catalytic mechanism, in which an active-site cysteine (the peroxidatic cysteine) is oxidized to a sulfenic acid by the peroxide substrate. The recycling of the sulfenic acid back to a thiol is what distinguishes the three enzyme classes. Using crystal structures, a detailed catalytic cycle has been deriv…

Phosphorylation of peroxisome proliferator-activated receptor α in rat Fao cells and stimulation by ciprofibrate

1999

The basic mechanism(s) by which peroxisome proliferators activate peroxisome proliferator-activated receptors (PPARs) is (are) not yet fully understood. Given the diversity of peroxisome proliferators, several hypotheses of activation have been proposed. Among them is the notion that peroxisome proliferators could activate PPARs by changing their phosphorylation status. In fact, it is well known that several members of the nuclear hormone receptor superfamily are regulated by phosphorylation. In this report, we show that the rat Fao hepatic-derived cell line, known to respond to peroxisome proliferators, exhibited a high content of PPARalpha. Alkaline phosphatase treatment of Fao cell lysat…

Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated re…

2015

In patients with sepsis, liver metabolism and its capacity to provide other organs with energetic substrates are impaired. This and many other pathophysiological changes seen in human patients are reproduced in mice injected with purified endotoxin (lipopolysaccharide, LPS). In the present study, down-regulation of genes involved in hepatic fatty acid oxidation (FAOx) and gluconeogenesis in mice exposed to LPS was challenged by nutritional intervention with Argan oil. Mice given a standard chow supplemented or not with either 6% (w/w) Argan oil (AO) or 6% (w/w) olive oil (OO) prior to exposure to LPS were explored for liver gene expressions assessed by mRNA transcript levels and/or enzyme a…

La storia del gatto con gli stivali

2011

Durante años, los cuentos de hadas han sido contados por diferentes narradores sin necesidad de tener ningún derecho público. Diferentes narradores han contado a menudo historias similares sin problemas de plagios, y solo unos pocos han alcanzado el privilegio de firmar sus historias. La consecuencia de este hecho es que muchos de los cuentos de hadas son  colecciones anónimas de tramas combinadas por la autoridad del género. Desde este punto de vista, los cuentos acaban siendo una especie de colección de coincidencias entre autores que defienden su derecho a contar “La verdadera historia” o “La historia de las historias”. Por lo tanto, podemos definir estos cuentos como un conjunto de auto…

Descartes on Corporeal Substances

2015

I defend in this paper the following two theses: first, that Descartes was a Pluralist as regards extended substances, that is, that for him the extended world includes a plurality of bodies, including ordinary objects, each of which may be adequately described as a substance; and that for him the notion of substance is a rather slim notion, making no specific requirements as regards individuation or persistence conditions, and determining therefore no strict constraints on the kind of material objects that may count as substances. In short, I will be arguing for a certain view concerning the extension of the phrase ‘extended substance’ by defending a specific view of what ‘substance’ means…