Search results for "DAS"
showing 10 items of 4164 documents
NADH dehydrogenase deficiency results in low respiration rate and improved aerobic growth of Zymomonas mobilis.
2008
The respiratory chain of the ethanol-producing bacterium Zymomonas mobilis is able to oxidize both species of nicotinamide cofactors, NADH and NADPH. A mutant strain with a chloramphenicol-resistance determinant inserted in ndh (encoding an NADH : CoQ oxidoreductase of type II) lacked the membrane NADH and NADPH oxidase activities, while its respiratory d-lactate oxidase activity was increased. Cells of the mutant strain showed a very low respiration rate with glucose and no respiration with ethanol. The aerobic growth rate of the mutant was elevated; exponential growth persisted longer, resulting in higher biomass densities. For the parent strain a similar effect of aerobic growth stimulat…
Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen
2003
Although room air is adequate for resuscitating asphyxiated newborn infants, guidelines recommend using 100% oxygen. Hyperoxemia, as has been noted in animal studies, could cause delayed breathing, increased oxygen consumption, and disordered cerebral circulation. In addition, 100% oxygen has caused prolonged oxidation of blood glutathione in neonates. In this study, 51 asphyxiated neonates born at term were randomly assigned to resuscitation with room air (RAR) and 55 to resuscitation with 100% oxygen (OxR). The goal was to learn whether using oxygen for resuscitation triggers oxidative stress. Critical criteria were the Apgar score, the time of the first cry, and sustained respiration. Si…
Short-Time Ocular Ischemia Induces Vascular Endothelial Dysfunction and Ganglion Cell Loss in the Pig Retina
2019
Visual impairment and blindness are often caused by retinal ischemia-reperfusion (I/R) injury. We aimed to characterize a new model of I/R in pigs, in which the intraocular pathways were not manipulated by invasive methods on the ocular system. After 12 min of ischemia followed by 20 h of reperfusion, reactivity of retinal arterioles was measured in vitro by video microscopy. Dihydroethidium (DHE) staining, qPCR, immunohistochemistry, quantification of neurons in the retinal ganglion cell layer, and histological examination was performed. Retinal arterioles of I/R-treated pigs displayed marked attenuation in response to the endothelium-dependent vasodilator, bradykinin, compared to sham-tre…
El pintor Daniel Cortina Mestre. Noves aportacions sobre la seua obra: el "Retrat de María Godina de Bellveser"
2003
De Daniel Cortina Mestre, pintor nacido en Valencia, se tienen escasos datos sobre su vida y obra. El presente artículo es una aportación en dicho sentido a partir del Retrato de María Godina de Bellveser, obra inédita suya que pertenece a una colección particular. A partir de esta obra, se aportan nuevos datos sobre la vida y formación de su autor, y se analiza su relación con el concepto de retrato vigente en aquel momento. (A)
Pathogenesis and molecular mechanisms of anderson–fabry disease and possible new molecular addressed therapeutic strategies
2021
Anderson–Fabry disease (AFD) is a rare disease with an incidenceof approximately 1:117,000 male births. Lysosomal accumulation of globotriaosylceramide (Gb3) is the element characterizing Fabry disease due to a hereditary deficiency α-galactosidase A (GLA) enzyme. The accumulation of Gb3 causes lysosomal dysfunction that compromises cell signaling pathways. Deposition of sphingolipids occurs in the autonomic nervous system, dorsal root ganglia, kidney epithelial cells, vascular system cells, and myocardial cells, resulting in organ failure. This manuscript will review the molecular pathogenetic pathways involved in Anderson–Fabry disease and in its organ damage. Some studies reported that i…
Biotic recovery after the end-Triassic extinction event: Evidence from marine bivalves of the Neuquén Basin, Argentina
2017
We analyze the Late Triassic extinction and Early Jurassic recovery of bivalve faunas within marine environments in the Atuel River area of the Neuquén Basin, Argentina. Data were collected from a hundred samples with invertebrates in a well-exposed uppermost Triassic to lower Jurassic section in the Neuquén Basin (southern Mendoza Province, Argentina) and allow a high-resolution reconstruction of the local diversity dynamics. The nearly continuous presence of marine stenohaline major taxa such as cnidarians, rhynchonelliform brachiopods, echinoderms and cephalopods indicates normal salinity throughout. All bivalve species were identified, and each occurrence was recorded in meters above th…
Prevalencias de exposición a riesgos laborales en trabajadoras embarazadas (proyecto INMA-Valencia)
2009
Objetivo: Describir las prevalencias de exposición declarada a riesgos laborales en mujeres embarazas y analizar su relación con características sociodemográficas y laborales a partir de la información recogida en la cohorte INMA-Valencia. Métodos: La cohorte INMA-Valencia se inicia en 2004 con 855 mujeres embarazadas residentes en la provincia de Valencia. En la semana 32 de gestación se recogió información, mediante entrevista personal con cuestionario estructurado, sobre características sociodemográficas (edad, nivel de estudios, país de nacimiento), condiciones de empleo (actividad, ocupación, tipo de contrato, tipo de jornada) y exposición laboral autorreferida a carga física y riesgos…
Prevalencias de exposición a riesgos laborales en trabajadoras embarazadas (proyecto INMA-Valencia)
2009
ResumenObjetivoDescribir las prevalencias de exposición declarada a riesgos laborales en mujeres embarazas y analizar su relación con características sociodemográficas y laborales a partir de la información recogida en la cohorte INMA-Valencia.MétodosLa cohorte INMA-Valencia se inicia en 2004 con 855 mujeres embarazadas residentes en la provincia de Valencia. En la semana 32 de gestación se recogió información, mediante entrevista personal con cuestionario estructurado, sobre características sociodemográficas (edad, nivel de estudios, país de nacimiento), condiciones de empleo (actividad, ocupación, tipo de contrato, tipo de jornada) y exposición laboral autorreferida a carga física y riesg…
Prevalencias de exposición a riesgos laborales en trabajadoras embarazadas (proyecto INMA-Valencia) Prevalence of exposure to occupational risks in p…
2009
Objetivo: Describir las prevalencias de exposición declarada a riesgos laborales en mujeres embarazas y analizar su relación con características sociodemográficas y laborales a partir de la información recogida en la cohorte INMA-Valencia. Métodos: La cohorte INMA-Valencia se inicia en 2004 con 855 mujeres embarazadas residentes en la provincia de Valencia. En la semana 32 de gestación se recogió información, mediante entrevista personal con cuestionario estructurado, sobre características sociodemográficas (edad, nivel de estudios, país de nacimiento), condiciones de empleo (actividad, ocupación, tipo de contrato, tipo de jornada) y exposición laboral autorreferida a carga física y riesgos…
Oxidative stress in cardiovascular disease: successful translation from bench to bedside?
2007
Over the last decades, sound evidence has been generated that oxidative stress is one of the most potent inductors of endothelial dysfunction and is involved at all stages of atherosclerotic plaque evolution.1,2 Experimental and animal models provide a clear association between the amount of oxidative challenge and reversible vascular dysfunction that can be observed before permanent alterations of the vessel wall occur. Article p 1367 Important for cardiovascular biology is the consumption of nitric oxide (NO) by reactive oxygen species. Endothelium relaxant factor is a central molecule in vascular homeostasis as a modulator of endothelial tone and reactivity.3 It is produced by NO synthas…