Short-Time Ocular Ischemia Induces Vascular Endothelial Dysfunction and Ganglion Cell Loss in the Pig Retina

6533b821fe1ef96bd127b9f4

RESEARCH PRODUCT

Short-Time Ocular Ischemia Induces Vascular Endothelial Dysfunction and Ganglion Cell Loss in the Pig Retina

Ning Xia Huige Li Jenia Kouchek Zadeh Andreas Garcia-bardon Norbert Pfeiffer Marion Ludwig Adrian Gericke Wael Omran Andreas Patzak Erik K. Hartmann

subject

Retinal Ganglion Cells Vascular Endothelial Growth Factor A 0301 basic medicine Pathology Swine Nitric Oxide Synthase Type II Vasodilation endothelial dysfunction lcsh:Chemistry chemistry.chemical_compound 0302 clinical medicine Ischemia Endothelial dysfunction lcsh:QH301-705.5 Spectroscopy General Medicine Computer Science Applications Arterioles medicine.anatomical_structure Retinal ganglion cell Reperfusion Injury NADPH Oxidase 2 medicine.medical_specialty Endothelium Retinal Artery I/R injury Ischemia retinal arterioles Bradykinin Retinal ganglion Retina Article Catalysis ganglion cell loss Inorganic Chemistry 03 medical and health sciences medicine Animals Physical and Theoretical Chemistry Molecular Biology Retina business.industry Organic Chemistry Retinal Hypoxia-Inducible Factor 1 alpha Subunit medicine.disease 030104 developmental biology lcsh:Biology (General)lcsh:QD1-999 chemistry 030221 ophthalmology & optometry Endothelium Vascular Reactive Oxygen Species business

description

Visual impairment and blindness are often caused by retinal ischemia-reperfusion (I/R) injury. We aimed to characterize a new model of I/R in pigs, in which the intraocular pathways were not manipulated by invasive methods on the ocular system. After 12 min of ischemia followed by 20 h of reperfusion, reactivity of retinal arterioles was measured in vitro by video microscopy. Dihydroethidium (DHE) staining, qPCR, immunohistochemistry, quantification of neurons in the retinal ganglion cell layer, and histological examination was performed. Retinal arterioles of I/R-treated pigs displayed marked attenuation in response to the endothelium-dependent vasodilator, bradykinin, compared to sham-treated pigs. DHE staining intensity and messenger RNA levels for HIF-1&alpha

year	journal	country	edition	language
2019-09-21	International Journal of Molecular Sciences

10.3390/ijms20194685 http://dx.doi.org/10.3390/ijms20194685

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