Search results for "DAS"
showing 10 items of 4164 documents
Superoxide Flux in Endothelial Cells via the Chloride Channel-3 Mediates Intracellular Signaling
2007
Reactive oxygen species (ROS) have been implicated in both cell signaling and pathology. A major source of ROS in endothelial cells is NADPH oxidase, which generates superoxide (O2.−) on the extracellular side of the plasma membrane but can result in intracellular signaling. To study possible transmembrane flux of O2.−, pulmonary microvascular endothelial cells were preloaded with the O2.−-sensitive fluorophore hydroethidine (HE). Application of an extracellular bolus of O2.−resulted in rapid and concentration-dependent transient HE oxidation that was followed by a progressive and nonreversible increase in nuclear HE fluorescence. These fluorescence changes were inhibited by superoxide dism…
Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine.
2004
Four phenanthrene and one aporphine alkaloids semi-synthesized from boldine were evaluated for their inhibitory effect on reactive oxygen species (ROS) generation. ROS generation by neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine was inhibited in a concentration dependent manner. Alkaloids exerted similar inhibitory effect in the hypoxanthine-xanthine oxidase system than in stimulated neutrophils, which could be attributed to a direct ROS scavenging activity. None of the alkaloids assayed had any effect on xanthine oxidase activity. Therefore the synthesized alkaloids might constitute an alternative therapy in inflammation disorders in which ROS generation is involved.
Involvement of acyl coenzyme A oxidase isozymes in biotransformation of methyl ricinoleate into gamma-decalactone by Yarrowia lipolytica.
2000
ABSTRACT We reported previously on the function of acyl coenzyme A (acyl-CoA) oxidase isozymes in the yeast Yarrowia lipolytica by investigating strains disrupted in one or several acyl-CoA oxidase-encoding genes ( POX1 through POX5 ) (H. Wang et al., J. Bacteriol. 181:5140–5148, 1999). Here, these mutants were studied for lactone production. Monodisrupted strains produced similar levels of lactone as the wild-type strain (50 mg/liter) except for Δ pox3 , which produced 220 mg of γ-decalactone per liter after 24 h. The Δ pox2 Δpox3 double-disrupted strain, although slightly affected in growth, produced about 150 mg of lactone per liter, indicating that Aox2p was not essential for the biotra…
Aprendizaje basado en proyectos para el desarrollo de las competencias profesionales del maestro: una propuesta de innovación docente desde la Didáct…
2015
Producción Científica
Ḥurūf al-tāǧ wa-ʻalāmāt al-tarqīm wa-mawāḍiʻ istiʻmāluhā
1931
"Kroņa raksts un pieturzīmes un to novietojums" - par arābu valodas ortogrāfijas reformu (lielo burtu izmantošanas ieviešanai un pieturzīmju lietošanas sakārtošanai). Ārējos informācijas avotos minēts arī ar nosaukumu angļu valodā "Crown letters and punctuation and their placements."
Epigrafía árabe del Emirato (siglo IX). Lápida de Tudela y estela de una omeya
2018
Repaso de la epigrafía del emirato y del protocolo de sus epitafios, con edición, traducción y estudio de dos piezas labradas con escritura árabe de estilo cúfico «arcaico». Una lápida se halló, fuera de contexto, en excavaciones practicadas junto a la catedral de Tudela; la otra es el epitafio de una dama Omeya descubierto antes de 1960, sin duda en la ciudad de Córdoba. Estas lápidas emirales se incorporan a la treintena de inscripciones conocidas del siglo IX en la Península Ibérica. 
 
 
 
 
Ģeogrāfisko informācijas sistēmu apguve pamatskolā: Arcgis online praktiskie uzdevumi ģeogrāfijā 7.-9. klasēs
2022
Bakalaura darba tēma ir “Ģeogrāfisko informācijas sistēmu apguve pamatskolā: ArcGIS Online praktiskie uzdevumi ģeogrāfijā 7.-9.klasēs”. Ģeogrāfiskā izglītība visā pasaulē mainās, pēdējā laikā skolās aktīvāk sāka pielietot ģeogrāfiskās informācijas sistēmas (ĢIS) ģeogrāfijas stundās. Arī Latvijā kopš kompetenču pieejas ieviešanu visos mācību priekšmetos, par ģeogrāfijas mācību satura neatņemamo daļu kļuva tiešsaistes ĢIS vide ArcGIS Online, kas ļauj skolēniem izmantot interaktīvās kartes. Ņemot vērā to, ka darbs ar interaktīvām kartēm ir jaunums Latvijas skolās un materiālu daudzums nav pietiekams, bakalaura darba ietvaros tika izvirzīts mērķis - izstrādāt praktiskos uzdevumus ArcGIS Online …
Carp’s-tongue swords - morphological, metallurgical and cultural aspects
2010
This contribution discusses the results from a study of the spatial distribution of different morphological sub-groups of carp’s-tongue swords at a European scale, relating morphological types to the metallurgial make-up of the respective pieces. From this study some surprising conclusions concerning the chronological as well as the spatial dimension of the evolution of carp’s-tongue swords emerge. We also look at the degree of variability in the deposition of these artefacts and in the composition of the assemblages in question, with considerable repercussions for our understanding of the depositional contexts of metal objects in the Atlantic Bronze Age world in general.
Producción, comunicación, comercio y moneda en la Lusitania romana: el caso de la villa romana de Clavellinas (Torremejía, Badajoz)
2015
Las obras de la A-66 (Autovía de Extremadura) descubrieron un gran número de yacimientos arqueológicos que fueron excavados y documentados en su totalidad. La Villa Romana de Clavellinas es uno de estos ejemplos. Excavada entre junio del 2001 y enero de 2002, aportó gran número de estructuras y de restos materiales, suficientes para considerarla como un centro productivo rural romano. A su vez, también se documentaron un gran número de monedas con una cronología del siglo I d.C. al IV d.C. La catalogación de estas monedas y la valoración conjunta de todos los elementos exhumados nos permiten aproximarnos a la economía rural de la Lusitania Romana. When the A- 66 (Silver highway) was build, …
Towards a poïetic of are or the stakes of a new interpretation of the being : the possibilities and the limits of the renewal of the Metaphysics from…
2012
The “being” remains still and always today an extremely mysterious and polemic object for the philosophers as for the individual who we are. Face to the perpetual reappearance of this object in the form of a fundamental interrogation, the question is to know if we are confronted to an insoluble problem for the reason or if it is a methodological problem which it is advisable to raise. Beyond of a new attempt at destruction of Metaphysics in all its forms and its dimensions by the postmoderns, we must try to reflect today on the true positivity of the questioning of the “being”. From Kant to Bachelard, we are seeing a gradual opening during the history through the way of another practice whi…