Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine.

6533b7d6fe1ef96bd126716f

RESEARCH PRODUCT

Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine.

María Amparo Blázquez Rossana Estellés Maria-jesus Sanz Lara Milian Belén Abarca Rafael Ballesteros

subject

Aporphines Stereochemistry Neutrophils Inflammation complex mixtures chemistry.chemical_compound Ros scavenging Alkaloids Drug Discovery medicine Boldine Humans heterocyclic compounds Aporphine Inhibitory effect chemistry.chemical_classification Reactive oxygen species Oxidase test Dose-Response Relationship Drug Chemistry organic chemicals General Chemistry General Medicine Phenanthrene Phenanthrenes Biochemistry medicine.symptom Reactive Oxygen Species

description

Four phenanthrene and one aporphine alkaloids semi-synthesized from boldine were evaluated for their inhibitory effect on reactive oxygen species (ROS) generation. ROS generation by neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine was inhibited in a concentration dependent manner. Alkaloids exerted similar inhibitory effect in the hypoxanthine-xanthine oxidase system than in stimulated neutrophils, which could be attributed to a direct ROS scavenging activity. None of the alkaloids assayed had any effect on xanthine oxidase activity. Therefore the synthesized alkaloids might constitute an alternative therapy in inflammation disorders in which ROS generation is involved.

year	journal	country	edition	language
2004-06-10	Chemicalpharmaceutical bulletin

10.1248/cpb.52.696 https://pubmed.ncbi.nlm.nih.gov/15187389

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