Search results for "DATES"
showing 10 items of 80 documents
The Roadmap to Finnish Open Science and Research
2015
Finland published its open science roadmap at the end of November 2014. This roadmap is based on the work of the Open Science and Research Initiative (ATT), a cross-administrative initiative established by the Ministry of Education and Culture. The goal of this initiative is to promote open science and availability of information. Exploration of recent developments of open access in the EU shows that Finland is not among the leading countries in the EU. This paper focuses on the practical action plan of this roadmap and describes how the weakest part of Finnish open science, green open access is to be lifted at international top level. peerReviewed
Synthesis, structural and spectroscopic characterization of the α,ω-diammonioalkane hexabromorhodates( III) [H3N(CH2)xNH3]2[H5O2][RhBr6]Br2 (x = 3, 4…
2002
The reaction of rhodium(III) chloride trihydrate with 1,3-diaminopropane and 1,4-diaminobutane in concentrated hydrobromic acid results in the formation of the bis(α,ω-diammonioalkane) diaquahydrogen(1+) hexabromorhodate(III) dibromides [H3N(CH2)xNH3]2[H5O2][RhBr6]Br2 (x = 3, 4). Dark red single crystals were obtained by diffusion-controlled crystallization at room temperature. Both compounds crystallize in space group type P1̄ and their structures are closely related. In view of crystal engineering they are inorganic-organic hybrid materials built up from octahedral [RhBr6]3−, simple Br− and flexible chain-like [H3N(CH2)xNH3]2+ ions with the [H5O2]+ and further Br− ions incorporated and th…
Autorità indipendenti e separazione dei poteri: un'analisi empirica delle nomine e dei mandati
2023
Il presente lavoro intende esaminare i profili di indipendenza «strutturale» che caratterizzano le autorità amministrative indipendenti al fine di stabilire se le modalità di nomina, l’influenzabilità politica e i termini del mandato dei componenti possono condizionare in maniera significativa il concreto esercizio dei compiti affidati. Nel testo si ricostruisce il regime normativo delle procedure e dei requisiti di nomina degli organi di vertice delle autorità. Si esaminano poi i dati relativi ai profili professionali e alla caratterizzazione politica dei componenti, allo scopo di determinare se questi elementi possiedono un’influenza all’interno della procedura di designazione, individuan…
Effects of magnesium chloride on the contractile response of uterus to several agonists in Ca-free solution
1987
Abstract The effects of MgCl2 on the oestrogen-dominated rat uterus have been examined. Tissues were preincubated in a Ca2+- and Mg2+-free medium containing 3 mM EDTA. Most experiments were subsequently performed in a similar medium containing either no EDTA or EDTA (1 mM). When MgCl2 was added cumulatively (1–32 mM) no contractile responses were obtained in Ca,Mg-free medium or in Ca,Mg-free high K+ solution. When 2 mM CaCl2 as added, a sustained contraction was obtained. Subsequent addition of cumulative concentrations of MgCl2 caused concentration-dependent relaxation. Oxytocin, 2 μM, produced a small and sustained contraction in a Ca,Mg-free medium. Addition of MgCl2, 2 mM, increased th…
Privatister – hvem er de, og hva motiverer dem til å lykkes på eksamen? Kartlegging av bakgrunnsvariabler og deres intensjon i lys av en utvidet vers…
2016
Det finnes fa empiriske studier i Norge som kartlegger bakgrunnsvariabler av privatister og undersoker motivasjonsprosesser ved bruk av teoretisk tilnaerming. Hensikten med denne studien er todelt. Det forste malet er a kartlegge ulike sider ved privatistenes bakgrunn, i lys av aldersmessig sammensetting, kjonnsfordeling, antall pameldte eksamener, tidligere erfaring med privatistordningen, grunnene for a ta eksamen, privatistenes tilrettelegging av eksamen pa grunn av saerskilte behov, tidligere kontakt med PPT, og normativ pavirkning. Det andre malet er en teoretisk tilnaerming med fokus pa intensjonelle prosesser i lys av utvidet teori om planlagt atferd (TPB). Resultatene viser at priva…
Comparative study of the rat uterine smooth muscle relaxant activity of three bisbenzyltetrahydroisoquinolines with tetrandrine
1993
Abstract The relaxant activity of three bisbenzyltetrahydroisoquinolines—obaberine, popisonine and lindoldhamine—was examined in rat isolated uterus and their inhibitory potencies were compared with that of tetrandrine. All alkaloids tested relaxed KCl-depolarized rat uterus and totally or partially inhibited oxytocin-induced rhythmic contractions. The degree of methylation of the free phenolic hydroxy groups and the loss of one diarylether bridge influence the potency of relaxant action of these alkaloids. Only alkaloids with absolute configuration 1R,1′S or 1R1′R acted intracellularly, promoting relaxation of contractile responses induced by oxytocin or vanadate in a Ca2+-free medium.
Inhibition of calcium entry induced by cularines and isocrasifoline in uterine smooth muscle.
1991
Abstract The effects of nifedipine, papaverine and four benzylisoquinoline alkaloids (cularine, cularidine, celtisine and isocrasifoline) were studied in isolated rat uterus in order to clarify the mechanism of their relaxant action. All the compounds tested completely relaxed KCl-induced contractions and totally or partially inhibited oxytocin-induced rhythmic contractions. Only papaverine acted intracellularly, promoting relaxation of contractile responses induced by oxytocin or vanadate in a Ca 2+ -free medium. In spite of the structural relationship between papaverine and the other alkaloids, the mechanism of their relaxant action is not the same. The activities of cularine derivatives …
Ethanol inhibits astroglial cell proliferation by disruption of phospholipase D-mediated signaling.
2002
The activation of phospholipase D (PLD) is a common response to mitogenic stimuli in various cell types. As PLD-mediated signaling is known to be disrupted in the presence of ethanol, we tested whether PLD is involved in the ethanol-induced inhibition of cell proliferation in rat cortical primary astrocytes. Readdition of fetal calf serum (FCS) to serum-deprived astroglial cultures caused a rapid, threefold increase of PLD activity and a strong mitogenic response; both effects were dependent on tyrosine kinases but not on protein kinase C. Ethanol (0.1-2%) suppressed the FCS-induced, PLD-mediated formation of phosphatidic acid (PA) as well as astroglial cell proliferation in a concentration…
Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X
2003
Magnesium (Mg) is one of the most abundant ions present in living cells and its plasma concentration is remarkably constant in healthy subjects. Plasma and intracellular Mg concentrations are tightly regulated by several factors. Among them, insulin seems to be one of the most important. In vitro and in vivo studies have demonstrated that insulin may modulate the shift of Mg from extracellular to intracellular space. Intracellular Mg concentration has also been shown to be effective in modulating insulin action (mainly oxidative glucose metabolism), offset calcium-related excitation-contraction coupling, and decrease smooth cell responsiveness to depolarizing stimuli. A poor intracellular M…
Finnish National Guidelines for Open Science
2016
Presentation in Introduction to Open Science seminar, Jyväskylä, 14.11.2016.