Search results for "DC"
showing 10 items of 5463 documents
Adherence to treatment and quality of life of patients with hypertension during the COVID-19 pandemic
2023
Wprowadzenie: Ograniczenie dostępności do rutynowych wizyt kontrolnych w gabinetach lekarskich w czasie pandemii COVID-19, jak również niezgłaszanie się pacjentów z nadciśnieniem tętniczym do placówek ochrony zdrowia w obawie przed zakażeniem mogło zaburzyć współpracę lekarza z pacjentem i pogorszyć przestrzeganie zaleceń terapeutycznych. Cel pracy: Zbadanie jakości życia pacjentów z nadciśnieniem tętniczym oraz ocena przestrzegania przez nich zaleceń terapeutycznych podczas pandemii COVID-19. Materiał i metody: Zbadano 103 pacjentów SPZOZ MSWiA we Wrocławiu. Zastosowano Skróconą wersję ankiety oceniającej jakość życia (WHOQOL-BREF) oraz Skalę adherence w chorobach przewlekłych (ACDS). Wyni…
SAFER : le temps de la rétrocession respectueux de la Constitution
2018
International audience; L’absence de sanction de l’obligation pour la SAFER de rétrocéder un bien préempté dans le délai de 5 ans ne porte pas une atteinte disproportionnée au droit de propriété, à la liberté contractuelle et à la liberté d'entreprendre protégés par les articles 2 et 4 de la Déclaration des droits de l’homme et du citoyen. Cons. Const. DC n° 2018-707, QPC, 25 mai 2018
Ultrafast Interface Charge Separation in Carbon Nanodot-Nanotube Hybrids
2021
Carbon dots are an emerging family of zero-dimensional nanocarbons behaving as tunable light harvesters and photoactivated charge donors. Coupling them to carbon nanotubes, which are well-known electron acceptors with excellent charge transport capabilities, is very promising for several applications. Here, we first devised a route to achieve the stable electrostatic binding of carbon dots to multi- or single-walled carbon nanotubes, as confirmed by several experimental observations. The photoluminescence of carbon dots is strongly quenched when they contact either semiconductive or conductive nanotubes, indicating a strong electronic coupling to both. Theoretical simulations predict a favo…
Like ships passing in the night? Nonstandard work schedules and spousal satisfaction in Finland, the Netherlands and the United Kingdom
2020
This study examined the associations of work schedules and spousal satisfaction among Finnish (n = 347), Dutch (n = 304) and British (n = 337) parents. In addition to comparing parents with nonstandard schedule with parents in regular day work, the study examined separately the roles played in spousal satisfaction of morning, evening, night and weekend work and other working time-related variables (working hours, changes in and influence over one’s work schedules and spouse’s work schedule). The three-country data were analyzed using structural equation modeling with a multigroup procedure in Mplus. Little evidence for negative associations of work schedules and related factors with spousal…
Kolmevuotiaiden päiväkotilasten mitattu fyysinen aktiivisuus
2012
Tämän tutkimuksen tarkoituksena oli selvittää kolmevuotiaiden lasten fyysisen aktiivisuuden määrä ja intensiteetti sekä selvittää täyttyvätkö alle kouluikäisten Varhaiskasvatuksen liikunnan suositukset (2005) kahden tunnin reippaasta päivittäisestä liikunnasta tutkimukseen osallistuvilla lapsilla. Tutkimuksessa vertailtiin myös poikien ja tyttöjen sekä arki- ja viikonlopun päivien välisiä eroja. Aineisto kerättiin 14 vapaaehtoisesta päiväkodista elokuusta lokakuuhun 2010. Lasten fyysinen aktiivisuus mitattiin ActiGraph GT3Xkiihtyvyysmittareilla viiden peräkkäisen päivän ajan. Hyväksyttävä aineisto, vähintään kahdeksan tuntia mittausta kolmena arkipäivänä ja yhtenä viikonlopun päivänä, saati…
The state-of-the-art of collaborative technologies for initial vocational education : a systematic literature review
2018

 
 
 Future workplaces require collaboration skills in which members of different work communities use technologies to solve complex problems. Vocational education and training (VET) programs need to meet the challenge to prepare students to be part of a competent workforce. Particularly initial vocational education is under pressure to develop learners’ collaboration skills and abilities. To date, however, no attempt has been made to perform a comprehensive review of the use of computer-supported collaborative learning (CSCL) technologies across different vocational education settings to account for contextual factors of VET. In this systematic review, 26 published studies …
Wpływ zaangażowania w opiekę nad wnukami na poziom poczucia jakości życia dziadków
2018
Contemporary grandparents are active people, not only in the social but also professional fi eld. Regardless of other duties, one of the socially assigned tasks in the role of grandparent is to take care for grandchildren. As various studies have reported, this task may bring caregivers more losses than benefits (eg Goodman & Silverstein, 2002). In the present study, data from 148 people over 57 years who have looked after grandchildren have been analyzed, to determine whether the amount of time devoted by grandparents to care for grandchildren will affect their sense of quality of life. Grandparents gender, age, and locus of control was controlled. The obtained results confirmed that with …
Activation of NF-kappaB and IL-8 by yersinia enterocolitica invasin protein is conferred by engagement of rac1 and MAP kinase cascades.
2003
International audience; Yersinia enterocolitica triggers activation of the nuclear factor (NF)-kappaB and production of the proinflammatory chemokine interleukin (IL)-8 in intestinal epithelial cells. This activation is due to adhesion of the bacteria via their outer membrane protein invasin to the host cells. Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or Rho, is required for activation of NF-kappaB by invasin. Invasin activated the mitogen activated protein kinases (MAPK) p38 and c-Jun N-terminal protein kinase (JNK) but not extracellular signal regulated …
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
2002
In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours. We show that the level of RhoA, RhoB, Rac1 and Cdc42 protein is largely enhanced in all tumour samples analysed (n=15) as compared to normal tissues originating from the same individual. The same is true for 32P-ADP-ribosylation of Rho proteins which is catalysed by Clostridium botulinum exoenzyme C3. Also the amount of Rho-GDI and ERK2 as well as the level of overall 32P-GTP binding acvitity was tumour-specific elevated, yet to a lower extent than Rho proteins. Although the amount of Rho proteins was enhance…
Molecular Mechanisms of the Blockage of Glioblastoma Motility
2021
Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …