Search results for "DC"
showing 10 items of 5463 documents
Territorial capital and the economic crisis: The role of spatial effects
2013
Activity-geospatial approach forms methodological basis of the concept of geospatial self-organization of a society as new theoretical paradigm of societal geography (SG) with next main principles: a) Self-organization of society and its key subsystems (economical, social, political, spiritual) in specifically localised natural and societal qualities of geospace (Earth's surface space) forms the process of geospatial self-organization of a society and its results - geospatial interests, processes, systems, structures as societal-geospatial phenomena of different scale (global, regional, local, etc.). So societal processes acquire specific geospatial shapes that combine a geospatial (geograp…
Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining
2012
Purpose: The aim of this study was to demonstrate that modern data mining tools can be used as one step in reducing the labor necessary to produce and maintain systematic reviews. Methods: We used four continuously updated, manually curated resources that summarize MEDLINE-indexed articles in entire fields using systematic review methods (PDGene, AlzGene, and SzGene for genetic determinants of Parkinson disease, Alzheimer disease, and schizophrenia, respectively; and the Tufts Cost-Effectiveness Analysis (CEA) Registry for cost-effectiveness analyses). In each data set, we trained a classification model on citations screened up until 2009. We then evaluated the ability of the model to class…
Contraintes et libertés textuelles
2006
The article starts from a conception of language according to which the semiotic units that speakers use do not emanate from individual mental processes but from the socialization of representation instruments which, being individual elements initially, have later been involved in processes of communicative circulation. In the same way that, in each language, verbal uses are limited by a series of restrictions in the constitution of some phonic, lexical or morphosyntactic structures, there are also some other constraints that affect textual genres. This means that these are the product of the history of the uses of language and that they work at a praxeologic level. These ideas apply to the…
MTOR inhibitor-based combination therapies for pancreatic cancer
2018
Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…
Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.
2013
The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…
Progress in HAXPES performance combining full-field k-imaging with time-of-flight recording
2019
Journal of synchrotron radiation 26(6), 1996-2012 (2019). doi:10.1107/S1600577519012773
Skeleton-Based Multiview Reconstruction
2016
International audience; The advantage of skeleton-based 3D reconstruction is to completely generate a single 3D object from well chosen views. Having numerous views is necessary for a reliable reconstruction but projections of skeletons lead to different topologies. We reconstruct 3D objects with curved medial axis (whose topology is a tree) from the perspective skeletons on an arbitrary number of calibrated acquisitions. The main contribution is to estimate the 3D skeleton, from multiple images: its topology is chosen as the closest to those of the perspective skeletons on the set of images, which means that the number of topology changes to map the 3D skeleton topology to topologies on im…
UNA diversidad otra: mirada trans-formadora desde el trabajo social feminista. Tres historias de vidas transexuales
2014
La transfobia como problema social, requiere con urgencia ser examinada, investigada, cuestionada y confrontada, desde el campo de las ciencias sociales, y particularmente desde la disciplina del trabajo social feminista, debido a la poca producción científica realizada en este campo de conocimiento. La alianza de los sectores trans más críticos, junto a la praxis del trabajo social feminista, supone un desafío revolucionador y transgresor como forma de empoderamiento sociopolítico, sexual, e identitario —por el cuestionamiento que ambos realizan acerca del statu quo, y del sistema sexo-género—. Debemos perseguir la quimera de la flexibilización de las categorías de género existentes, apost…
Indeks organów istniejących w kościołach i kaplicach diecezji gliwickiej
2022
The article is a presentation of organ instruments found in Catholic churches and chapels in the Diocese of Gliwice. The first part of the article is a short description of the history of the diocese. The main part of the article is a list of organs in alphabetical order by place names and church names including 134 instruments. The last part of the article is a summary prepared based on a few criteria: the number of organs built in chronological order, the builders of the instruments and the technical and construction solutions used.
The Effects of Transcutaneous Spinal Direct Current Stimulation on Neuropathic Pain in Multiple Sclerosis: Clinical and Neurophysiological Assessment
2019
Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality of life. Spinal mechanisms may contribute to the pathogenesis of neuropathic pain in MS. Converging evidence from animal models and neurophysiological and clinical studies in humans suggests a potential effect of transcranial direct current stimulation (tc-DCS) on neuropathic pain. Spinal application of DCS, i.e., transcutaneous spinal DCS (ts-DCS), may modulate nociception through inhibition of spinal reflexes. Therefore, ts-DCS could represents an effective, safe and well-tolerated treatment for neuropathic pain in MS, a largely unexplored topic. This…