Search results for "DDR"
showing 10 items of 108 documents
The formation of structurally relevant units in artificial grammar learning
2002
A total of 78 adult participants were asked to read a sample of strings generated by a finite state grammar and, immediately after reading each string, to mark the natural segmentation positions with a slash bar. They repeated the same task after a phase of familiarization with the material, which consisted, depending on the group involved, of learning items by rote, performing a short term matching task, or searching for the rules of the grammar. Participants formed the same number of cognitive units before and after the training phase, thus indicating that they did not tend to form increasingly large units. However, the number of different units reliably decreased, whatever the task that…
Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients w…
2015
Background The aim of the study was to better characterise the immunological origin and the behaviour of interleukin (IL)-23-responsive innate lymphoid cells (ILCs) in the gut, synovial fluid (SF) and bone marrow (BM) of patients with ankylosing spondylitis (AS).Methods ILC1, ILC2 and ILC3 cells were determined and characterised by confocal microscopy and flow cytometry in ileal and BM biopsies, in peripheral blood (PB) and SF mononuclear cells obtained from patients with AS and controls. Mucosal vascular addressin cell adhesion molecule 1 (MADCAM-1), IL-7, IL-15 and aggregates of lymphoid tissue inducer cells (LTi) were evaluated by immunohistochemistry. The in vitro ability of epithelial …
Expression of Peripheral Node Addressins by Plasmacytic Plaque of Children, APACHE, TRAPP, and Primary Cutaneous Angioplasmacellular Hyperplasia.
2018
High-endothelial venules are a common feature of 3 types of cutaneous pseudolymphomas: pretibial lymphoplasmacytic plaque (PLP) of children, acral pseudolymphomatous angiokeratoma of children (APACHE), and T-cell rich angiomatoid polypoid pseudolymphoma (TRAPP). In addition, primary cutaneous angioplasmacellular hyperplasia (PCAH) overlaps with these other 3 conditions. We intend to study the expression of peripheral node addressins in PLP, APACHE, TRAPP, and PCAH. We studied 1 case of PLP, 2 cases of APACHE, 2 cases of TRAPP, and 2 cases of PCAH. Immunostainings for MECA-79 and WT-1 were obtained in all cases. All cases showed a dense lymphohistiocytic dermal inflammatory infiltrate with a…
Accumulated safety data of micafungin in therapy and prophylaxis in fungal diseases
2011
To define better the safety profile of micafungin, an analysis of micafungin clinical trial safety data was undertaken.Adverse event data were pooled worldwide from 17 clinical efficacy and safety studies. Adverse events were coded using the Medical Dictionary for Regulatory Activities version 5.0.In the pooled clinical trial data set, 3028 patients received at least one dose of micafungin. The mean age of patients was 41.4 years; with 296 (9.8%) children (16 years) and 387 (12.8%) elderly patients (≥ 65 years). Common underlying conditions were hematopoietic stem cell and other transplantations (26.1%), malignancies (20.8%) and HIV (32.9%). Mean exposure was 18 days for adults and 29 days …
Discoidin domain receptor 1 gene variants are associated with decreased white matter fractional anisotropy and decreased processing speed in schizoph…
2019
Abstract DDR1 has been linked to schizophrenia (SZ) and myelination. Here, we tested whether DDR1 variants in people at risk for SZ influence white matter (WM) structural variations and cognitive processing speed (PS). First, following a case-control design (Study 1), SZ patients (N = 1193) and controls (N = 1839) were genotyped for rs1264323 and rs2267641 at DDR1, and the frequencies were compared. We replicated the association between DDR1 and SZ (rs1264323, adjusted P = 0.015). Carriers of the rs1264323AA combined with the rs2267641AC or CC genotype are at risk to develop SZ compared to the other genotype combinations. Second, SZ patients (Study 2, N = 194) underwent an evaluation of PS …
Mitigating DDoS using weight‐based geographical clustering
2020
Distributed denial of service (DDoS) attacks have for the last two decades been among the greatest threats facing the internet infrastructure. Mitigating DDoS attacks is a particularly challenging task as an attacker tries to conceal a huge amount of traffic inside a legitimate traffic flow. This article proposes to use data mining approaches to find unique hidden data structures which are able to characterize the normal traffic flow. This will serve as a mean for filtering illegitimate traffic under DDoS attacks. In this endeavor, we devise three algorithms built on previously uncharted areas within mitigation techniques where clustering techniques are used to create geographical clusters …
Pheromone-induced olfactory memory in newborn rabbits: Involvement of consolidation and reconsolidation processes.
2009
Mammary pheromone (MP)-induced odor memory is a new model of appetitive memory functioning early in a mammal, the newborn rabbit. Some properties of this associative memory are analyzed by the use of anisomycin as an amnesic agent. Long-term memory (LTM) was impaired by anisomycin delivered immediately, but not 4 h after either acquisition or reactivation. Thus, the results suggest that this form of neonatal memory requires both consolidation and reconsolidation. By extending these notions to appetitive memory, the results reveal that consolidation and reconsolidation processes are characteristics of associative memories of positive events not only in the adult, but also in the newborn.
Comparison of implementations of the lattice-Boltzmann method
2008
AbstractSimplicity of coding is usually an appealing feature of the lattice-Boltzmann method (LBM). Conventional implementations of LBM are often based on the two-lattice or the two-step algorithm, which however suffer from high memory consumption and poor computational performance, respectively. The aim of this work was to identify implementations of LBM that would achieve high computational performance with low memory consumption. Effects of memory addressing schemes were investigated in particular. Data layouts for velocity distribution values were also considered, and they were found to be related to computational performance. A novel bundle data layout was therefore introduced. Address…
An efficient distributed algorithm for generating and updating multicast trees
2006
As group applications are becoming widespread, efficient network utilization becomes a growing concern. Multicast transmission represents a necessary lower network service for the wide diffusion of new multimedia network applications. Multicast transmission may use network resources more efficiently than multiple point-to-point messages; however, creating optimal multicast trees (Steiner Tree Problem in networks) is prohibitively expensive. This paper proposes a distributed algorithm for the heuristic solution of the Steiner Tree Problem, allowing the construction of effective distribution trees using a coordination protocol among the network nodes. Furthermore, we propose a novel distribut…
A new Media Access Control layer Quality of Service multicast scheme for IEEE 802.11s based wireless mesh networks
2014
Inderscience Publishers; International audience; We propose a new Media Access Control (MAC) layer enabling Quality of Service (QoS) multicast scheme for IEEE 802.11s networks, where a unicast routing protocol called HWMP (Hybrid Wireless Mesh Protocol) is defined. The HWMP protocol is more adapted for best effort traffic, that's why its usage is not suitable for real time multimedia applications. The goal of our proposed mechanism is to take into account multicast communication under QoS constraints for the IEEE 802.11s mesh networks where no QoS multicasting has been defined. Our multicasting scheme handles QoS guarantee for real time applications. Indeed, our scheme is based on finding t…