Search results for "DELE"
showing 10 items of 631 documents
Identification of the mstE Gene Encoding a Glucose-inducible, Low Affinity Glucose Transporter in Aspergillus nidulans
2006
The mstE gene encoding a low affinity glucose transporter active during the germination of Aspergillus nidulans conidia on glucose medium has been identified. mstE expression also occurs in hyphae, is induced in the presence of other repressing carbon sources besides glucose, and is dependent on the function of the transcriptional repressor CreA. The expression of MstE and its subcellular distribution have been studied using a MstE-sGFP fusion protein. Concordant with data on mstE expression, MstE-sGFP is synthesized in the presence of repressing carbon sources, and fluorescence at the periphery of conidia and hyphae is consistent with MstE location in the plasma membrane. Deletion of mstE …
Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression al…
2002
AbstractGenomic aberrations in a series of paired biopsy samples from patients who presented initially with follicle center lymphoma (FCL) and subsequently transformed to diffuse large B-cell lymphoma (DLBCL) were measured by array comparative genomic hybridization (CGH). The consequences of these aberrations on gene expression were determined by comparison with expression analysis on these specimens using cDNA microarrays. A heterogeneous pattern of acquired genomic abnormalities was observed upon transformation, some of which were recurrent in small subsets of patients. Some of the genomic aberration acquired upon transformation, such as gain/amplification of 1q21-q24, 2p16 (REL/BCL11A ge…
Analysis of expression of an alternative La (SS-B) cDNA and localization of the encoded N- and C-terminal peptides
1997
AbstractA deletion of an (A)-residue was detected in a cDNA encoding for the nuclear autoantigen La/SS-B. The cDNA was recently isolated from a cDNA library made from peripheral blood lymphocytes of a patient with primary Sjögren's Syndrome. The region, where the deletion occurred, represents a hot spot region in the La gene(s). It leads to a frame shift mutation and a premature stop codon eleven amino acids downstream of the deletion site within one of the protease sensitive regions of the La protein. In spite of the frame shift mutation expression of full length La protein occurred efficiently in E. coli. Full length La protein was also made in SF9 cells infected with recombinant baculovi…
The Rate and Molecular Spectrum of Spontaneous Mutations in Arabidopsis thaliana
2010
Evolution in Action Rates of evolution in gene and genome sequences have been estimated, but these estimates are subject to error because many of the steps of evolution over the ages are not directly measurable or are hidden under subsequent changes. Ossowski et al. (p. 92 ) now provide a more accurate measurement of how often spontaneous mutations arise in a nuclear genome. Mutations arising over 30 generations were compared by sequencing DNA from individual Arabidopsis thaliana plants. UV- and deamination-induced mutagenesis appeared to bias the type of mutations found.
Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms.
2019
Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restriction endonuclease (mtEcoBI) results in unexpected metabolic reprogramming in adult flies, distinct from effects on OXPHOS. Carbohydrate utilization was repressed, with catabolism shifted towards lipid oxidation, accompanied by elevated serine synthesis. Cleavage and translocation, the two modes of mtEcoBI action, repressed carbohydrate rmetabolism via two different mechanisms. DNA cleavage activ…
Brevi considerazioni sulle c.d. deliberazioni implicite: superamento della categoria?
2010
Il tema dell’ammissibilità, nel diritto societario italiano, della categoria delle c.d. deliberazioni assembleari implicite è stato autorevolmente studiato in epoca ormai non più recente. Scopo del presente articolo è quello di svolgere alcune, brevi riflessioni sulla problematica in esame, avendo particolare riguardo al modello della Società per azioni. Le considerazioni in oggetto si sviluppano da una sentenza resa dalla Corte di Cassazione, a Sezioni unite, nell’agosto 2008 (Cass. s. u. 29- 08- 2008, n. 21933). Con questa decisione si è stabilito che l’approvazione da parte dell’assemblea del bilancio d’esercizio di una società di capitali contenente una posta relativa al compenso percep…
Deleghe di poteri e responsabilità
2015
Le concrete esigenze imprenditoriali consistenti nel bisogno di strutturare le società in centri decisionali che siano in grado di compiere scelte operative tempestive e dimostrare, all’occorrenza, specializzazione nell’esercizio di funzioni strategiche, nonché le relative attenzioni ad esse recentemente dedicate da parte del legislatore, ma anche di Autori e giurisprudenza, si pongono a fondamento della scelta di trattare della delega di poteri, quale tipica modalità di organizzazione della gestione pluripersonale delle società in epoca odierna, e delle responsabilità derivanti dal suo esercizio. Si da atto dell’incisività del contributo apportato dalla riforma organica delle società di ca…
Trust-aware RBAC
2012
Published version of a chapter in the book: Computer Network Security. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-33704-8_9 In this paper we propose a trust-aware enhancement of RBAC (TA-RBAC) that takes trustworthiness of users into consideration explicitly before granting access. We assume that each role in the framework is associated with an expression that describe trustworthiness of subjects required to be able to activate the role, and each subject (user) has assigned trustworthiness level in the system. By adding trustworthiness constraints to roles we enhance system, for example, with more flexible ability to delegate roles, to control reading/updating…
Party Leadership Selection in Latvia: Divergent Practices of Precursory Delegation
2020
The pattern of political competition in Latvia has been notably stable. A majority of right-of-centre parties represent the interests of ethnic Latvians and faces a minority of left-of-centre parties claiming to advocate the interests of East Slavic minorities. However, actors in this pattern have changed notably. Every parliamentary election since the restoration of independence has generated at least one new party represented in the Latvian parliament, with the turnover of members of parliament oscillating between 25 per cent and 60 per cent.