Search results for "DELE"

A Rare Case of Deletion in 2q24.1: Clinical Features and Response to Gh Hormone Treatment

2016

Background: Chromosomal imbalances are often due to sub microscopic deletions or duplications not evidenced by conventional cytogenetic methods. Objective and hypotheses: CGH array can help in the diagnosis of severe short stature, associated with mental retardation and dysmorphisms. Method: We describe the clinical case of a 13.1-year-old girl, born at 35 weeks, from a triplets pregnancy. She was 127.5 cm (!K5 SDS), 33 kg (! K3 SDS); SPAN: 122 cm; PH2B2, bone age: 11 years; mild psychomotor delay, facial dysmorphism (malformed years with a low-set, microcephaly) and feet malformations (flexion deformities, broad halluces). Born SGA, with a growth velocity ! K3 SDS, a severe short stature s…

Suppression of humoral immune response against herpes simplex virus induced by defective strains, ts- and TK- mutants.

1988

Suppression of humoral antibody formation against HSV is not only induced by replicating Herpes simplex virus type 2 (HSV-2) but also by the defective strain ANG and the deletion mutant 1301 of Herpes simplex virus type 1 (HSV-1). Moreover, ts-mutants A, H, K, S, 1201 and 1208 of HSV-1 as well as some ts-mutants of HSV-2 and “defective-interfering” particles of HSV-1 after high multiplicity of infection-passages induced suppression. Treatment of infected mice with ACG reduced antibody-formation but did not result in suppression. UV-irradiation of the antibody producing strain Len of HSV-1 strongly reduces antibody formation and induces suppression. Experiments using a series of intertypic r…

Impact of a Three Amino Acid Deletion in the CH2 Domain of Murine IgG1 on Fc-Associated Effector Functions

2008

Abstract Four murine IgG subclasses display markedly different Fc-associated effector functions because of their differential binding to three activating IgG Fc receptors (FcγRI, FcγRIII, and FcγRIV) and C1q. Previous analysis of IgG subclass switch variants of 34-3C anti-RBC monoclonal autoantibodies revealed that the IgG1 subclass, which binds only to FcγRIII and fails to activate complement, displayed the poorest pathogenic potential. This could be related to the presence of a three amino acid deletion at positions 233–235 in the CH2 domain uniquely found in this subclass. To address this question, IgG1 insertion and IgG2b deletion mutants at positions 233–235 of 34-3C anti-RBC Abs were …

Global capitalism guided by desire- Solvang, CA, as a “real” place

2021

Abstract How to deal with the transformation of place in the face of global capitalism is marked by many active debates. This paper dives into the transformation of the city of Solvang in California, from an agricultural village to a tourist destination. One way to analyse the process is to treat it as commodification, where values produced in places are being turned into exchangeable commodities. What results from such critical studies of capitalism too often result in apathy rather than positive action, it tends to deal less with ‘the real world’ than thought experiments about possible worlds. Another approach connects to the relational turn and the application of assemblage theory in stu…

Optimal extension of multispectral image demosaicking algorithms for setting up a one-shot camera video acquisition system

2022

Multispectral images are acquired using multispectral cameras equipped with CCD or CMOS sensors which sample the visible or near infrared spectrum according to specific spectral bands. A mosaic of multispectral MSFA filters is superimposed on the surface of the sensors to acquire a raw image called an MSFA image. In the MSFA image, only one spectral band is available per pixel, the demosaicking process is necessary to estimate the multispectral image at full spatio-spectral resolution. Motivated by the success of single-sensor cameras capturing the image in a single exposure that use CFA filters, we performed a comparative study of a few recent color image demosaicking algorithms and experi…

Image and Copy in Contemporary Deconstruction of Platonism

2017

This paper aims at investigating the relationship between some contemporary Interpretations of Plato's Ontology and the Theory of Image-Copy connection developed in many Dialogues such as Sophist, Philebus, Timaeus and Republic. By examinating some of the most relevant criticisms to this Theory cast by french Philosophers such as Deleuze and Derrida and by retracing the roots of these criticisms to the common source of Nietzsche's and Heidegger's Thought, the paper argues a way to overcome the stiff opposition which is commonly held between these two fronts, thus trying to refine the hermeneutical approach to Plato which almost dominated the XX century.

Conceptual design of the TRACE detector readout using a compact, dead time-less analog memory ASIC

2015

[EN] The new TRacking Array for light Charged particle Ejectiles (TRACE) detector system requires monitorization and sampling of all pulses in a large number of channels with very strict space and power consumption restrictions for the front-end electronics and cabling. Its readout system is to be based on analog memory ASICs with 64 channels each that sample a View the MathML source window of the waveform of any valid pulses at 200 MHz while discarding any other signals and are read out at 50 MHz with external ADC digitization. For this purpose, a new, compact analog memory architecture is described that allows pulse capture with zero dead time in any channel while vastly reducing the tota…

2014

Is there a general theorem that tells us when we can hope for exponential speedups from quantum algorithms, and when we cannot? In this paper, we make two advances toward such a theorem, in the black-box model where most quantum algorithms operate. First, we show that for any problem that is invariant under permuting inputs and outputs (like the collision or the element distinctness problems), the quantum query complexity is at least the 9 th root of the classical randomized query complexity. This resolves a conjecture of Watrous from 2002. Second, inspired by recent work of O’Donnell et al. and Dinur et al., we conjecture that every bounded low-degree polynomial has a “highly influential” …

Anomalies in Sepiolinae hectocotylization

1997

Four cases of anomalies of the copulatory arm in Sepiolinae (Cephalopoda: Sepiolidae) are reported. In one case (Sepietta oweniana), both dorsal arms were modified resulting in double hecocotylization. In another specimen probably of the same species the copula-tory apparatus was formed by two fleshy multilobed formations situated on the dorsal and ventral side of the arm base. In one specimen of Rondeletiola minor the copulatory apparatus was inversely positioned on the arm base, and in one Sepioh intermedia specimen the inner free portion of the wrinkled tubercle was markedly enlarged.

Neuronal precursor-specific activity of a human doublecortin regulatory sequence.

2005

The doublecortin (DCX) gene encodes a 40-kDa microtubule-associated protein specifically expressed in neuronal precursors of the developing and adult CNS. Due to its specific expression pattern, attention was drawn to DCX as a marker for neuronal precursors and neurogenesis, thereby underscoring the importance of its promoter identification and promoter analysis. Here, we analysed the human DCX regulatory sequence and confined it to a 3.5-kb fragment upstream of the ATG start codon. We demonstrate by transient transfection experiments that this fragment is sufficient and specific to drive expression of reporter genes in embryonic and adult neuronal precursors. The activity of this regulator…