Search results for "DELE"
showing 10 items of 631 documents
Transparency of peer review: a semi-structured interview study with chief editors from social sciences and humanities
2021
Background Open peer review practices are increasing in medicine and life sciences, but in social sciences and humanities (SSH) they are still rare. We aimed to map out how editors of respected SSH journals perceive open peer review, how they balance policy, ethics, and pragmatism in the review processes they oversee, and how they view their own power in the process. Methods We conducted 12 pre-registered semi-structured interviews with editors of respected SSH journals. Interviews consisted of 21 questions and lasted an average of 67 min. Interviews were transcribed, descriptively coded, and organized into code families. Results SSH editors saw anonymized peer review benefits to outweigh t…
Spain: Conviviality, Social Relationships and Democracy at the Basis of Spanish Sports Clubs’ Culture
2020
This chapter provides an overview of the main functions of sports clubs in Spanish society with regard to social integration, democratic involvement and voluntary work. At the European level, Spanish sports clubs are among the front-runners in terms of presence of people with disabilities, at the average when it comes to people with migrant background and far below the average concerning people over 65 years old and women. Talking about democratic involvement and engagement for the community, most of the clubs try to involve members when making important decisions and delegate decision-making from the board to their committees. On the other hand, their members report the democratic culture …
Why are viral genomes so fragile? The bottleneck hypothesis
2021
If they undergo new mutations at each replication cycle, why are RNA viral genomes so fragile, with most mutations being either strongly deleterious or lethal? Here we provide theoretical and numerical evidence for the hypothesis that genetic fragility is partly an evolutionary response to the multiple population bottlenecks experienced by viral populations at various stages of their life cycles. Modelling within-host viral populations as multi-type branching processes, we show that mutational fragility lowers the rate at which Muller’s ratchet clicks and increases the survival probability through multiple bottlenecks. In the context of a susceptible-exposed-infectious-recovered epidemiolog…
Molecular and patho-physiological basis of syndromes with developmental anomalies and intellectual disability
2013
Intellectual disability (ID) corresponds to abnormal intellectual performances and adaptive functions, beginning in childhood. It is estimated that 2-3% of individuals develop a ID, which represents a significant medical challenge since people with ID are frequently in situations of social dependence. Overall, a critical involvement of genetic factors in this disease is suspected. To date, several hundreds of genes are known to be responsible for ID. The ID is particularly characterized by extreme clinical and genetic heterogeneity, that made it resistant to conventional genetic studies. However, it is classicaly separated between syndromic ID, which may be clinically recognizable due to as…
Almost disjoint spanning trees: relaxing the conditions for completely independent spanning trees
2017
International audience; The search of spanning trees with interesting disjunction properties has led to the introduction of edge-disjoint spanning trees, independent spanning trees and more recently completely independent spanning trees. We group together these notions by dening (i, j)-disjoint spanning trees, where i (j, respectively) is the number of vertices (edges, respectively) that are shared by more than one tree. We illustrate how (i, j)-disjoint spanning trees provide some nuances between the existence of disjoint connected dominating sets and completely independent spanning trees. We prove that determining if there exist two (i, j)-disjoint spanning trees in a graph G is NP-comple…
Bankas "Citadele" sociālo tīklu Facebook, Twitter un Instagram komunikācijas analīze (2018 - 2019)
2020
Bakalaura darba Bankas “Citadele” sociālo tīklu Facebook, Twitter un Instagram komunikācijas analīze (2018 – 2019) mērķis - izpētīt bankas “Citadele” mārketinga komunikāciju sociālajos tīklos, uzmanību vēršot saturam par digitālajām inovācijām un to, kā šis saturs ir veicinājis auditorijas izpratni par digitālajām inovācijām un iedrošinājis tās lietot. Pētījuma pirmo daļu veido teorētiskās atziņas par mārketinga komunikāciju, pārdošanu digitālajā laikmetā, sociālo mediju un sociālo tīklu pielietojumu mārketinga komunikācijā. Pētījuma empīrisko datu iegūšanai izmantota kontentanalīze, daļēji strukturētā intervija un aptauja. Pētīts bankas “Citadele” sociālo tīklu Facebook, Twitter un Instagr…
Expression of the Anti-amyloidogenic Secretase ADAM10 Is Suppressed by Its 5′-Untranslated Region*
2010
Proteolytic processing of the amyloid precursor protein by alpha-secretase prevents formation of the amyloid beta-peptide (Abeta), which is the main constituent of amyloid plaques in brains of Alzheimer disease (AD) patients. alpha-Secretase activity is decreased in AD, and overexpression of the alpha-secretase ADAM10 (a disintegrin and metalloprotease 10) in an AD animal model prevents amyloid pathology. ADAM10 has a 444-nucleotide-long, very GC-rich 5'-untranslated region (5'-UTR) with two upstream open reading frames. Because similar properties of 5'-UTRs are found in transcripts of many genes, which are regulated by translational control mechanisms, we asked whether ADAM10 expression is…
Homozygous deletion of ATC1 and NTC1 genes in Candida parapsilosis abolishes trehalase activity and affects cell growth, sugar metabolism, stress res…
2015
A double homozygous atc1Δ/atc1Δ/ntc1Δ/ntc1Δ mutant (atc1Δ/ntc1Δ KO) was constructed in the pathogen opportunistic yeast Candida parapsilosis by disruption of the two chromosomal alleles coding for NTC1 gene (encoding a neutral trehalase) in a Cpatc1Δ/atc1Δ background (atc1Δ KO strain, deficient in acid trehalase). The Cpatc1Δ/ntc1Δ KO mutant failed to counteract the inability of Cpatc1Δ cells to metabolize exogenous trehalose and showed a similar growth pattern on several monosaccharides and disaccharides. However, upon prolonged incubation in either rich medium (YPD) or nutrient-starved medium the viability of Cpatc1Δ cells exhibited a sensitive phenotype, which was augmented by further Cp…
Ras-pathway has a dual role in yeast galactose metabolism
2007
AbstractIn the yeast Saccharomyces cerevisiae the genes involved in galactose metabolism (GAL1,7,10) are transcriptionally activated more than a 1000-fold in the presence of galactose as the sole carbon source in the culture media. In the present work, we monitored the activity of the GAL10 gene promoter in different Ras-cAMP genetic backgrounds. We demonstrate that overexpression of C-terminus of the nucleotide exchange factor Cdc25p stimulates GAL10 transcription in yeast strains carrying the contemporary deletion of both RAS genes. Moreover, the deletion of the chromosomal CDC25 gene provokes impaired growth on galactose based media in yeast strain lacking both RAS genes and adenylate cy…
Sch 9p kinase and the Gcn4p transcription factor regulate glycerol production during winemaking
2017
Grape juice fermentation is a harsh environment with many stressful conditions, and Saccharomyces cerevisiae adapts its metabolism in response to those environmental challenges. Many nutrient-sensing pathways control this feature. The Tor/Sch9p pathway promotes growth and protein synthesis when nutrients are plenty, while the transcription factor Gcn4p is required for the activation of amino acid biosynthetic pathways. We previously showed that Sch9p impact on longevity depends on the nitrogen/carbon ratio. When nitrogen is limiting, SCH9 deletion shortens chronological life span, which is the case under winemaking conditions. Its deletion also increases glycerol during fermentation, so the…