Search results for "DEMAND"

Evaluation of an alternative dosing regimenwith tadalafil, three times per week, for men with erectile dysfunction: SURE study in Italy.

2007

AIM: To examine the preference for two dosing regimens of 20 mg of tadalafil, on demand or three times per week, in men affected with erectile dysfunction (ED) in Italy. METHODS: Scheduled Use versus on demand Regimen Evaluation (SURE) is a multicenter, crossover and open-label study, involving 94 urology centers in Italy. Patients aged 18 years or older affected with ED for at least 3 months were enrolled and randomized to 20 mg of tadalafil treatment on demand or three times per week for 5-6 weeks. After a 1-week washout, patients were crossed over to the alternate regimen for 5-6 weeks. A treatment preference question was used to determine the preferred treatment regimen. International I…

Need for global action for cancer control.

2008

Result and cost of hepatic chemoembolisation with drug eluting beads in 21 patients.

2012

Abstract Purpose The aim of our study was to assess the results and cost of a treatment strategy involving transarterial chemoembolisation with drug eluting beads (DEB-TACE) in patients with unresectable non-metastatic hepatocellular carcinoma (HCC). Patients and methods This study included all patients treated with DEB-TACE in our hospital between January 2009 and December 2010. All patients received DEB-TACE on demand and were evaluated after each session. Results Twenty-one patients received an average of 1.3 sessions. The median time to treatment discontinuation and median progression-free survival was 181 days and 295 days, respectively. Toxicity caused treatment discontinuation in thr…

A Production Scenarios Generation Tool for Manufacturing Strategy Characterization

2008

Impact of Business Strategy on Production Problem Dynamics

2008

Les followers ont-ils vraiment de l'importance dans le modèle de Stackelberg?

2011

In this paper, we consider a T-stage linear model of Stackelberg oligopoly. First, we show geometrically and analytically that under the two conditions of linear market demand and identical constant marginal costs, the T-stage Stackelberg model reduces to a model where T oligopolies exploit residual demand sequentially. At any stage, leaders behave as if followers did not matter. Second, we study social welfare and convergence toward competitive equilibrium. Especially, we consider the velocity of convergence as the number of firms increases. The convergence is faster when reallocating firms from the most to the less populated cohort until equalizing the size of all cohorts.

Spatial mapping of price competition using logit-type market share models and store-level scanner-data

2009

This paper proposes a methodology to obtain reliable spatial maps of price competition using store-level scanner data. Specifically, a procedure to obtain a symmetric matrix of similarities between brands considering their substitutability depending on price variations is proposed. The matrix is derived from a market response model where price cross-effects are split into two components. The first component accounts for the fact that price variation in one brand can have different effects to price variation in other brands (ie j → j′≠j′ → j). The second component accounts for the fact that the price of each brand can have different effects across competing brands (ie j → j′≠j → j ″). The ma…

Improving demand forecasting accuracy using nonlinear programming software

2006

We address the problem of forecasting real time series with a proportion of zero values and a great variability among the nonzero values. In order to calculate forecasts for a time series, the model coefficients must be estimated. The appropriate choice of values for the smoothing parameters in exponential smoothing methods relies on the minimization of the fitting errors of historical data. We adapt the generalized Holt–Winters formulation so that it can consider the starting values of the local components of level, trend and seasonality as decision variables of the nonlinear programming problem associated with this forecasting procedure. A spreadsheet model is used to solve the problems o…

Generic Advertising, Brand Advertising and Price Competition: An Analysis of Free-Riding Effects and Coordination Mechanisms

2010

The main purpose of generic advertising is to enlarge the total market demand rather than capturing further slices from competitors. Several studies point out emergence of free-riding behavior under independent contribution and suggest use of coordination mechanism. However, existing literature does not shed light on the conditions under which generic advertising can be detrimental (beneficial) to stronger firms weakening (strengthening) their competitive advantage. Also, under a setting including both price and brand advertising competition, coordination in generic advertising has not been unraveled. In order to deal with such issues, we consider a one-stage duopoly game in which two firms…

Predictors of tourist engagement: Travel motives and tourism destination profiles

2020

Abstract The aim of this study is to investigate the influence of travel motives and regional tourism destinations on positive/negative engagement with a destination management organisation (DMO). According to previous literature, travel motives were classified as push and pull motives, and regional tourism destinations were classified by tourist demand behaviour. To achieve the objective, the totality of posts about regional tourism destinations published on the Brand Spain's Official Facebook Fanpage during a year were analysed (418), along with audience reactions (127,750), comments (3219) and shares to such posts. A content analysis was performed, with a regression analysis (optimal sca…