Search results for "DETA"

Application of thermodynamics to driven systems

2007

Application of thermodynamics to driven systems is discussed. As particular examples, simple traffic flow models are considered. On a microscopic level, traffic flow is described by Bando's optimal velocity model in terms of accelerating and decelerating forces. It allows to introduce kinetic, potential, as well as total energy, which is the internal energy of the car system in view of thermodynamics. The latter is not conserved, although it has certain value in any of two possible stationary states corresponding either to fixed point or to limit cycle in the space of headways and velocities. On a mesoscopic level of description, the size n of car cluster is considered as a stochastic varia…

High-overtone bulk acoustic resonator as passive ground penetrating RADAR cooperative targets

2013

International audience; RAdio-frequency Detection And Ranging instruments—RADARs—are widely used for applications aimed at measuring passive target velocity or ranging for various metrology applications such as ground position and localization. Within the context of using piezoelectric acoustic passive sensors as cooperative targets to RADARs probed through a radiofrequency link, this paper reports on investigating the compatibility of narrowband resonator architectures with the classical operation mode of wideband RADAR instruments. Since single mode resonators are hardly compatible due to the limited bandwidth of their spectrum, the investigation has been extended to High-overtone Bulk Ac…

Transport coefficients of self-propelled particles: Reverse perturbations and transverse current correlations

2019

The reverse perturbation method [Phys. Rev. E 59, 4894 (1999)] for shearing simple liquids and measuring their viscosity is extended to the Vicsek model (VM) of active particles [Phys. Rev. Lett. 75, 1226 (1995)] and its metric-free version. The sheared systems exhibit a phenomenon that is similar to the skin effect of an alternating electric current: Momentum that is fed into the boundaries of a layer decays mostly exponentially toward the center of the layer. It is shown how two transport coefficients, i.e., the shear viscosity $\ensuremath{\nu}$ and the momentum amplification coefficient $\ensuremath{\lambda}$, can be obtained by fitting this decay with an analytical solution of the hydr…

Combining inulin multifunctional polycation and magnetic nanoparticles: Redox-responsive siRNA-loaded systems for magnetofection

2019

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are recognized as one of the most promising agents for theranostic applications. Among methods designed for siRNA delivery, magnetofection, that is, nucleic acid cell uptake under the influence of a magnetic field acting on magnetic nucleic acid vectors, is emerging as a unique approach to combining advantages such as strong improvement of the kinetics of the delivery process and the possibility of localizing nucleic acid delivery to an area where the magnetic field is applied. This paper reports on the preparation of siRNA loaded magnetoplexes&mdash

Galactosylated polyaspartamide copolymers for siRNA targeted delivery to hepatocellular carcinoma cells

2017

The limited efficacy of available treatments for hepatocellular carcinoma (HCC) requires the development of novel therapeutic approaches. We synthesized a novel cationic polymer based on α,β-poly-(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) for drug delivery to HCC cells. The copolymer was synthesized by subsequent derivatization of PHEA with diethylene triamine (DETA) and with a polyethylene glycol (PEG) derivative bearing galactose (GAL) molecules, obtaining the cationic derivative PHEA-DETA-PEG-GAL. PHEA-DETA-PEG-GAL has suitable chemical-physical characteristics for a potential systemic use and can effectively deliver a siRNA (siE2F1) targeted against the transcription factor E2F1, a gen…

Long-term patterns of effort-reward imbalance and over-commitment: Investigating occupational well-being and recovery experiences as outcomes

2013

The aim of this study was, first, to identify long-term patterns of effort-reward imbalance (ERI) and over-commitment (OVC), and, second, to examine how occupational well-being (burnout, work engagement) and recovery experiences (psychological detachment, relaxation, mastery and control) differ in these patterns. The study was based on follow-up data with three measurement points (2006, 2008, 2010) collected from Finnish managers (N=298). Latent Profile Analysis resulted in five long-term ERI-OVC patterns: a high-risk pattern (high ERI, high OVC), found in 20% of the participants; a low-risk pattern (low ERI, low OVC), found in 24% of participants; a relatively low-risk pattern (low ERI, mo…

C1-02: Randomized Phase II study of vandetanib alone or in combination with carboplatin and paclitaxel as 1st-line treatment for advanced NSCLC

2007

Nintedanib in non-small cell lung cancer: from preclinical to approval

2015

Angiogenesis is a driving force of a tumor’s development. Targeting this process is an attractive option, as this is a feature shared by most of the solid tumors. A lot of antiangiogenic drugs have been developed following this path, including bevacizumab, sorafenib, sunitinib, vandetanib, ramucirumab, motesanib and many others. The latest drug of this class to be approved for patients with non-small cell lung cancer (NSCLC) was nintedanib, a triple angiokinase inhibitor. This molecule targets vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) and fibroblast growth factor (FGF) pathways, avoiding the tumor’s switch to normal escape mechanisms. The pharmacokine…

Dissociation energies of silver clusters Agn+, n=14, 15, 16, 18

2003

A recently developed method to determine dissociation energies has been applied to positively charged silver clusters of size n=14, 15, 16 and 18. The method uses a combination of sequential and single step decays. It requires an uncalibrated thermometer which here is provided by the evaporation rate constants of the product clusters. For this purpose, earlier measurements [J. Chem. Phys. 57 (1998) 2786] are reanalyzed with the new method. The resulting dissociation energies are compared with the liquid drop values and the measured decay rate constants with expected rate constants from detailed balance theory.

The Dark Side of Value Co-Creation: The Example of French Commercial Architecture

2018

Innovation is a network activity where different actors collaborate. An ethnographic survey of the French commercial architecture industry highlights the ambivalence of this co-production process. The results identify the sources of co-creation and co-destruction related both to the motivations of the actors and their interactions and examines their consequences. Retailers are encouraged to reposition themselves as project leaders, responsible for both assigning roles and mediating between the creative and technical functions. The development of new communication platforms to overcome interpretive biases between the diverse set of actors is also recommended.