Search results for "DHA"
showing 10 items of 65 documents
Evaluación preclínica de la toxicidad retiniana en la administración intravítrea de ácido docosahexaenoico en modelo experimental de conejo
2013
Objetivo: Evaluar la toxicidad retiniana a corto plazo de la administración intravítrea de una dosis única de ácido docosahexaenoico (DHA) en un modelo experimental de conejo. Material y métodos: Dieciséis conejos albinos Nueva Zelanda fueron seleccionados para este estudio toxicológico preclínico. Se prepararon seis concentraciones de DHA (Brudy Laboratorios, Barcelona, España): 10mg/50μl, 5mg/50μl, 2'5mg/50μl, 50μg/50μl, 25μg/50μl, 5μg/50μl. Cada concentración fue inyectada por vía pars plana en inyección intravítrea en el ojo derecho de dos conejos. La solución vehículo se inyectó en el ojo derecho de cuatro animales que se consideraron el grupo control. Se evaluó la seguridad retiniana …
Representing Tibetan Buddhism in books on spirituality : A discourse-historical approach
2022
This article looks into how Tibetan Buddhism is framed in terms of East-West dichotomy in six popular books on Buddhism and spirituality. Discourse Historical Approach is employed to uncover the rhetorical representation of Tibetan Buddhism to the readers. A critical post-colonial perspective offers an insight into various power dynamics, arising from these representations, structured according to Yoshikawa's model of intercultural communication between East and West. The various power outcomes of rhetorical styles range from Ethnocentric to Dialogical, with their ethical consequences and problematics discussed.
The rhetorical construction of Hillary Rodham Clinton as a presidential contender in 2016: A case study of hillaryclinton.com
2016
Niniejsze studium poświęcone jest retorycznym sposobom konstruowania obrazu kandydatki na prezydenta USA Hillary Rodham Clinton podczas pierwszej fazy kampanii 2016 roku. Kontekstem studium jest literatura na temat różnic genderowych w dyskursie politycznym, a w szczególności badania poświęcone medialnym reprezentacjom kobiet w polityce, z których wynika, że kobiety, przynajmniej w USA, muszą bardziej aktywnie niż mężczyźni kreować swój publiczny wizerunek. Za pomocą perspektywy retorycznej, zbadano strategiczny sposób konstruowania i kontrolowania publicznego obrazowania Hillary Clinton w reakcji na przedstawienia jej kandydatury przez media głównego nurtu. Analizie poddano materiały tekst…
Expression of the succinate dehydrogenase genes (sdhCAB) from the facultatively anaerobic paenibacillus macerans during aerobic growth
1998
Paenibacillus (formerly Bacillus) macerans is capable of succinate oxidation under oxic conditions and fumarate reduction under anoxic conditions. The reactions are catalyzed by different enzymes, succinate dehydrogenase (Sdh) and fumarate reductase (Frd). The genes encoding Sdh (sdhCAB) were analyzed. The gene products of sdhA and sdhB were similar to the subunits of known Sdh and Frd enzymes. The hydrophobic subunit SdhC showed close sequence similarity to the class of Sdh/Frd enzymes containing diheme cytochrome b. From the sdhCAB gene cluster two transcripts were produced, one comprising sdhCAB, the other sdhAB. The transcripts were found only during aerobic growth, and the amount was d…
Zircon evaporation ages and geochemistry of metamorphosed volcanic rocks from the Vinjamuru domain, Krishna Province: evidence for 1.78 Ga convergent…
2012
Palaeoproterozoic intermediate to potassic felsic volcanism in volcano-sedimentary sequences could either have occurred in continental rift or at convergent magmatic arc tectonic settings. The Vinjamuru domain of the Krishna Province in Andhra Pradesh, SE India, contains such felsic and intermediate metavolcanic rocks, whose geochemistry constrains their probable tectonic setting and which were dated by the zircon Pb evaporation method in order to constrain their time of formation. These rocks consist of interlayered quartz–garnet–biotite schist, quartz–hematite–baryte–sericite schist as well as cherty quartzite, and represent a calc-alkaline volcanic sequence of andesitic to rhyolitic rock…
Efficacy and safety study of an eyelid gel after repeated nocturnal application in healthy contact lens users and non-users
2020
Purpose: To evaluate skin biocompatibility of a nighttime hydrating eyelid gel and possible ocular surface effects in contact lens users (CLU) and non-contact lens users (NCLU). The formulation is registered as a medical device as Tridocosahexaenoine-AOX® (TDHA-AOX) (a concentrated DHA triglyceride), containing also hyaluronic acid (HA). Methods: A prospective, randomized, masked clinical trial was performed with 62 participants of both sexes, aged 20–70 years, split into: (1) CLU (n = 30) and (2) NCLU (n = 32). All participants were instructed to apply a single dose of the moisturizing gel (containing TDHA-AOX and HA) nightly to the upper and inner eyelids of their right eye (RE) only, and…
Chimpanzees surviving in a fragmented high‐altitude forest landscape of the Congolese Albertine Rift
2021
This paper documents a community of eastern chimpanzees (Pan troglodytes schweinfurthii Giglioli, 1872) inhabiting three relict forest fragments situated on the Lake Albert escarpment, down the Ituri highlands, of eastern Democratic Republic of the Congo (DRC). The area explored had a combined forested surface of ±18.15 km2 in 2017, shrinking by 1.2% per year between 2010 and 2015. Between 2015 and 2017, we found 160 chimpanzee nests along 37.6 km of pilot walks, some up to 2,000 m altitude. Another 123 nests logged along 6.7 km transects led to an estimate of chimpanzee density of 4.62 weaned individuals per square kilometer of forest habitat. Camera‐trap images and direct observations rev…
Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster
2016
Contains fulltext : 172720.pdf (Publisher’s version ) (Open Access) Recently, activating mutations of the hypoxia-inducible factor 2alpha gene (HIF2A/EPAS1) have been recognized to predispose to multiple paragangliomas (PGLs) and duodenal somatostatinomas associated with polycythemia, and ocular abnormalities. Previously, mutations in the SDHA/B/C/D, SDHAF2, VHL, FH, PHD1, and PHD2 genes have been associated with HIF activation and the development of pseudohypoxic (cluster-1) PGLs. These tumors overlap in terms of tumor location, syndromic presentation, and noradrenergic phenotype to a certain extent. However, they also differ especially by clinical outcome and by presence of other tumors o…
Objectively measured far vision impairment and sarcopenia among adults aged ≥ 65 years from six low- and middle-income countries
2021
Background:\ud \ud There are currently no studies on visual impairment and sarcopenia. We investigated the cross-sectional association between objectively measured far vision impairment and sarcopenia in a nationally representative sample of older adults aged 65 years and over from six low- and middle-income countries (LMICs).\ud \ud Methods:\ud \ud Cross-sectional, community-based data from the study on global ageing and adult health (SAGE) were analyzed. Far vision acuity was measured using the tumbling E LogMAR chart and classified as: no vision impairment (6/12 or better); mild vision impairment (6/18 or better but worse than 6/12); moderate vision impairment (6/60 or better but worse t…
DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2/HO-1 axis
2019
Docosahexaenoic acid (DHA) is an omega‑3 polyunsaturated fatty acid, derived mainly from fish oil. It is well known that DHA is present in high concentrations in nervous tissue and plays an important role in brain development and neuroprotection. However, the molecular mechanisms underlying its role remain to be fully elucidated. In this study, to enhance our understanding of the pathophysiological role of DHA, we investigated the possible neuroprotective mechanisms of action of DHA against hydrogen peroxide (H2O2)‑induced oxidative damage in a rat pheochromocytoma cell line (PC12). Specifically, we evaluated the viability, oxidation potential, and the expression and production of antioxida…