Search results for "DIAGNOSTICA"

showing 10 items of 607 documents

Novel and known genetic variants for male breast cancer risk at 8q24.21, 9p21.3, 11q13.3 and 14q24.1: Results from a multicenter study in Italy

2015

Increasing evidence indicates that common genetic variants may contribute to the heritable risk of breast cancer (BC). In this study, we investigated whether single nucleotide polymorphisms (SNPs), within the 8q24.21 multi-cancer susceptibility region and within BC-associated loci widespread in the genome, may influence the risk of BC in men, and whether they may be associated with specific clinical-pathologic characteristics of male BC (MBC). In the frame of the ongoing Italian Multicenter Study on MBC, we performed a case-control study on 386 MBC cases, including 50 BRCA1/2 mutation carriers, and 1105 healthy male controls, including 197 unaffected BRCA1/2 mutation carriers. All 1491 subj…

MaleCancer ResearchPredictive Value of Test8q24.21; BRCA1/2; Clinical-pathologic characteristics; Low-penetrance BC alleles; Male breast cancer; SNPs; BRCA1 Protein; BRCA2 Protein; Biomarkers Tumor; Breast Neoplasms Male; Case-Control Studies; Chi-Square Distribution; Gene Frequency; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Italy; Linear Models; Logistic Models; Male; Multivariate Analysis; Mutation; Odds Ratio; Phenotype; Predictive Value of Tests; Risk Factors; Chromosomes Human Pair 11; Chromosomes Human Pair 14; Chromosomes Human Pair 8; Chromosomes Human Pair 9; Polymorphism Single Nucleotide; Oncology; Cancer ResearchGene FrequencyRisk FactorsGenotypeOdds RatioMedicineskin and connective tissue diseasesMultivariate AnalysiSettore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIAGeneticsClinical-pathologic characteristicsBRCA1 ProteinClinical-pathologic characteristicHomozygoteLow-penetrance BC allelesPhenotype8q24.21OncologyItalyMale breast cancer8q24.21; BRCA1/2; Clinical-pathologic characteristics; Low-penetrance BC alleles; Male breast cancer; SNPs; Cancer Research; OncologyLinear ModelCase-Control StudieChromosomes Human Pair 9HumanChromosomes Human Pair 8SNPsHeterozygoteLogistic ModelSNPSingle-nucleotide polymorphismPolymorphism Single NucleotideBreast Neoplasms MaleBreast cancerPredictive Value of TestsBRCA1/2Biomarkers TumorSNPHumansGenetic Predisposition to DiseaseAllele frequencyBRCA2 ProteinChromosomes Human Pair 14Chi-Square Distributionbusiness.industryRisk FactorChromosomes Human Pair 11Case-control studyOdds ratiomedicine.diseaseMale breast cancerLogistic ModelsCase-Control StudiesMultivariate AnalysisMutationLinear ModelsbusinessLow-penetrance BC allele
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Quantification of epicardial adipose tissue in coronary calcium score and CT coronary angiography image data sets: comparison of attenuation values, …

2016

The aim of the study was to compare epicardial adipose tissue (EAT) characteristics assessed with coronary calcium score (CS) and CT coronary angiography (CTCA) image data sets.In 76 patients (mean age 59 ± 13 years) who underwent CS and CTCA owing to suspected coronary artery disease (CAD), EAT was quantified in terms of density (Hounsfield units), thickness and volume. The EAT volume was extracted with a semi-automatic software.A moderate correlation was found between EAT density in CS and CTCA image data sets (-100 ± 19 HU vs -70 ± 24 HU; p  0.05, r = 0.55). The distribution of EAT was not symmetrical with a maximal thickness at the right atrioventricular groove (14.2 ± 5.3 mm in CS, 15.…

MaleCoronary angiographyComputed Tomography AngiographyAdipose tissueCoronary Artery Disease030204 cardiovascular system & hematologyCoronary AngiographySensitivity and Specificity030218 nuclear medicine & medical imagingCoronary artery disease03 medical and health sciencesImaging Three-Dimensional0302 clinical medicineHounsfield scalemedicineHumansRadiology Nuclear Medicine and imagingVascular CalcificationAdiposityComputed tomography angiographyFull Papermedicine.diagnostic_testbusiness.industryReproducibility of ResultsMean ageGeneral MedicineMiddle Agedmedicine.diseaseCoronary Calcium ScoreAdipose Tissueepicardial adipose tissue CT coronary angiographyEpicardial adipose tissueRadiographic Image Interpretation Computer-AssistedFemaleSettore MED/36 - Diagnostica Per Immagini E RadioterapiabusinessNuclear medicinePericardiumAlgorithmsThe British Journal of Radiology
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Atherosclerotic pattern of coronary myocardial bridging assessed with CT coronary angiography

2012

The aim of our study was to evaluate the atherosclerotic pattern of patients with coronary myocardial bridging (MB) by means of CT Coronary Angiography (CT-CA). 254 consecutive patients (166 male, mean age 58.6 +/- A 10.3) who underwent 64-slice CT-CA according to current clinical indications were reviewed for the presence of MB and concomitant segmental atherosclerotic pattern. Coronary plaques were assessed in all patients enrolled. 73 patients (29%) presented single (90%) or multiple (10%) MB, frequently (93%) localized in the mid-distal left anterior descending artery. The MB segment was always free of atherosclerosis. Segments proximal to the MB presented: no atherosclerotic disease (n…

MaleCoronary angiographyMultislice computed tomographymedicine.medical_specialtyMyocardial bridgingCoronary angiographyCoronary artery diseaseCoronary artery diseasePredictive Value of TestsInternal medicineHumansMedicineRadiology Nuclear Medicine and imagingCardiac imagingAgedRetrospective StudiesChi-Square Distributionbusiness.industryCoronary StenosisReproducibility of ResultsMiddle Agedmedicine.diseaseTrunkPlaque Atheroscleroticmedicine.anatomical_structureItalyCoronary anomaliePredictive value of testsConcomitantCardiologyFemaleTomography X-Ray ComputedSettore MED/36 - Diagnostica Per Immagini E RadioterapiaCardiology and Cardiovascular MedicinebusinessChi-squared distributionArteryThe International Journal of Cardiovascular Imaging
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Collateral non cardiac findings in clinical routine CT coronary angiography: results from a multi-center registry.

2015

Purpose: The aim of the study was to evaluate the prevalence of collateral findings detected in computed tomography coronary angiography (CTCA) in a multi-center registry. Materials and methods: We performed a retrospective review of 4303 patients (2719 males, mean age 60.3 ± 10.2 years) undergoing 64-slice CTCA for suspected or known coronary artery disease (CAD) at various academic institutions between 01/2006 and 09/2010. Collateral findings were recorded and scored as: non-significant (no signs of relevant pathology, not necessary to be reported), significant (clear signs of pathology, mandatory to be reported), or major (remarkable pathology, mandatory to be reported and further invest…

MaleCoronary angiographymedicine.medical_specialtyComputed tomographyCoronary AngiographyCoronary artery diseaseComputed tomography coronary angiographyCollateral findingsCoronary artery diseaseComputed tomography coronary angiography Collateral findings Coronary artery disease Non-cardiac findingsmedicineHumansRadiology Nuclear Medicine and imagingRegistriesRetrospective StudiesNeuroradiologymedicine.diagnostic_testNon-cardiac findingsbusiness.industryUltrasoundInterventional radiologyGeneral MedicineMiddle AgedClinical routinemedicine.diseaseComputed tomography coronary angiography Collateral findings Coronary artery disease Non-cardiac findingsFemaleRadiologyTomography X-Ray ComputedSettore MED/36 - Diagnostica Per Immagini E RadioterapiabusinessFollow-Up Studies
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Ultrastructural biologic effects of sonography with pulse inversion and microbubble contrast in rabbit liver

2005

Purpose This prospective study was conducted to evaluate the biologic effects of microbubble destruction with pulse-inversion harmonic imaging on rabbit liver parenchyma. Methods The livers of 6 albino rabbits were examined sonographically by a single investigator. Three rabbits underwent contrast-enhanced sonography, with scanning starting 5 seconds after injection by using pulse-inversion harmonic imaging with a mechanical index of 1.2. Four time-triggered images were recorded at a rate of 1 frame every 2 seconds. For comparison, 3 control rabbits had pulse-inversion harmonic imaging with a mechanical index of 1.2 only, without contrast medium. Immediately after sonography, the animals we…

MaleCytoplasmPathologymedicine.medical_specialtyEndotheliumBiopsyultrasonography experimental studieContrast Mediaultrasonography biologic effectliverBone canaliculusMicroscopy Electron TransmissionAnimalsMedicineRadiology Nuclear Medicine and imagingProspective StudiesUltrasonographyMicrobubblesSettore BIO/16 - Anatomia Umanabusiness.industryUltrasoundAnatomyanimal studiesContrast mediummedicine.anatomical_structureHepatocyteultrasonography contrast mediaHepatocytesHepatic stellate cellUltrastructureRabbitsSettore MED/36 - Diagnostica Per Immagini E RadioterapiabusinessCell NucleolusMechanical indexJournal of Clinical Ultrasound
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Coronary CT angiography using iterative reconstruction 
vs. filtered back projection: evaluation of image quality.

2014

To compare image quality of iterative reconstruction algorithm(IRIS) vs. standard filtered back projection(FBP) reconstruction in CT Coronary Angiography (CTCA).Thirty-four consecutive patients underwent CTCA for suspected or known CAD with Dual-Source CT (DSCT-Flash, Siemens). All datasets were reconstructed with 0.75/0.4 and 0.6/0.4 mm slice thickness/increment, using three standard FBP kernels (B26-B30-B46) and three comparable IRIS algorithms (I26-I30-I46). Vascular attenuation and noise were measured. CT vascular attenuation values [HU] were measured in: ascending aorta (Ao), right (RCA) and left (LCA) coronary artery, respectively. Signal-to-noise (SNR) and contrast-to-noise (CNR) rat…

MaleImage Processing Computer-AssistedHumansFemaleCoronary Artery DiseaseProspective StudiesMiddle Agediterative reconstruction signal noise cardiac CT filtered back projectionSettore MED/36 - Diagnostica Per Immagini E RadioterapiaCoronary AngiographyTomography X-Ray ComputedAlgorithmsAged
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Preliminary experience with a transcranial magnetic resonance-guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series o…

2018

OBJECTIVETranscranial magnetic resonance–guided focused ultrasound surgery (tcMRgFUS) is one of the emerging noninvasive technologies for the treatment of neurological disorders such as essential tremor (ET), idiopathic asymmetrical tremor-dominant Parkinson’s disease (PD), and neuropathic pain. In this clinical series the authors present the preliminary results achieved with the world’s first tcMRgFUS system integrated with a 1.5-T MRI unit.METHODSThe authors describe the results of tcMRgFUS in a sample of patients with ET and with PD who underwent the procedure during the period from January 2015 to September 2017. A monolateral ventralis intermedius nucleus (VIM) thalamic ablation was pe…

MaleParkinson's diseaseMovement disordershigh-intensity focused ultrasound ablationIntraoperative Neurophysiological Monitoringmedicine.medical_treatmentinterventional030218 nuclear medicine & medical imagingMagnetic resonance guided focused ultrasound surgery0302 clinical medicineThalamusEssential tremorSettore MED/27 - NeurochirurgiaUltrasoundSettore MED/37 - NeuroradiologiaParkinson DiseaseGeneral MedicineMiddle AgedAblationMagnetic Resonance ImagingTreatment OutcomeNeuropathic painBBB = blood-brain barrier; ET = essential tremor; FRFSE = fast recalled FSE; FSE = fast spin echo; FSPGR = fast spoiled gradient echo; FTM = Fahn-Tolosa-Marin; HI-FU = high-intensity focused ultrasound; MRI; MRgFUS; MS = multiple sclerosis; PD = Parkinson’s disease; Parkinson’s disease; QUEST = Quality of Life in Essential Tremor; SWAN = susceptibility-weighted angiography; UPDRS = Unified Parkinson’s Disease Rating Scale; VIM = ventralis intermedius nucleus; brain; essential tremor; high-intensity focused ultrasound ablation; interventional; magnetic resonance–guided focused ultrasound surgery; stereotactic technique; tcMRgFUS = transcranial magnetic resonance–guided focused ultrasound surgerySettore MED/26 - NeurologiaFemaleRadiologymedicine.symptombrain; essential tremor; high-intensity focused ultrasound ablation; interventional; magnetic resonance-guided focused ultrasound surgery; mrgfus; mri; parkinson's disease; stereotactic techniqueMRIAdultmedicine.medical_specialtybrainEssential Tremormagnetic resonance–guided focused ultrasound surgery03 medical and health sciencesmedicineHumansmagnetic resonance-guided focused ultrasound surgeryUltrasonography InterventionalAgedThalamotomybusiness.industryMRgFUSmedicine.diseasestereotactic techniqueparkinson's diseaseParkinson’s diseaseSurgeryNeurology (clinical)businessSettore MED/36 - Diagnostica Per Immagini E Radioterapia030217 neurology & neurosurgeryFollow-Up StudiesNeurosurgical focus
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Isolated, subtle, neurological abnormalities in neurologically and cognitively healthy aging subjects

2015

The aim of this study is to describe the frequency of isolated, subtle, neurological abnormalities (ISNAs) in a large population of neurologically and cognitively healthy subjects and to compare ISNAs to various types of MRI-detected cerebrovascular lesions and subcortical brain atrophy in different age classes. 907 subjects were selected from a large, prospective hospital-based study. At baseline neurological examination, 17 ISNAs were selected. Primitive reflexes were the most common ISNAs (35.8 %), while dysphagia was the most rarely encountered (0.3 %). Measures of small vessel disease, i.e., deep and subcortical white matter hyperintensity and lacunar infarcts as well as subcortical at…

MalePrimitive reflexesAgingmedicine.medical_specialtyPathologyNeurologyNeurological examinationNeuropsychological TestsCarotid Intima-Media ThicknessAge DistributionApolipoproteins EAtrophyInternal medicinemedicineHumansAgedUltrasonographyNeuroradiologyAged 80 and overNeurologic ExaminationISNAs White matter hyperintensity Lacunae Subcortical atrophymedicine.diagnostic_testMyocardiumSettore MED/37 - NeuroradiologiaMagnetic resonance imagingMiddle Agedmedicine.diseaseMagnetic Resonance ImagingDysphagiaHyperintensityLogistic ModelsNeurologyCardiologyFemaleSettore MED/26 - NeurologiaNeurology (clinical)Nervous System Diseasesmedicine.symptomCognition DisordersSettore MED/36 - Diagnostica Per Immagini E RadioterapiaPsychologyJournal of Neurology
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Pediatric sialolithiasis distinctive characteristic in radiological imaging.

2011

Aim of the present paper was to investigate the imaging and related clinical characteristics of sialolithiasis in Italian pediatric population trying to determine the difference between pediatric and adult. Twenty-nine pediatric patients (age range 1-17 years) with pain and postprandial swelling and/or purulent discharge in the salivary gland areas were referred to radiology department after pediatric ear, nose and throat (ENT) evaluation. They all were submitted to ultrasound examination of the main salivary glands. Multidetector computed tomography (MDCT) only was performed in 2/6 patients, in 2/6 patients both sialography and MDCT were performed due to inconclusive MDCT features, 2/6 onl…

MaleSalivary Gland CalculiSialographySettore MED/20 - Chirurgia Pediatrica E InfantileSubmandibular GlandAge FactorsInfantYoung AdultHumansParotid GlandSalivary DuctsFemaleSettore MED/36 - Diagnostica Per Immagini E RadioterapiaChildPediatrics- lithiasis-sialographyUltrasonographyMinerva stomatologica
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Sialodochoplasty in the treatment of salivary-duct stricture in chronic sialoadenitis: technique and results

2007

PURPOSE: This study was undertaken to investigate peroral balloon angioplasty of salivary-duct strictures (sialodochoplasty) in chronic sialadenitis, analysing the technique, results and limitations. MATERIALS AND METHODS: Nine patients underwent sialodochoplasty: seven for Stensen''s-duct strictures and two for Wharton''s-duct strictures. One patient had a double stricture of Stensen''s duct and another a salivary stone associated with a Wharton''s-duct stricture. All patients were subjected to preliminary sialography to evaluate stricture site, length and grade. Sialodochoplasty was performed after local anaesthesia and progressive dilation of the salivary-duct orifice. RESULTS: The stric…

MaleSialodochoplastymedicine.medical_specialtySialographymedicine.medical_treatmentSettore MED/50 - Scienze Tecniche Mediche ApplicateSalivary duct strictureSalivary Gland DiseasesSIALODOCOPLASTY SIALOADENITISConstriction PathologicBalloonSialadenitisCatheterizationRecurrenceAngioplastyChronic sialoadenitisHumansSalivary DuctsMedicineRadiology Nuclear Medicine and imagingmedicine.diagnostic_testbusiness.industryInterventional radiologyGeneral MedicineMiddle Agedmedicine.diseaseFibrosisSialadenitisSurgeryTreatment OutcomeSettore MED/31 - OtorinolaringoiatriaFluoroscopyChronic DiseaseSalivary Duct CalculiFemaleSialographyRadiologySettore MED/36 - Diagnostica Per Immagini E RadioterapiabusinessFollow-Up StudiesLa radiologia medica
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